公开(公告)号：US12152029B2

公开(公告)日：2024-11-26

申请号：US18051654

申请日：2022-11-01

Applicant: H. Lundbeck A/S

Inventor： Thomas Vetter ,  Martin Juhl ,  Heidi Lopez De Diego ,  Cheryl A. Grice ,  John J. M. Wiener ,  Daniel J. Buzard ,  Amy Allan ,  Susana Del Rio Gancedo ,  Samuel George Andrew ,  Antonio Cincotti ,  Adam Ross Patterson ,  Richard James Edwards

IPC: C07D471/10

Abstract: Described herein are new crystalline forms of the MAGL inhibitor 1-(1-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)-1,8-diazaspiro[4.5]decane-8-carbonyl)-1H-pyrazole-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11434222B2

公开(公告)日：2022-09-06

申请号：US17524632

申请日：2021-11-11

Applicant: H. LUNDBECK A/S

Inventor： John J. M. Wiener ,  Cheryl A. Grice ,  Daniel J. Buzard ,  Justin S. Cisar ,  Olivia Delene Weber ,  Amy Allan ,  Nicholas Raffaele ,  Jeanne Moody ,  Michael B. Shaghafi

IPC: C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07F9/6558 ,  C07D401/14 ,  A61P25/04 ,  C07D487/04 ,  C07D471/04 ,  C07D417/12 ,  A61P25/08 ,  C07D221/20

Abstract: Provided herein are substituted 1,1,1,3,3,3-hexafluoropropan-2-yl 6-azaspiro[2.5]octane-6-carboxylate compounds and pharmaceutical compositions comprising said compounds. The compounds and compositions provided herein are useful as inhibitors of MAGL. Furthermore, the compounds and compositions as provided herein are useful for the treatment of diseases and disorders benefiting from the inhibition of MAGL.

公开(公告)号：US11655217B2

公开(公告)日：2023-05-23

申请号：US16615747

申请日：2018-05-22

Applicant: H. Lundbeck A/S

Inventor： Cheryl A. Grice ,  John J. M. Wiener ,  Olivia D. Weber ,  Katharine K. Duncan

IPC: A61K31/496 ,  A61P25/06 ,  A61K31/5377 ,  C07D231/14 ,  A61P29/00 ,  C07D401/14 ,  C07D405/10 ,  C07D471/04 ,  C07D491/08 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D451/02 ,  C07D471/10 ,  C07D487/04 ,  C07D491/048 ,  C07D519/00

CPC classification number: C07D231/14 ,  A61K31/496 ,  A61K31/5377 ,  A61P25/06 ,  A61P29/00 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D451/02 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D491/048 ,  C07D491/08 ,  C07D519/00

Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising the same. The compounds and compositions are useful as modulators of monoacylglycerol lipase (MAGL). Furthermore, the compounds and compositions are useful for the treatment of pain.

公开(公告)号：US12258340B2

公开(公告)日：2025-03-25

申请号：US18185227

申请日：2023-03-16

Applicant: H. Lundbeck A/S

Inventor： Cheryl A. Grice ,  John J. M. Wiener ,  Olivia D. Weber ,  Katharine K. Duncan

IPC: A61K31/499 ,  A61K31/496 ,  A61K31/5377 ,  A61P25/06 ,  A61P29/00 ,  C07D231/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D451/02 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D491/048 ,  C07D491/08 ,  C07D519/00

Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising the same. The compounds and compositions are useful as modulators of monoacylglycerol lipase (MAGL). Furthermore, the compounds and compositions are useful for the treatment of pain.

公开(公告)号：US11149037B2

公开(公告)日：2021-10-19

申请号：US16615746

申请日：2018-05-22

Applicant: H. Lundbeck A/S

Inventor： Cheryl A. Grice ,  Olivia D. Weber ,  Daniel J. Buzard ,  Michael B. Shaghafi ,  John J. M. Wiener ,  Justin S. Cisar ,  Katharine K. Duncan

IPC: A61K31/4155 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/496 ,  A61P25/00 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D491/048 ,  C07D491/08 ,  C07D519/00 ,  C07D498/08

Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.