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    SUSTAINED RELEASE DRUG DELIVERY DEVICES, METHODS OF USE, AND METHODS OF MANUFACTURING THEREOF
    1.
    发明申请
    SUSTAINED RELEASE DRUG DELIVERY DEVICES, METHODS OF USE, AND METHODS OF MANUFACTURING THEREOF 有权
    持续释放药物递送装置，使用方法及其制造方法

    公开(公告)号：US20100119580A1

    公开(公告)日：2010-05-13

    申请号：US12689956

    申请日：2010-01-19

    申请人： Hong Guo ,  Paul Ashton

    发明人： Hong Guo ,  Paul Ashton

    IPC分类号： A61K9/00 ,  A61K47/32 ,  A61K38/02 ,  A61K38/22 ,  A61K31/58 ,  A61K31/7064 ,  A61K31/52 ,  A61K31/522 ,  A61K31/7072

    CPC分类号： A61K9/20 ,  A61F9/0017 ,  A61K9/0051 ,  A61K9/0092 ,  A61K9/5089 ,  A61K31/58 ,  Y10T29/49888

    摘要： A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir including the effective agent, an impermeable tube which encloses portions of the reservoir, and a permeable member at an end of the tube.

    摘要翻译： 提供了一种用于治疗哺乳动物生物体以获得所需局部或全身生理或药理作用的方法和装置。 该方法包括向需要这种治疗的哺乳动物生物体施用持续释放药物递送系统，其中需要释放有效药剂并允许有效药剂以受控的方式通过该装置。 该装置包括包含有效试剂的内芯或储存器，封闭储存器的一部分的不可渗透管和在管的端部处的可渗透构件。

    Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
    2.
    发明授权
    Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof 有权
    缓释药物递送装置，使用方法及其制造方法

    公开(公告)号：US06375972B1

    公开(公告)日：2002-04-23

    申请号：US09558207

    申请日：2000-04-26

    申请人： Hong Guo ,  Paul Ashton

    发明人： Hong Guo ,  Paul Ashton

    IPC分类号： A61F900

    CPC分类号： A61K9/20 ,  A61F9/0017 ,  A61K9/0051 ,  A61K9/0092 ,  A61K9/5089 ,  A61K31/58 ,  Y10T29/49888

    摘要： A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir including the effective agent, an impermeable tube which encloses portions of the reservoir, and a permeable member at an end of the tube.

    摘要翻译： 提供了一种用于治疗哺乳动物生物体以获得所需局部或全身生理或药理作用的方法和装置。 该方法包括向需要这种治疗的哺乳动物生物体施用持续释放药物递送系统，其中需要释放有效药剂并允许有效药剂以受控的方式通过该装置。 该装置包括包含有效试剂的内芯或储存器，封闭储存器的一部分的不可渗透管和在管的端部处的可渗透构件。

    Compositions and Methods for Controlled Release of Agents
    3.
    发明申请
    Compositions and Methods for Controlled Release of Agents 审中-公开
    药剂控制释放的组成和方法

    公开(公告)号：US20160075776A1

    公开(公告)日：2016-03-17

    申请号：US14855946

    申请日：2015-09-16

    申请人： Paul Ashton ,  Hong Guo ,  Leigh T. Canham ,  Dinesh Nadarassan

    发明人： Paul Ashton ,  Hong Guo ,  Leigh T. Canham ,  Dinesh Nadarassan

    IPC分类号： C07K16/24 ,  A61K9/00 ,  C07K16/22 ,  A61K38/22 ,  A61K9/16 ,  C07K14/715

    CPC分类号： A61K38/22 ,  A61K9/0051 ,  A61K47/02 ,  C07K14/7151 ,  C07K2319/30

    摘要： This invention discloses reservoirs, such as implants for delivering therapeutic agents, particularly large molecules such as proteins and antibodies. The reservoirs may comprise a porous silicon-based carrier material impregnated with the therapeutic agent. The reservoir may be used in vitro or in vivo to maintain an equilibrium concentration of a therapeutic agent over an intended period of time such as over multiple days, weeks, months, or years. Additionally, the reservoir may be reloaded with additional therapeutic agent. These reservoirs may be used for treating or preventing conditions of a subject such as chronic diseases.

