公开(公告)号：US20170044103A1

公开(公告)日：2017-02-16

申请号：US15129785

申请日：2015-03-26

申请人： Guangdi WANG ,  Shilong Zheng ,  Qui Zhong ,  Qiang Zheng

发明人： Guangdi WANG ,  Shilong Zheng ,  Qui Zhong ,  Qiang Zheng

IPC分类号： C07D213/61 ,  A61K31/4425 ,  A61K31/4418 ,  A61K45/06 ,  C07D213/30

CPC分类号： C07D213/61 ,  A61K31/4418 ,  A61K31/4425 ,  A61K45/06 ,  C07D213/30

摘要： Combretastatins analog compounds and their pharmaceutically acceptable salts are presented, as well as pharmaceutical compositions comprising the combretastatin analog compounds and uses of the combretastatin analog compounds, either alone or in combination with at least one additional therapeutic agent, in the treatment of cancer, and in particular cancer presenting as metastatic tumors.

摘要翻译： 本发明提供了组合复方和其药学上可接受的盐，以及包含考布他汀类似物化合物的药物组合物，以及考丁胺汀类似物化合物的单独使用或与至少一种另外的治疗剂组合用于治疗癌症，以及 特定的癌症呈现为转移性肿瘤。

公开(公告)号：US08653258B2

公开(公告)日：2014-02-18

申请号：US12597825

申请日：2008-06-06

申请人： Binghe Wang ,  Nanting Ni ,  Junfeng Wang ,  Chung-Dar Lu ,  Han-Ting Chou ,  Minyong Li ,  Shilong Zheng ,  Yunfeng Cheng ,  Hanjing Peng

发明人： Binghe Wang ,  Nanting Ni ,  Junfeng Wang ,  Chung-Dar Lu ,  Han-Ting Chou ,  Minyong Li ,  Shilong Zheng ,  Yunfeng Cheng ,  Hanjing Peng

IPC分类号： C07F5/02 ,  C12Q1/02

CPC分类号： C07D333/34 ,  C07F5/025

摘要： The present disclosure encompasses compounds and compositions that are useful as specific AI-2 antagonists for the control of bacterial quorum sensing. Although the AI-2 antagonists according to the present disclosure may not have bactericidal effect, their ability to attenuate virulence, drug resistance, and/or biofilm formation have therapeutic benefits. In addition, the AI-2 antagonists of the present disclosure can also be used as tools to probe bacterial AI-2 functions. The present disclosure also encompasses methods for inhibiting or attenuating microbial virulence, biofilm formation, and drug resistance. The methods are suitable for preventing bacteria from accruing and forming extensive biofilms that may be a health or hygiene hazard or a physical issue, such as in the blockage of water or fuel lines.

摘要翻译： 本公开涵盖可用作用于控制细菌群体感测的特异性AI-2拮抗剂的化合物和组合物。 虽然根据本公开的AI-2拮抗剂可能不具有杀菌作用，但是它们减轻毒力，耐药性和/或生物膜形成的能力具有治疗益处。 此外，本公开的AI-2拮抗剂也可以用作探针细菌AI-2功能的工具。 本公开还包括抑制或减弱微生物毒力，生物膜形成和耐药性的方法。 该方法适用于防止细菌累积和形成广泛的生物膜，这些生物膜可能是健康或卫生危害或物理问题，例如堵塞水或燃料管线。

公开(公告)号：US20100137249A1

公开(公告)日：2010-06-03

申请号：US12597825

申请日：2008-06-06

申请人： Binghe Wang ,  Nanting Ni ,  Junfeng Wang ,  Chung-Dar Lu ,  Han-Ting Chou ,  Minyong Li ,  Shilong Zheng ,  Yunfeng Cheng ,  Hanjing Peng

发明人： Binghe Wang ,  Nanting Ni ,  Junfeng Wang ,  Chung-Dar Lu ,  Han-Ting Chou ,  Minyong Li ,  Shilong Zheng ,  Yunfeng Cheng ,  Hanjing Peng

IPC分类号： A01N55/08 ,  C07F5/02 ,  C12Q1/02

CPC分类号： C07D333/34 ,  C07F5/025

摘要： The present disclosure encompasses compounds and compositions that are useful as specific AI-2 antagonists for the control of bacterial quorum sensing. Although the AI-2 antagonists according to the present disclosure may not have bactericidal effect, their ability to attenuate virulence, drug resistance, and/or biofilm formation have therapeutic benefits. In addition, the AI-2 antagonists of the present disclosure can also be used as tools to probe bacterial AI-2 functions. The present disclosure also encompasses methods for inhibiting or attenuating microbial virulence, biofilm formation, and drug resistance. The methods are suitable for preventing bacteria from accruing and forming extensive biofilms that may be a health or hygiene hazard or a physical issue, such as in the blockage of water or fuel lines.

摘要翻译： 本公开涵盖可用作用于控制细菌群体感测的特异性AI-2拮抗剂的化合物和组合物。 虽然根据本公开的AI-2拮抗剂可能不具有杀菌作用，但是它们减轻毒力，耐药性和/或生物膜形成的能力具有治疗益处。 此外，本公开的AI-2拮抗剂也可以用作探针细菌AI-2功能的工具。 本公开还包括抑制或减弱微生物毒力，生物膜形成和耐药性的方法。 该方法适用于防止细菌累积和形成广泛的生物膜，这些生物膜可能是健康或卫生危害或物理问题，例如堵塞水或燃料管线。