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公开(公告)号:US4950651A
公开(公告)日:1990-08-21
申请号:US725146
申请日:1985-04-19
申请人: Helga Suli , Kalman Medzihradszky , Hedvig Medzihradszky nee Schweiger , Karoly Lapis , Laszlo Kopper , Andras Jeney
发明人: Helga Suli , Kalman Medzihradszky , Hedvig Medzihradszky nee Schweiger , Karoly Lapis , Laszlo Kopper , Andras Jeney
IPC分类号: A61K31/17 , A61K38/00 , A61K38/07 , A61P35/00 , A61P35/02 , C07C67/00 , C07C239/00 , C07C275/68 , C07K5/078 , C07K5/09 , C07K5/103 , C07K5/117 , C07K14/595 , C07K14/685 , C07K14/695
CPC分类号: C07K5/0815 , C07K14/595 , C07K14/685 , C07K14/695 , A61K38/00
摘要: The invention relates to new peptide derivatives of the general Formula I ##STR1## wherein R is a group derived from any oligopeptide by removing a terminal amino group, or--if the oligopeptide comprises a diamino carboxylic acid--the amino group in the .omega.-position, or the terminal and .omega.-amino groups; andstands for the integral number 1 or 2and acid addition slats thereof and a process for the preparation thereof.The new compounds of the general Formula I exhibit antitumor activity.
摘要翻译: 本发明涉及通式I的新肽衍生物(I),其中R是通过除去末端氨基衍生自任何寡肽的基团,或 - 如果寡肽包含二氨基羧酸 - 氨基 ω-位,或末端和ω-氨基; 并代表整数1或2及其酸添加板条及其制备方法。 通式Ⅰ的新化合物具有抗肿瘤活性。