公开(公告)号：US11918549B2

公开(公告)日：2024-03-05

申请号：US16641749

申请日：2018-08-27

申请人： AZ SOLUTIONS LLC

发明人： Derek Hill

IPC分类号： A61K31/155 ,  A61K31/4425 ,  A61K33/30 ,  A61K33/34 ,  A61K33/38 ,  A61K45/06 ,  A61M1/00 ,  A61M3/02

CPC分类号： A61K31/155 ,  A61K31/4425 ,  A61K33/30 ,  A61K33/34 ,  A61K33/38 ,  A61M3/0241 ,  A61M3/0258 ,  A61M3/0262 ,  A61K45/06 ,  A61M1/77 ,  A61M3/0245

摘要： A wound irrigation system includes a first fluid including an ion rich compound having free available ions; and a second fluid including an oxidation-reduction potential increasing compound, the second fluid housed separately from the first fluid. Mixing the first and second fluids in a charging area forms an ionically charged fluid with an oxidation-reduction potential higher than a wound site oxidation-potential. The ionically charged fluid increases antimicrobial activity of the wound upon application.

公开(公告)号：US20240041852A1

公开(公告)日：2024-02-08

申请号：US18487241

申请日：2023-10-16

申请人： ARMS Pharmaceutical LLC

发明人： Afif Ghannoum ,  Brian Vincent Sokol

IPC分类号： A61K31/4425 ,  A61K45/06 ,  A61K9/00 ,  A61K31/155 ,  A61K47/10 ,  A61K47/36

CPC分类号： A61K31/4425 ,  A61K45/06 ,  A61K9/006 ,  A61K31/155 ,  A61K47/10 ,  A61K47/36 ,  Y02A50/30

摘要： A method for treating a disease or for treating a symptom of a disease, or a combination of both, the disease being caused or aggravated by microorganisms includes: treating the disease, treating the symptom of the disease, or reducing the duration of the disease, or a combination of both by administering a barrier-forming composition in a therapeutically effective amount to a surface, the surface comprising a mammal mucosa, the mammal being infected with the disease or experiencing symptoms of the disease caused or aggravated by the microorganisms. The barrier-forming composition includes an antimicrobial. Upon administering the composition, the method includes forming a barrier coating on the surface that is active to kill or neutralize microorganisms encountered by the barrier coating. A composition with an agent active for relieving symptoms of a disease is also included.

公开(公告)号：US11690833B2

公开(公告)日：2023-07-04

申请号：US16955160

申请日：2018-12-07

申请人： Colgate-Palmolive Company

发明人： Viktor Dubovoy ,  Junhong Mao ,  Ravi Subramanyam ,  Long Pan ,  Tatiana Brinzari

IPC分类号： A61K31/4425 ,  A61K47/52

CPC分类号： A61K31/4425 ,  A61K47/52

摘要： Described herein are complexes comprising a cationic antibacterial agent and a metal salt, personal care compositions comprising same; along with methods of making and using these complexes and compositions.

公开(公告)号：US11684555B2

公开(公告)日：2023-06-27

申请号：US16884851

申请日：2020-05-27

申请人： The Research Foundation for the State University of New York

发明人： Marvin Cohen ,  Susanne Cohen ,  Robert Flynn

IPC分类号： A61K8/27 ,  A61K8/20 ,  A61K8/92 ,  A61Q11/00 ,  A61K45/06 ,  A61K9/00 ,  A61K33/20 ,  A61K33/30 ,  A61K8/19 ,  A61K8/34 ,  A61K47/02 ,  A61K47/10 ,  A61K8/22 ,  A61K8/368 ,  A61K9/08 ,  A61K31/4425 ,  A61K33/40 ,  A61K8/49 ,  A61K31/435 ,  A61K8/36

