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    Thiazolidine compounds and pharmaceutical compositions exhibiting thrombopoietin receptor agonism
    1.
    发明授权
    Thiazolidine compounds and pharmaceutical compositions exhibiting thrombopoietin receptor agonism 失效
    噻唑烷化合物和显示血小板生成素受体激动作用的药物组合物

    公开(公告)号：US07026334B1

    公开(公告)日：2006-04-11

    申请号：US10048008

    申请日：2000-07-24

    申请人： Hiroshi Takemoto ,  Masami Takayama ,  Takeshi Shiota

    发明人： Hiroshi Takemoto ,  Masami Takayama ,  Takeshi Shiota

    IPC分类号： A61K31/427 ,  C07D417/12

    CPC分类号： C07D277/20 ,  C07D277/54 ,  C07D277/82 ,  C07D417/12 ,  C07D417/14

    摘要： Pharmaceutical compositions containing as an active ingredient compounds of the general formula (I), prodrugs of the same, pharmaceutically acceptable salts of both, or solvates of them and exhibiting thrombopoietin receptor agonism: wherein X1 is optionally substituted heteroaryl or the like; Y1 is —NRACO— (CH2)0-2— or the like (wherein RA is a hydrogen or the like); Z1 is optionally substituted arylene or the like; and A1 is a ring represented by general formula (II) or (III):

    摘要翻译： 含有作为活性成分的通式（I）化合物，其前体药物，它们的药学上可接受的盐或它们的溶剂合物并且表现出血小板生成素受体激动剂的药物组合物：其中X 1是任选取代的 杂芳基等; Y 1是-NR A - （CH 2）2 - 或其类似物（其中R A是氢等等）; Z 1是任选取代的亚芳基等; 和A 1是由通式（II）或（III）表示的环：

    Compounds exhibiting thrombopoietin receptor agonism
    2.
    发明授权
    Compounds exhibiting thrombopoietin receptor agonism 失效
    表现出血小板生成素受体激动作用的化合物

    公开(公告)号：US07582665B2

    公开(公告)日：2009-09-01

    申请号：US10169362

    申请日：2001-01-23

    申请人： Hiroshi Takemoto ,  Takeshi Shiota ,  Masami Takayama

    发明人： Hiroshi Takemoto ,  Takeshi Shiota ,  Masami Takayama

    IPC分类号： A61K31/425 ,  C07D277/593 ,  A01N43/78

    CPC分类号： C07D285/16 ,  A61K31/426 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/5377 ,  C07D231/40 ,  C07D249/14 ,  C07D277/46 ,  C07D277/82 ,  C07D285/18 ,  C07D333/38 ,  C07D417/04 ,  C07D417/14

    摘要： Pharmaceutical compositions containing as an active ingredient compounds of the general formula (I), prodrugs of the same, pharmaceutically acceptable salts of both, or solvates of them and exhibiting thrombopoietin receptor agonism: X1—Y1-Z1-W1  (I) wherein X1 is optionally substituted aryl, optionally substituted heteroaryl or the like; Y1 is —NRACO—(CH2)0-2— or the like (wherein RA is a hydrogen or the like); Z1 is optionally substituted phenylene or the like; and W1 is a group represeted by the below formula: wherein R1, R2, R3, and R4 are each independently a hydrogen atom, optionally substituted lower alkyl or the like, a broken line ( - - - ) represents the presence or absence of bond.

    摘要翻译： 含有作为活性成分的通式（I）的化合物，其前药，它们的药学上可接受的盐或它们的溶剂合物并且表现出血小板生成素受体激动作用的药物组合物：<？in-line-formula description =“In-line X1-Y1-Z1-W1（I）<？in-line-formula description =“In-line formula”end =“tail”？>其中X1为任选取代的芳基，任选取代 杂芳基等; Y1是-NRACO-（CH 2）0-2-等（其中RA是氢等）; Z1是任选取代的亚苯基等; 并且W 1是由下式表示的基团：其中R 1，R 2，R 3和R 4各自独立地为氢原子，任选取代的低级烷基等，虚线（ - - - ）表示键的存在或不存在 。

    Cyclic compounds exhibiting thrombopoietin receptor agonism
    3.
    发明授权
    Cyclic compounds exhibiting thrombopoietin receptor agonism 失效
    表现出血小板生成素受体激动的循环化合物

