公开(公告)号：US12152029B2

公开(公告)日：2024-11-26

申请号：US18051654

申请日：2022-11-01

Applicant: H. Lundbeck A/S

Inventor： Thomas Vetter ,  Martin Juhl ,  Heidi Lopez De Diego ,  Cheryl A. Grice ,  John J. M. Wiener ,  Daniel J. Buzard ,  Amy Allan ,  Susana Del Rio Gancedo ,  Samuel George Andrew ,  Antonio Cincotti ,  Adam Ross Patterson ,  Richard James Edwards

IPC: C07D471/10

Abstract: Described herein are new crystalline forms of the MAGL inhibitor 1-(1-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)-1,8-diazaspiro[4.5]decane-8-carbonyl)-1H-pyrazole-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11691975B2

公开(公告)日：2023-07-04

申请号：US17343227

申请日：2021-06-09

Applicant: H. Lundbeck A/S

Inventor： Cheryl A. Grice ,  Daniel J. Buzard ,  Michael B. Shaghafi

IPC: A61K31/438 ,  A61K31/407 ,  C07D471/10

CPC classification number: C07D471/10

Abstract: Provided herein are spirocyclic and fused bicyclic carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US11149037B2

公开(公告)日：2021-10-19

申请号：US16615746

申请日：2018-05-22

Applicant: H. Lundbeck A/S

Inventor： Cheryl A. Grice ,  Olivia D. Weber ,  Daniel J. Buzard ,  Michael B. Shaghafi ,  John J. M. Wiener ,  Justin S. Cisar ,  Katharine K. Duncan

IPC: A61K31/4155 ,  A61K31/438 ,  A61K31/4439 ,  A61K31/496 ,  A61P25/00 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D487/10 ,  C07D491/048 ,  C07D491/08 ,  C07D519/00 ,  C07D498/08

Abstract: Provided herein are pyrazole compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US11059822B2

公开(公告)日：2021-07-13

申请号：US16349047

申请日：2017-11-15

Applicant: H. LUNDBECK A/S

Inventor： Cheryl A. Grice ,  Daniel J. Buzard ,  Michael B. Shaghafi

IPC: C07D471/10 ,  A61K31/438

Abstract: Provided herein are spirocyclic and fused bicyclic carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US11332453B2

公开(公告)日：2022-05-17

申请号：US17055079

申请日：2019-05-14

Applicant: H. Lundbeck A/S

Inventor： Cheryl A. Grice ,  Daniel J. Buzard ,  Michael B. Shaghafi

IPC: C07D295/185 ,  C07D305/06 ,  C07D263/32 ,  C07D241/12 ,  C07D213/55 ,  C07D305/08

Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US11161856B2

公开(公告)日：2021-11-02

申请号：US16642713

申请日：2018-08-28

Applicant: H. Lundbeck A/S

Inventor： Cheryl A. Grice ,  Olivia D. Weber ,  Daniel J. Buzard ,  Michael B. Shaghafi

IPC: C07D519/00 ,  C07D401/12 ,  C07D211/58 ,  C07D471/10

Abstract: Provided herein are compounds of the formula: and compositions comprising the same, which are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US11434222B2

公开(公告)日：2022-09-06

申请号：US17524632

申请日：2021-11-11

Applicant: H. LUNDBECK A/S

Inventor： John J. M. Wiener ,  Cheryl A. Grice ,  Daniel J. Buzard ,  Justin S. Cisar ,  Olivia Delene Weber ,  Amy Allan ,  Nicholas Raffaele ,  Jeanne Moody ,  Michael B. Shaghafi

IPC: C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07F9/6558 ,  C07D401/14 ,  A61P25/04 ,  C07D487/04 ,  C07D471/04 ,  C07D417/12 ,  A61P25/08 ,  C07D221/20

Abstract: Provided herein are substituted 1,1,1,3,3,3-hexafluoropropan-2-yl 6-azaspiro[2.5]octane-6-carboxylate compounds and pharmaceutical compositions comprising said compounds. The compounds and compositions provided herein are useful as inhibitors of MAGL. Furthermore, the compounds and compositions as provided herein are useful for the treatment of diseases and disorders benefiting from the inhibition of MAGL.

公开(公告)号：US11214557B2

公开(公告)日：2022-01-04

申请号：US16739642

申请日：2020-01-10

Applicant: H. Lundbeck A/S

Inventor： Cheryl A. Grice ,  Daniel J. Buzard ,  Michael B. Shaghafi

IPC: C07D295/185 ,  C07D305/08 ,  C07D213/55 ,  C07D241/12 ,  C07D263/32 ,  C07D305/06

Abstract: Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.

公开(公告)号：US11142526B2

公开(公告)日：2021-10-12

申请号：US16642717

申请日：2018-08-28

Applicant: H. Lundbeck A/S

Inventor： Cheryl A. Grice ,  Olivia D. Weber ,  Daniel J. Buzard ,  Michael B. Shaghafi ,  Todd K. Jones

IPC: C07D471/10 ,  C07D401/12 ,  C07D409/12 ,  C07D487/04 ,  C07D519/00 ,  A61P25/02 ,  A61P1/00 ,  A61P25/08 ,  A61P25/06

Abstract: Provided herein are compounds and compositions useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.