公开(公告)号：US11319273B2

公开(公告)日：2022-05-03

申请号：US14689827

申请日：2015-04-17

Applicant: Howard University

Inventor： Evaristus A. Nwulia ,  Amol Kulkarni

IPC: C07C49/255 ,  A61K31/12 ,  C07D207/36 ,  A61K31/40 ,  C07D307/60 ,  A61K31/341 ,  C07D333/32 ,  A61K31/381 ,  C07C323/22 ,  A61K45/06 ,  A61M31/00 ,  A61K31/122 ,  A61K31/4025 ,  A61K9/00 ,  C07D237/14 ,  C07D265/02 ,  C07D279/02

Abstract: Compounds having formulas (I) to (VIII), salts thereof, or combinations thereof and pharmaceutical compositions comprising one or more these compounds are described herein for the treatment of HIV and neurodegenerative effects caused by HIV. Also provided herein are methods and a kit for inhibiting HIV-1, treating latent HIV in the brain, and preventing HIV-mediated cognitive decline and HIV dementia comprising administering the compounds having the formulas (I) to (VIII) and pharmaceutical compositions comprising the compounds having these formulas. The compounds having formulas I through VIII are curcumin analogs which are advantageously characterized as having anti-retroviral, neuroprotective, anti-glucosidase, and anti-HIV integrase properties. In one aspect, the pharmaceutical composition is delivered intranasally.

公开(公告)号：US20200270214A1

公开(公告)日：2020-08-27

申请号：US16634567

申请日：2019-07-26

Applicant: Emory University ,  Mercer University ,  Howard University ,  Union University

Inventor： Osman Güner ,  Bernard Lassegue ,  Kathy Griendling ,  Qian Xu ,  David Brown ,  J. Phillip Bowen ,  Amol Kulkarni ,  E. Blake Watkins

IPC: C07D239/26 ,  C07D213/50 ,  C07D213/65 ,  C07D215/14 ,  C07D307/54

Abstract: This disclosure relates to compounds and methods of treating or preventing a Nox related disease or condition comprising administering to a subject in need thereof a Nox inhibitor or pharmaceutical compositions comprising a Nox inhibitor disclosed herein, derivatives, or compounds disclosed herein optionally substituted with one or more substitutes including optional salt and prodrug forms. In certain embodiments, this disclosure relates to sulfonylurea compounds and uses reported herein.

公开(公告)号：US11236053B2

公开(公告)日：2022-02-01

申请号：US16634567

申请日：2018-07-26

Applicant: Emory University ,  Mercer University ,  Howard University ,  Union University

Inventor： Osman Güner ,  Bernard Lassegue ,  Kathy Griendling ,  Qian Xu ,  David Brown ,  J. Phillip Bowen ,  Amol Kulkarni ,  E. Blake Watkins

IPC: C07D239/26 ,  C07D213/50 ,  C07D307/54 ,  C07D215/14 ,  C07D213/65

Abstract: This disclosure relates to compounds and methods of treating or preventing a Nox related disease or condition comprising administering to a subject in need thereof a Nox inhibitor or pharmaceutical compositions comprising a Nox inhibitor disclosed herein, derivatives, or compounds disclosed herein optionally substituted with one or more substitutes including optional salt and prodrug forms. In certain embodiments, this disclosure relates to sulfonylurea compounds and uses reported herein.

公开(公告)号：US20160009623A1

公开(公告)日：2016-01-14

申请号：US14689827

申请日：2015-04-17

Applicant: Howard University

Inventor： Evaristus A. Nwulia ,  Amol Kulkarni

IPC: C07C49/255 ,  C07D265/02 ,  C07D307/60 ,  C07D207/36 ,  C07D333/32 ,  C07D279/02 ,  C07D237/14

CPC classification number: C07C49/255 ,  A61K9/0043 ,  A61K31/12 ,  A61K31/122 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/4025 ,  A61K45/06 ,  A61M31/00 ,  C07C323/22 ,  C07D207/36 ,  C07D237/14 ,  C07D265/02 ,  C07D279/02 ,  C07D307/60 ,  C07D333/32

Abstract: Compounds having formulas (I) to (VIII), salts thereof, or combinations thereof and pharmaceutical compositions comprising one or more these compounds are described herein for the treatment of HIV and neurodegenerative effects caused by HIV. Also provided herein are methods and a kit for inhibiting HIV-1, treating latent HIV in the brain, and preventing HIV-mediated cognitive decline and HIV dementia comprising administering the compounds having the formulas (I) to (VIII) and pharmaceutical compositions comprising the compounds having these formulas. The compounds having formulas I through VIII are curcumin analogs which are advantageously characterized as having anti-retroviral, neuroprotective, anti-glucosidase, and anti-HIV integrase properties. In one aspect, the pharmaceutical composition is delivered intranasally.

Abstract translation: 本文描述了具有式（I）至（VIII）的化合物，其盐或其组合以及包含一种或多种这些化合物的药物组合物用于治疗由HIV引起的HIV和神经变性作用。 本文还提供了用于抑制HIV-1，治疗脑中潜伏性HIV并防止HIV介导的认知衰退和HIV痴呆的方法和试剂盒，其包括施用具有式（I）至（VIII）的化合物和包含 具有这些式的化合物。 具有式I至VIII的化合物是姜黄素类似物，其有利地表征为具有抗逆转录病毒，神经保护，抗葡萄糖苷酶和抗HIV整合酶性质。 一方面，药物组合物是鼻内递送的。