    摘要翻译： 本发明公开了诸如用于递送治疗剂的植入物，特别是大分子如蛋白质和抗体的储库。 储存器可以包含浸渍有治疗剂的多孔硅基载体材料。 储存器可以在体外或体内使用以维持治疗剂在预期的时间段内的平衡浓度，例如超过几天，几周，几个月或几年。 此外，储存器可以用另外的治疗剂重新装载。 这些储存器可用于治疗或预防受试者例如慢性疾病的病症。

    Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
    7.
    发明申请
    Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof 审中-公开
    缓释药物递送装置，使用方法及其制造方法

    公开(公告)号：US20050186279A1

    公开(公告)日：2005-08-25

    申请号：US11081142

    申请日：2005-03-15

    申请人： Hong Guo ,  Paul Ashton

    发明人： Hong Guo ,  Paul Ashton

    IPC分类号： A61F9/007 ,  A61K9/00 ,  A61K9/22 ,  A61K31/4422 ,  A61K31/58 ,  A61M37/00 ,  A61P9/12 ,  A61P27/02 ,  A61P29/00 ,  A61K9/24

    CPC分类号： A61K9/20 ,  A61F9/0017 ,  A61K9/0051 ,  A61K9/0092 ,  A61K9/5089 ,  A61K31/58 ,  Y10T29/49888

    摘要： A method and device for treating a mammalian organism to obtain a desired local or systemic physiological or pharmacological effect is provided. The method includes administering a sustained release drug delivery system to a mammalian organism in need of such treatment at an area wherein release of an effective agent is desired and allowing the effective agent to pass through the device in a controlled manner. The device includes an inner core or reservoir including the effective agent, an impermeable tube which encloses portions of the reservoir, and a permeable member at an end of the tube.

    摘要翻译： 提供了一种用于治疗哺乳动物生物体以获得所需局部或全身生理或药理作用的方法和装置。 该方法包括向需要这种治疗的哺乳动物生物体施用持续释放药物递送系统，其中需要释放有效药剂并允许有效药剂以受控的方式通过该装置。 该装置包括包含有效试剂的内芯或储存器，封闭储存器的一部分的不可渗透管和在管的端部处的可渗透构件。

    Method for treating and/or preventing retinal diseases with sustained release corticosteroids
    8.
    发明授权
    Method for treating and/or preventing retinal diseases with sustained release corticosteroids 有权
    用持续释放的皮质类固醇治疗和/或预防视网膜疾病的方法

    公开(公告)号：US06548078B2

    公开(公告)日：2003-04-15

    申请号：US09735636

    申请日：2000-12-14

    申请人： Hong Guo ,  Paul Ashton

    发明人： Hong Guo ,  Paul Ashton

    IPC分类号： A61F200

    CPC分类号： A61K31/573 ,  A61K9/0051

    摘要： The present invention relates to a method for administering a corticosteroid to a posterior segment of an eye. In the method, a sustained release device is implanted to deliver the corticosteroid to the eye. The aqueous corticosteroid concentration remains less than vitreous corticosteroid concentration during release of the corticosteroid from the device.

    摘要翻译： 本发明涉及向眼后段施用皮质类固醇的方法。 在该方法中，植入持续释放装置以将皮质类固醇递送至眼睛。 在皮质类固醇释放期间，皮质类固醇水溶液的浓度仍然低于玻璃体皮质类固醇浓度。

    Injectable sustained release delivery devices
    9.
    发明授权
    Injectable sustained release delivery devices 有权
    可注射持续释放递送装置

    公开(公告)号：US08871241B2

    公开(公告)日：2014-10-28

    申请号：US10714549

    申请日：2003-11-13

    申请人： Kang-Jye Chou ,  Hong Guo ,  Paul Ashton ,  Robert W. Shimizu ,  David A. Watson

    发明人： Kang-Jye Chou ,  Hong Guo ,  Paul Ashton ,  Robert W. Shimizu ,  David A. Watson

    IPC分类号： A61F2/00 ,  A61K9/28 ,  A61K9/00 ,  A61K31/58 ,  A61K45/06 ,  A61K9/24 ,  A61K31/7072 ,  A61K9/20

    CPC分类号： A61K9/0004 ,  A61K9/0024 ,  A61K9/0051 ,  A61K9/0092 ,  A61K9/204 ,  A61K9/2086 ,  A61K9/209 ,  A61K9/284 ,  A61K9/2853 ,  A61K9/2886 ,  A61K31/58 ,  A61K31/7072 ,  A61K45/06 ,  A61K2300/00