    公开(公告)号：US07169931B2

    公开(公告)日：2007-01-30

    申请号：US10470002

    申请日：2002-01-25

    申请人： Hiroshi Takemoto ,  Masami Takayama ,  Yutaka Yoshida

    发明人： Hiroshi Takemoto ,  Masami Takayama ,  Yutaka Yoshida

    IPC分类号： C07D277/46 ,  A61K31/426

    CPC分类号： A61K31/4709 ,  A61K31/426 ,  A61K31/427 ,  A61K31/433 ,  A61K31/506 ,  C07D277/46 ,  C07D417/12

    摘要： Pharmaceutical compositions containing as an active ingredient compounds of the general formula (I), prodrugs of the same, pharmaceutically acceptable salts of both, or solvates of them and exhibiting thrombopoietin receptor agonism: X1—Y1-Z1   (I) wherein X1 is optionally substituted aryl, optionally substituted heteroaryl or the like; Y1 is —NRACO—(CH2)0-2— or the like (wherein RA is hydrogen atom or the like); and Z1 is a cyclic group fused the same or different two ring selected from optionally substituted carbocyclic group and optionally substituted heterocyclic group.

    摘要翻译： 含有作为活性成分的通式（I）的化合物，其前药，它们的药学上可接受的盐或它们的溶剂合物并且表现出血小板生成素受体激动作用的药物组合物：<？in-line-formula description =“In-line 公式“end =”lead“？> X <1> 在线公式描述= “In-line Formulas”end =“tail”？>其中X 1是任选取代的芳基，任选取代的杂芳基等; Y 1是-NR A - （CH 2）2 - 或其类似物（其中R A是氢原子等）; Z 1是稠合选自任选取代的碳环基团和任选取代的杂环基团的相同或不同的两个环的环状基团。

    Analyzer of ultrasonic flaw detection image
    4.
    发明授权
    Analyzer of ultrasonic flaw detection image 有权
    超声波探伤图像分析仪

    公开(公告)号：US08630447B2

    公开(公告)日：2014-01-14

    申请号：US13146991

    申请日：2010-02-23

    申请人： Tomoaki Kitagawa ,  Hiroshi Takemoto

    发明人： Tomoaki Kitagawa ,  Hiroshi Takemoto

    IPC分类号： G06K9/00

    CPC分类号： G01N29/069 ,  G01N29/4427 ,  G01N2291/2694 ,  G06T7/0008 ,  G06T7/001

    摘要： A flaw detection image analyzer (10) takes in an inspection procedure command stored in a flaw detection condition database (40), takes in a flaw detection image signal corresponding to a flaw detection image indicated by the taken inspection procedure command from a database (50) for flaw detection image signal, and displays the flaw detection image based on the flaw detection image signal on a display (30), with a display range and a contrast indicated by the inspection procedure command in an arrangement pattern of image indicated by the inspection procedure command. Consequently, optimum images can be displayed sequentially with optimum arrangement pattern, optimum display range and contrast according to a flaw to be inspected when a flaw is detected by observing an ultrasonic flaw detection image.

    摘要翻译： 探伤图像分析器（10）接收存储在缺陷检测条件数据库（40）中的检查程序指令，从数据库（50）接收与由所检查过程命令指示的缺陷检测图像相对应的缺陷检测图像信号 ），并且以显示范围和由检查程序指令指示的对比度在显示器（30）上显示出以探伤指示的图像的布置图案为基础的探伤图像信号的缺陷检测图像 过程命令。 因此，当通过观察超声波探伤图像检测到缺陷时，可以根据要检查的缺陷以最佳布置图案，最佳显示范围和对比度顺序地显示最佳图像。

    REPORTER GENE ASSAY
    5.
    发明申请
    REPORTER GENE ASSAY 审中-公开
    报告基因测定

    公开(公告)号：US20090111098A1

    公开(公告)日：2009-04-30

    申请号：US11908095

    申请日：2006-03-03

    申请人： Koji Enomoto ,  Yoshito Numata ,  Hiroshi Takemoto

    发明人： Koji Enomoto ,  Yoshito Numata ,  Hiroshi Takemoto

    IPC分类号： C12Q1/68 ,  C12N5/10 ,  C12N15/63

    CPC分类号： C12N15/1086 ,  C12Q1/6897

    摘要： The invention provides a more highly accurate assay for measuring the transcriptional activity of a test substance. Disclosed is a reporter gene assay, comprising the steps of contacting a cell having a vector wherein a reporter gene containing a gene encoding an epitope tag is ligated downstream to a recognition sequence of a transcription factor and a nucleotide sequence necessary for transcriptional initiation, with a test substance and detection antibodies; detecting a phenomenon caused by the two kinds of detection antibodies coming close to each other; and correlating the detected phenomenon with the effect of the test substance on transcriptional regulatory mechanism.

