公开(公告)号：US20230210962A1

公开(公告)日：2023-07-06

申请号：US17909040

申请日：2021-03-03

Applicant: Hansa Biopharma AB

Inventor： Robert Bockermann ,  Anna-Karin Louise Robertson ,  Jiaxin LIN ,  Colin Charles ANDERSON

IPC: A61K38/48 ,  A61K38/47 ,  A61K35/17 ,  A61K39/395 ,  A61K31/69 ,  A61K31/675 ,  A61K35/28 ,  A61P37/06

CPC classification number: A61K38/4873 ,  A61K31/69 ,  A61K31/675 ,  A61K35/17 ,  A61K35/28 ,  A61K38/47 ,  A61K39/3955 ,  A61P37/06 ,  C12Y302/01096 ,  C12Y304/2201 ,  A61K2039/507

Abstract: The present invention relates to a conditioning regimen for the transplant of a cell, tissue or organ, optionally hematopoietic stem / progenitor cells, to a subject. The invention also relates to methods for the induction of hematopoietic chimerism in a subject. The invention also relates to methods for the prevention or treatment of a disease or condition in a subject, in which hematopoietic chimerism is induced in order to improve the benefit to the subject of a subsequent therapy. The subsequent therapy may be a cell, tissue or organ transplant or may a gene therapy administered using genetically modified hematopoietic stem cells/progenitor cells.