公开(公告)号：US3573287A

公开(公告)日：1971-03-30

申请号：US3573287D

申请日：1968-08-07

Applicant: HOECHST AG

Inventor： SCHORR MANFRED ,  SCHRINNER ELMAR ,  TEICHMANN KARL HORST

IPC: A61K31/44 ,  C09B26/04 ,  C07D31/42

CPC classification number: A61K31/44 ,  C09B26/04

Abstract: SUBSTITUTED P-HYDROXYPHENYL-HYDRAZONES OF THE FORMULA

1-R4,3-((4-(HO-),R1,R2-PHENYL)-NH-N=C(-R3)-)PYRIDINIUM

X(-)

IN WHICH R1 AND R2 REPRESENT HYDROGEN, HALOGEN, LOWER ALKYL OR ALKOXY, CARBOXY, CARBAMOYL, LOWER CARBALKOXY, CARBOBENZOXY, SULFOXY OR SULFAMOUL; R3 REPRESNETS HYDROGEN OR LOWER ALKYL HAVING 1 TO 3 CARBON ATOMS, R4 REPRESENTS AN ALKYL RADICAL HAVING 1 TO 12 CARBON ATOMS, WHICH MAY CARRY ONE OR SEVERAL HYDROXY, LOWER ALKOXY, CARBOXY, LOWER CARBALKOXY, CARBAMOYL, NITRILE, SULFO, LOWER SULFALKOXY AND/OR SULFAMOYL GROUPS, AND X REPRESENTS THE ANION OF A NON-TOXIC ACID, WHICH COMPOUNDS HAVE BACTERIOSTATIC PROPERTIES.

公开(公告)号：US3481928A

公开(公告)日：1969-12-02

申请号：US3481928D

申请日：1966-06-30

Applicant: HOECHST AG

Inventor： WOLF ERHARD ,  SCHRINNER ELMAR

IPC: A61K31/505 ,  C07D239/92 ,  C07D51/36 ,  C07D51/46 ,  C07D51/48

CPC classification number: A61K31/505 ,  C07D239/92

公开(公告)号：US3865820A

公开(公告)日：1975-02-11

申请号：US24428772

申请日：1972-04-14

Applicant: HOECHST AG

Inventor： SCHORR MANFRED ,  SCHRINNER ELMAR

IPC: A61K20060101 ,  A61K31/43 ,  C07D20060101 ,  C07D499/12 ,  C07D499/34 ,  C07D499/48 ,  C07D501/06 ,  C07D501/26 ,  C07D501/32 ,  C07D501/60 ,  C07D99/24

CPC classification number: C07D499/00

Abstract: Acylaminocephalosporanic acids of the formula I

wherein R1, R2 and R3 each represents hydrogen or lower alkyl radicals in which case R1 and R2 may also form together an optionally substituted alkylene radical, A represents an optionally substituted phenylene or thienyl radical, and X represents an oxygen atom or a single bond, the physiologically tolerable salts thereof, pharmaceutical preparations effective against bacterial infections containing these compounds, and a process for the manufacture.

Abstract translation: 式I的酰氨基头孢烷酸其中R 1，R 2和R 3各自表示氢或低级烷基，其中R 1和R 2也可以一起形成任选取代的亚烷基，A表示任选取代的亚苯基或噻吩基，X表示氧 原子或单键，其生理上可耐受的盐，对含有这些化合物的细菌感染有效的药物制剂及其制备方法。

公开(公告)号：US3920640A

公开(公告)日：1975-11-18

申请号：US35646673

申请日：1973-05-02

Applicant: HOECHST AG

Inventor： SCHORR MANFRED ,  WORM MANFRED ,  SCHRINNER ELMAR

IPC: C07D233/22 ,  C07D233/26 ,  C07D239/06 ,  C07D333/38 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24

CPC classification number: C07D239/06 ,  C07D233/22 ,  C07D233/26 ,  C07D333/38

Abstract: IN WHICH R1, R2 and R3 represent hydrogen or lower alkyl groups and R1 and R2 may form together an alkylene group which may be substituted, R4 represents a linear or branched alkyl radical of 1 to 5 carbon atoms, a cyclo-alkyl radical of 3 to 7 carbon atoms which may be interrupted by heteroatoms, X represents a single bond or NH, A represents a phenylene or thienylene group which may be substituted and Y represents a single bond or oxygen, and their physiologically tolerated salts; the novel compounds have very good anti-bacterial properties.

Acylamino-cephem-carboxylic acids of the general formula

Abstract translation: 酰基氨基 - 头孢烯羧酸，其通式为R 1，R 2和R 3表示氢或低级烷基，R 1和R 2可以一起形成可被取代的亚烷基，R 4表示1至5的直链或支链烷基 碳原子，可被杂原子中断的3-7个碳原子的环烷基，X表示单键或NH，A表示可被取代的亚苯基或亚噻吩基，Y表示单键或氧，以及 他们的生理耐受盐; 新型化合物具有非常好的抗菌性能。

公开(公告)号：US3600388A

公开(公告)日：1971-08-17

申请号：US3600388D

申请日：1969-07-07

Applicant: HOECHST AG

Inventor： DURCKHEIMER WALTER ,  SCHRINNER ELMAR

IPC: C07D241/52 ,  C07D51/78

CPC classification number: C07D241/52

Abstract: NEW CARBOXYLIC ACID HYDRAZIDES OF THE GENERAL FOMULA

1,4-DI-O
IN WHICH R1 IS LOWER ALKYL, PREFERABLY METHYL, AND R2 AND R3 REPRESENT HYDROGEN, LOWER ALKYL OR ALKOXY, ARE PREPARED BY REACTING A COMPOUND OF THE FORMULA

1,4-DI-O
IN WHICH R IS ALKYL, WITH HYDRAZINE HYDRATE UNDER MILD REACTION CONDITIONS. THE PRODUCTS OF THE INVENTION HAVE AN ANTIBACTERIAL ACTIVITY.