CPC分类号： A61K8/27 ,  A61K8/19 ,  A61K8/20 ,  A61K8/22 ,  A61K8/345 ,  A61K8/36 ,  A61K8/368 ,  A61K8/4926 ,  A61K8/922 ,  A61K9/0063 ,  A61K9/08 ,  A61K31/435 ,  A61K31/4425 ,  A61K33/20 ,  A61K33/30 ,  A61K33/40 ,  A61K45/06 ,  A61Q11/00 ,  A61K47/02 ,  A61K47/10 ,  A61K2800/882 ,  A61K2800/92 ,  A61K31/4425 ,  A61K2300/00 ,  A61K33/40 ,  A61K2300/00 ,  A61K33/20 ,  A61K2300/00 ,  A61K33/30 ,  A61K2300/00 ,  A61K33/40 ,  A61L2300/00

摘要： Oral compositions and methods of use thereof are provided herein. The oral compositions comprise a first component comprising at least one Eh-raising compound and a pharmaceutically acceptable carrier, and a second component comprising at least one zinc compound, an anti-microbial agent and a pharmaceutically acceptable carrier.

公开(公告)号：US20230191047A1

公开(公告)日：2023-06-22

申请号：US18082311

申请日：2022-12-15

申请人： Belhaven BioPharma Inc.

发明人： Scott Lyman ,  Barry Bleske

IPC分类号： A61M15/08 ,  A61K9/00 ,  A61K9/16 ,  A61K31/55 ,  A61K31/137 ,  A61K31/5513 ,  A61K31/46 ,  A61K31/4425 ,  A61K31/417 ,  A61K31/277 ,  A61K31/13

CPC分类号： A61M15/08 ,  A61K9/0043 ,  A61K9/1652 ,  A61K9/1623 ,  A61K9/1611 ,  A61K31/55 ,  A61K31/137 ,  A61K31/5513 ,  A61K31/46 ,  A61K31/4425 ,  A61K31/417 ,  A61K31/277 ,  A61K31/13 ,  A61M2209/06 ,  A61M2205/3327

摘要： Provided herein are dry powder formulations comprising at least one active pharmaceutical ingredient suitable for nasal application. Also provided are unit dose forms and devices comprising such formulations and methods of using such formulations for the treatment of various conditions including respiratory conditions, hemodynamic collapse, seizures, migraines, and other conditions.

公开(公告)号：US20180161334A1

公开(公告)日：2018-06-14

申请号：US15565317

申请日：2016-04-08

申请人： VAIOMER

发明人： Bérengère COUPÉ ,  Michael COURTNEY

IPC分类号： A61K31/5377 ,  A61K31/4425 ,  A61K31/7024 ,  A61K45/06 ,  A61P3/10

CPC分类号： A61K31/5377 ,  A61K31/4425 ,  A61K31/7024 ,  A61K45/06 ,  A61P3/10 ,  A61K2300/00

摘要： The present invention concerns a factor Xa inhibitor for use as a medicament in a method for regulating glycemia in a subject, in particular for use for preventing and/or treating hyperglycemia, impaired glucose tolerance, impaired fasting glucose, insulin resistance and/or diabetes.

公开(公告)号：US09993464B2

公开(公告)日：2018-06-12

申请号：US15265191

申请日：2016-09-14

申请人： SANOFI

发明人： Walter Kamm ,  Till Bussemer ,  Doris Andert ,  Bernd Kuehn ,  Ernst-Josef Todt

IPC分类号： A61K31/4425 ,  A61K47/12 ,  A61K9/00

CPC分类号： A61K31/4425 ,  A61K9/0019 ,  A61K31/4409 ,  A61K47/12

摘要： The invention relates to a pharmaceutical composition comprising methyl (2R.3R)-2-{3-[amino(imino)methyl]benzyl}-3-{[4-(1-oxidopyridin-4-yl)benzoyl]amino}butanoate or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable acidic reacting compound or to an aqueous solution or dispersion of the composition as well as a process for the preparation of the same, methods of using such compositions to treat subjects suffering from conditions which can be ameliorated by the administration of an inhibitor of Factor Xa.

