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    Protein Production
    2.
    发明申请
    Protein Production 有权
    蛋白质生产

    公开(公告)号：US20080201804A1

    公开(公告)日：2008-08-21

    申请号：US11995191

    申请日：2006-07-12

    申请人： Gilbert Gorr ,  Heike Launhardt ,  Christian Stemmer ,  Marta Rodriguez Franco

    发明人： Gilbert Gorr ,  Heike Launhardt ,  Christian Stemmer ,  Marta Rodriguez Franco

    IPC分类号： A01H5/00 ,  C12N5/10 ,  C12P21/00 ,  C12N15/82 ,  C12N1/21 ,  C12P19/26 ,  C12N1/19 ,  C12N1/13 ,  C07H21/04

    CPC分类号： C12N15/8257 ,  C12N9/1048 ,  C12N9/1085 ,  C12N9/1205 ,  C12N9/90 ,  C12N15/8245

    摘要： The present invention relates to a method for producing heterologous glycosylated proteins in non-animal eukaryotic cells such as in transformed bryophyte, yeast, ciliate or algae cells. In particular, the method relates to a method for producing glycosylated proteins comprising animal glycosylation patterns—comprising sialic acid residues—, such as pharmaceutical proteins for use in mammals, e.g. humans, in bryophyte cells such as those of Physcomitrella patens, the genetic material required therefore, such as DNA and RNA, vectors, host cells, methods of introducing genetic material there into, and uses thereof. Furthermore, the present invention relates to novel polypeptides and proteins obtained by the method according to the invention. Moreover, the present invention provides a method of producing sialic acid or CMP-sialic acid in a transformed non-mammalian eukaryotic cell, tissue or organism.

    摘要翻译： 本发明涉及在非动物真核细胞如转化的苔藓植物，酵母，细胞或藻类细胞中产生异源糖基化蛋白的方法。 特别地，该方法涉及生产糖基化蛋白质的方法，其包括含有唾液酸残基的动物糖基化模式，例如用于哺乳动物的药物蛋白质，例如， 人类，例如苔藓植物细胞，例如小立碗藓的细胞，因此需要的遗传物质，例如DNA和RNA，载体，宿主细胞，将遗传物质引入其中的方法及其用途。 此外，本发明涉及通过根据本发明的方法获得的新型多肽和蛋白质。 此外，本发明提供了在转化的非哺乳动物真核细胞，组织或生物体中产生唾液酸或CMP-唾液酸的方法。

    Transformed plant cell expressing five mammalian proteins involved in sialylation and a protein involved in galactosylation
    3.
    发明授权
    Transformed plant cell expressing five mammalian proteins involved in sialylation and a protein involved in galactosylation 有权
    转化的植物细胞表达参与唾液酸化的5种哺乳动物蛋白质和涉及半乳糖基化的蛋白质

    公开(公告)号：US07741539B2

    公开(公告)日：2010-06-22

    申请号：US11995191

    申请日：2006-07-12

    申请人： Gilbert Gorr ,  Heike Launhardt ,  Marta Rodriguez Franco ,  Christian Stemmer

    发明人： Gilbert Gorr ,  Heike Launhardt ,  Marta Rodriguez Franco ,  Christian Stemmer

    IPC分类号： A01H5/00 ,  C12N15/82

    CPC分类号： C12N15/8257 ,  C12N9/1048 ,  C12N9/1085 ,  C12N9/1205 ,  C12N9/90 ,  C12N15/8245

    摘要： The present invention relates to a method for producing heterologous glycosylated proteins in non-animal eukaryotic cells such as in transformed bryophyte, yeast, ciliate or algae cells. In particular, the method relates to a method for producing glycosylated proteins comprising animal glycosylation patterns—comprising sialic acid residues—, such as pharmaceutical proteins for use in mammals, e.g. humans, in bryophyte cells such as those of Physcomitrella patens, the genetic material required therefore, such as DNA and RNA, vectors, host cells, methods of introducing genetic material there into, and uses thereof. Furthermore, the present invention relates to novel polypeptides and proteins obtained by the method according to the invention. Moreover, the present invention provides a method of producing sialic acid or CMP-sialic acid in a transformed non-mammalian eukaryotic cell, tissue or organism.

    摘要翻译： 本发明涉及在非动物真核细胞如转化的苔藓植物，酵母，细胞或藻类细胞中产生异源糖基化蛋白的方法。 特别地，该方法涉及生产糖基化蛋白质的方法，其包括含有唾液酸残基的动物糖基化模式，例如用于哺乳动物的药物蛋白质，例如， 人类，例如苔藓植物细胞，例如小立碗藓的细胞，因此需要的遗传物质，例如DNA和RNA，载体，宿主细胞，将遗传物质引入其中的方法及其用途。 此外，本发明涉及通过根据本发明的方法获得的新型多肽和蛋白质。 此外，本发明提供了在转化的非哺乳动物真核细胞，组织或生物体中产生唾液酸或CMP-唾液酸的方法。