    摘要翻译： 本发明提供了用于测量测试物质的转录活性的更高精度的测定。 公开了一种报告基因测定方法，其包括以下步骤：将含有编码表位标签的基因的报告基因的下游连接到转录因子的识别序列和转录起始必需的核苷酸序列的载体接触， 检测物质和检测抗体; 检测由两种接近检测抗体引起的现象; 并将检测到的现象与测试物质对转录调控机制的影响相关联。

    Test apparatus for testing multiple electronic devices
    7.
    发明授权
    Test apparatus for testing multiple electronic devices 有权
    用于测试多个电子设备的测试装置

    公开(公告)号：US07372288B2

    公开(公告)日：2008-05-13

    申请号：US11447679

    申请日：2006-06-06

    申请人： Hiroshi Takemoto

    发明人： Hiroshi Takemoto

    IPC分类号： G01R31/26 ,  H03K17/16 ,  H01R13/66 ,  H03P5/04

    CPC分类号： G01R31/31926

    摘要： There is disclosed a test apparatus including a driver that outputs a test signal, a first switch that is provided between the driver and a terminal of the first device under test, a second switch that is provided between the driver and a terminal of the second device under test, a first termination resistor that terminates the output signal from the driver in the terminal of the first device under test, a second termination resistor that terminates the output signal from the driver in the terminal of the second device under test, and a substitute resistor that is decoupled from the driver when the driver is connected to the terminals of the first and second device under test, and is connected to the driver when the driver and the terminal of the second device under test are disconnected.

    摘要翻译： 公开了一种测试装置，其包括输出测试信号的驱动器，设置在驱动器和被测试的第一设备的终端之间的第一开关，设置在驱动器和第二设备的端子之间的第二开关 测试中的第一终端电阻器，其终止来自被测试的第一器件的端子中的驱动器的输出信号，第二终端电阻器，其终止来自被测试的第二器件的端子中的驱动器的输出信号，以及替代 电阻器，当驱动器连接到被测试的第一和第二设备的端子时，与驱动器分离，并且当被测试的第二设备的驱动器和终端断开时，连接到驱动器。

    Front-loading disk player
    8.
    发明授权
    Front-loading disk player 失效
    前端盘播放器

    公开(公告)号：US06671245B2

    公开(公告)日：2003-12-30

    申请号：US10319537

    申请日：2002-12-16

    申请人： Shigekazu Wada ,  Hiroshi Takemoto ,  Yasumitsu Suzuki ,  Kouichi Yaeguchi ,  Tohru Kanegae

    发明人： Shigekazu Wada ,  Hiroshi Takemoto ,  Yasumitsu Suzuki ,  Kouichi Yaeguchi ,  Tohru Kanegae

    IPC分类号： G11B3302

    CPC分类号： G11B17/057 ,  G11B17/0405

    摘要： A front-loading disk player includes a player assembly for playing a disk having been carried thereto; a front panel positioned in front of said player assembly and having a slot for receiving therein either one of a bare disk and a cartridge disk holding a recording disk therein; a cover section for blocking said slot having a through hole; and a lock unit for locking an operation of opening said slot. The lock unit includes a locking assembly for fixing the cover section at a position to close the slot and an unlocking rivet provided into the through hole. The unlocking rivet is configured to move in a same direction in which the cartridge disk is inserted in the slot so as to cause the locking assembly to be released from the cover section.

    摘要翻译： 前装载盘播放器包括用于播放已经被携带的盘的播放器组件; 位于所述播放器组件前面的前面板，并且具有用于在其中容纳裸盘和保持其中的记录盘的盒盘中的一个的槽; 用于阻挡具有通孔的所述槽的盖部; 以及用于锁定打开所述槽的操作的锁定单元。 锁定单元包括用于将盖部固定在关闭槽的位置的锁定组件和设置在通孔中的解锁铆钉。 解锁铆钉被配置成沿着相同的方向移动盒盘插入槽中，以使锁定组件从盖部分释放。