    摘要： An injectable drug delivery device includes a core containing one or more drugs and one or more polymers. The core may be surrounded by one or more polymer outer layers (referred to herein as “coatings,” “skins,” or “outer layers”). In certain embodiments, the device is formed by extruding or otherwise preforming a polymeric skin for a drug core. The drug core may be co-extruded with the skin, or inserted into the skin after the skin has been extruded, and possibly cured. In other embodiments, the drug core may be coated with one or more polymer coatings. These techniques may be usefully applied to fabricate devices having a wide array of drug formulations and skins that can be selected to control the release rate profile and various other properties of the drugs in the drug core in a form suitable for injection using standard or non-standard gauge needles. The device may be formed by combining at least one polymer, at least one drug, and at least one liquid solvent to form a liquid suspension or solution wherein, upon injection, such suspension or solution under goes a phase change and forms a gel. The configuration may provide for controlled release of the drug(s) for an extended period.

    摘要翻译： 可注射药物递送装置包括含有一种或多种药物的核心和一种或多种聚合物。 芯可以被一个或多个聚合物外层（本文中称为“涂层”，“表皮”或“外层”）包围。 在某些实施方案中，通过挤出或以其它方式预先形成用于药物核心的聚合物皮肤来形成装置。 药物核心可以与皮肤共挤出，或者在皮肤挤出后可以将其插入皮肤中，并可能固化。 在其它实施方案中，药物核心可以涂覆有一种或多种聚合物涂层。 这些技术可以有效地应用于制造具有广泛的药物制剂和皮肤的装置，其可以选择为以适合于使用标准或非标准的注射剂的形式控制药物核心中的药物的释放速率分布和各种其它性质， 标准规格针。 该装置可以通过组合至少一种聚合物，至少一种药物和至少一种液体溶剂以形成液体悬浮液或溶液而形成，其中在注射时，这样的悬浮液或溶液在变相下形成凝胶。 该配置可以提供长时间的药物的控制释放。

    POROUS SILICON DRUG-ELUTING PARTICLES
    10.
    发明申请
    POROUS SILICON DRUG-ELUTING PARTICLES 有权
    多孔硅胶药物颗粒

    公开(公告)号：US20100278931A1

    公开(公告)日：2010-11-04

    申请号：US12773127

    申请日：2010-05-04

    申请人： Paul Ashton ,  Hong Guo ,  Jianbing Chen ,  Leigh Canham

    发明人： Paul Ashton ,  Hong Guo ,  Jianbing Chen ,  Leigh Canham

    IPC分类号： A61K9/14 ,  A61K31/58 ,  A61P27/02

    CPC分类号： A61K31/58 ,  A61K9/0048 ,  A61K9/0097

    摘要： The invention provides a biodegradable drug-eluting particle useful for the delivery of diagnostic or therapeutic agents. In certain embodiments, the drug-eluting particle of the invention comprises a biodegradable porous silicon body, a reservoir formed within the porous silicon body having at least one opening to an exterior of the body, wherein the reservoir contains a therapeutic or diagnostic agent, and an agent-permeable seal disposed over the at least one opening. The invention further provides a method for treating a patient to obtain a desired local or systemic physiological or pharmacological effect comprising administering a sustained release drug delivery particle of the invention. The invention also provides methods of fabricating a drug-eluting particle for releasing therapeutic agents

    摘要翻译： 本发明提供了可用于递送诊断或治疗剂的可生物降解的药物洗脱颗粒。 在某些实施方案中，本发明的药物洗脱颗粒包括可生物降解的多孔硅体，形成在多孔硅体内的储存器，其具有至少一个开口到本体的外部，其中储存器包含治疗剂或诊断剂，以及 设置在所述至少一个开口上方的渗透剂的密封件。 本发明进一步提供了一种治疗患者以获得所需局部或全身生理或药理作用的方法，包括施用本发明的缓释药物递送颗粒。 本发明还提供了制备用于释放治疗剂的药物洗脱颗粒的方法