公开(公告)号：US3915984A

公开(公告)日：1975-10-28

申请号：US42286173

申请日：1973-12-07

Applicant: HOECHST AG

Inventor： GEBERT ULRICH ,  BABEJ MILOS ,  GRANZER ERNOLD

IPC: C07D233/60 ,  C07D235/06 ,  C07D521/00

CPC classification number: C07D235/06 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

Abstract: Compounds of the formula

IN WHICH R1 and R2 each stands for a hydrogen atom or together they stand for the group -CH CH-CH CH- which may carry one or more lower alkyl, halogeno-alkyl or alkoxy groups, halogen atoms or NO2-groups, and R3 and R4, independently of one another, each stands for a hydrogen atom, a lower alkyl, halogeno-alkyl, alkoxy or halogeno-alkoxy group, a halogen atom or NO2 or together they stand as a -CH CH-CH CH- group with the benzene nucleus for the naphthyl group, AND PHYSIOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AS ACTIVE SUBSTANCE.

Abstract translation: 式Ⅰ的化合物，其中R 1和R 2各自代表氢原子，或一起代表基团-CH = CH-CH = CH-，其可以携带一个或多个低级烷基，卤代烷基或烷氧基，卤素原子或 NO 2 - 基，R 3和R 4彼此独立地表示氢原子，低级烷基，卤代 - 烷基，烷氧基或卤代 - 烷氧基，卤素原子或NO 2，或者一起表示-CH = CH-CH = CH-基团与萘基的萘基，以及生理学上可接受的酸加法盐，其制备它们和作为活性物质的药物组合物的方法。

公开(公告)号：US3992538A

公开(公告)日：1976-11-16

申请号：US58818675

申请日：1975-06-19

Applicant: HOECHST AG

Inventor： TEUFEL HERMANN ,  BARTMANN WILHELM ,  BECK GERHARD ,  GRANZER ERNOLD

IPC: A61K31/15 ,  A61K20060101 ,  C07C20060101 ,  C07C67/00 ,  C07C239/00 ,  C07C251/66

CPC classification number: C07D417/04

公开(公告)号：US3915980A

公开(公告)日：1975-10-28

申请号：US42160373

申请日：1973-12-04

Applicant: HOECHST AG

Inventor： GEBERT ULRICH ,  GRANZER ERNOLD

IPC: C07D233/84 ,  C07D233/64

CPC classification number: C07D233/84

Abstract: Imidazolyl-(2)-thioalkanoic acid ester of the formula I

in which R stands for phenyl, phen-(C1-C3)alkyl, R1 stands for hydrogen or (C1-C3)-alkyl and R2 and R3 each stands for (C1-C3)-alkyl, AND THE PHYSIOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM AS ACTIVE SUBSTANCE.

Abstract translation: 式I的咪唑基 - （2） - 硫代链烷酸酯，其中R代表苯基，苯 - （C1-C3）烷基，R1代表氢或（C1-C3） - 烷基，R2和R3各自代表（C1 -C 3） - 烷基，以及生理学上可接受的酸添加剂，其制备方法及其作为活性物质的药物制剂。

公开(公告)号：US3914236A

公开(公告)日：1975-10-21

申请号：US45471374

申请日：1974-03-25

Applicant: HOECHST AG

Inventor： LERCH ULRICH ,  GRANZER ERNOLD

IPC: A61K31/47 ,  A61K31/472 ,  A61P3/06 ,  A61P3/08 ,  A61P9/10 ,  C07D217/22 ,  C07D217/24 ,  C07D227/06 ,  C07D401/04 ,  C07D521/00

CPC classification number: C07D231/12 ,  C07D217/22 ,  C07D217/24 ,  C07D233/56 ,  C07D249/08

Abstract: 1-(1-Imidazolyl)-isoquinolines of the general formula I and their physiologically tolerated salts,

IN WHICH R1, R2 and R3 represent hydrogen, alkyl of 1 to 4 carbon atoms or phenyl, R1, R2 and R3 may be identical or different, R4 represents hydrogen, alkyl of 1 to 4 carbon atoms, phenyl or chlorine, and R5 represents hydrogen, alkyl of 1 to 6 carbon atoms, cycloalkyl of 5 to 8 carbon atoms, phenyl or chlorine, a process for preparing them and pharmaceutical preparations containing them as active ingredient.

Abstract translation: 通式I的1-（1-咪唑基） - 异喹啉及其生理上耐受的盐，其中R 1，R 2和R 3表示氢，1至4个碳原子的烷基或苯基，R 1，R 2和R 3可以相同或不同 ，R4表示氢，1-4个碳原子的烷基，苯基或氯，R5表示氢，1-6个碳原子的烷基，5-8个碳原子的环烷基，苯基或氯，它们的制备方法和药物制剂 含有它们作为活性成分。