公开(公告)号：US3687977A

公开(公告)日：1972-08-29

申请号：US3687977D

申请日：1969-09-05

Applicant: HOECHST AG

Inventor： RIPPEL ROBERT ,  DITTMAR WALTER ,  SCHORR MANFRED

IPC: C07D333/36 ,  C07D333/38 ,  A61K27/00 ,  C07D63/16

CPC classification number: C07D333/36 ,  C07D333/38

Abstract: Thiophene-3-isonitriles of the formula IN WHICH R1 is hydrogen, alkyl, carbalkoxy, cyano or phenyl, R2 is hydrogen, alkyl, alkoxy, carbalkoxy, cyano or phenyl, R3 is hydrogen, alkyl, carbalkoxy or phenyl, or R2 and R3 together represent an alkylene chain, are disclosed as having antimycotic and antibacterial properties.

Abstract translation: 噻吩-3-异腈，其中R1是氢，烷基，烷氧基，氰基或苯基，R2是氢，烷基，烷氧基，烷氧基，氰基或苯基，R3是氢，烷基，烷氧基或苯基，或R2和R3 一起表示亚烷基链，被公开为具有抗真菌性和抗菌性。

公开(公告)号：US3883545A

公开(公告)日：1975-05-13

申请号：US31738772

申请日：1972-12-22

Applicant: HOECHST AG

Inventor： LOHAUS GERHARD ,  DITTMAR WALTER

IPC: C07D213/89 ,  C07D31/30

CPC classification number: C07D213/89

Abstract: New 1-hydroxy-2-pyridones of the general formula
IN WHICH R1 is alkyl of 1 to 17 carbon atoms, cycloalkyl of 5 to 8 carbon atoms, cyclohexylalkyl or phenalkyl both having 1 to 3 carbon atoms in the alkylene chain or Alpha -furyl, all of which may be substituted by halogen and R2 to R4 are hydrogen or lower alkyl or 2 adjacent substituents together form a trimethylene or tetramethylene chain, and in which R1 to R4 together contain at least 2 carbon atoms, are prepared by contacting unsaturated delta -keto esters or mixtures thereof with hydroxylamine and subjecting the products to cyclization. The compounds exhibit antimycotic properties.

Abstract translation: 新的具有1至17个碳原子的烷基，5至8个碳原子的环烷基，环烷基或苯烷基，其中亚烷基链中具有1至3个碳原子的α-羟基-2-吡啶酮或α-呋喃基 所有这些可以被卤素取代，并且R 2至R 4是氢或低级烷基或2个相邻的取代基一起形成三亚甲基或四亚甲基链，并且其中R 1至R 4一起含有至少2个碳原子，通过使不饱和三 - 酯或其与羟胺的混合物，并使产物环化。