公开(公告)号：US20180153177A1

公开(公告)日：2018-06-07

申请号：US15886791

申请日：2018-02-01

申请人： The Trustees of Columbia University in the City of New York

发明人： Shanta M. Modak ,  Arnab Kumar Ghosh ,  Lauserpina Caraos

IPC分类号： A01N65/44 ,  A61K36/28 ,  A01N65/00 ,  A61K8/365 ,  A61K8/41 ,  A61K31/05 ,  A61K36/185 ,  A61K8/60 ,  C02F3/32 ,  A61K9/06 ,  A01N65/06 ,  A61K36/15 ,  A01N65/36 ,  A61K31/14 ,  A61K31/085 ,  A01N47/44 ,  A61K31/4425 ,  A61Q17/00 ,  A01N25/16 ,  A61K9/00 ,  A61K36/899

CPC分类号： A01N65/44 ,  A01N25/16 ,  A01N31/02 ,  A01N31/08 ,  A01N31/12 ,  A01N31/14 ,  A01N33/12 ,  A01N47/44 ,  A01N65/00 ,  A01N65/06 ,  A01N65/22 ,  A01N65/36 ,  A61K8/34 ,  A61K8/345 ,  A61K8/347 ,  A61K8/365 ,  A61K8/368 ,  A61K8/416 ,  A61K8/43 ,  A61K8/60 ,  A61K8/97 ,  A61K9/0014 ,  A61K9/0017 ,  A61K9/06 ,  A61K31/047 ,  A61K31/05 ,  A61K31/085 ,  A61K31/14 ,  A61K31/155 ,  A61K31/4425 ,  A61K31/60 ,  A61K36/15 ,  A61K36/185 ,  A61K36/28 ,  A61K36/53 ,  A61K36/752 ,  A61K36/80 ,  A61K36/886 ,  A61K36/898 ,  A61K36/899 ,  A61K36/9066 ,  A61K2800/30 ,  A61K2800/592 ,  A61Q11/00 ,  A61Q17/005 ,  A61Q19/10 ,  C02F3/327 ,  C02F2103/005 ,  C02F2303/04 ,  C11D3/48 ,  A61K2300/00 ,  A01N37/36

摘要： Disclosed herein are antimicrobial compositions comprising mixtures of botanical extracts, synthetic antimicrobial agents and essential oils which do not rely solely upon alcohol to produce their antimicrobial effects.

公开(公告)号：US20180055831A1

公开(公告)日：2018-03-01

申请号：US15685119

申请日：2017-08-24

申请人： Theravance Biopharma R&D IP, LLC

发明人： Sharathchandra S. Hegde

IPC分类号： A61K31/4465 ,  C07D211/22

CPC分类号： A61K31/4465 ,  A61K31/165 ,  A61K31/198 ,  A61K31/4425 ,  A61K31/573 ,  A61K45/06 ,  C07D211/22 ,  A61K2300/00

摘要： The invention relates to methods for treating neurogenic orthostatic hypotension and symptoms thereof using 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine or a pharmaceutically-acceptable salt thereof.

公开(公告)号：US09850265B2

公开(公告)日：2017-12-26

申请号：US14403167

申请日：2012-05-25

申请人： Georg Schlechtingen ,  Hans-Joachim Knölker ,  Tim Friedrichson ,  Gary Jennings ,  Tobias Braxmeier

发明人： Georg Schlechtingen ,  Hans-Joachim Knölker ,  Tim Friedrichson ,  Gary Jennings ,  Tobias Braxmeier

IPC分类号： C07F9/40 ,  C07D211/62 ,  C07D211/46 ,  C07D295/037 ,  C07C229/12 ,  A61K31/205 ,  C07F9/38 ,  C07C309/14 ,  A61K31/662 ,  A61K31/4425

CPC分类号： C07F9/4006 ,  A61K31/205 ,  A61K31/4425 ,  A61K31/662 ,  C07C229/12 ,  C07C309/14 ,  C07D211/06 ,  C07D211/46 ,  C07D211/60 ,  C07D211/62 ,  C07D295/037 ,  C07F9/3808

摘要： The present invention relates to amino- or ammonium-containing sulfonic acid, phosphonic acid and carboxylic acid derivatives, in particular the compounds of formula 1, 2, 3, 4, 5 or 6, and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder.