公开(公告)号：US08541378B2

公开(公告)日：2013-09-24

申请号：US12792186

申请日：2010-06-02

申请人： Hyung Jun Ahn ,  Ick Chan Kwon ,  Kuiwon Choi ,  Kwangmyeng Kim ,  Inchan Youn ,  Sehoon Kim

发明人： Hyung Jun Ahn ,  Ick Chan Kwon ,  Kuiwon Choi ,  Kwangmyeng Kim ,  Inchan Youn ,  Sehoon Kim

IPC分类号： A61K38/10

CPC分类号： C07K14/76 ,  A61K47/643 ,  C07K14/765 ,  C07K2319/20

摘要： The present invention relates to recombinant albumins fused with poly-cysteine peptide and methods for preparing the same, more precisely recombinant albumins in which cysteines that can be used for drug binding are amplified at N-terminal and C-terminal of the albumin and methods for preparing the same. The recombinant albumin of the present invention demonstrates improved albumin-drug conjugation efficiency when it is used for drug delivery system, indicating that it can effectively deliver a large amount of drug to a target tissue. At the same time, the recombinant albumin of the present invention can be used as an excellent drug deliverer with reduced side effects, compared with the conventional albumin carriers, by regulating the amount of drug conjugated to each unit of albumin by regulating the number of cysteine fused thereto. In addition, the recombinant albumin of the present invention can be used for the screening of a novel drug and for the non-invasive real-time diagnosis and treatment of disease by combining with a fluorescent material or a contrast agent for molecular imaging.

摘要翻译： 本发明涉及与多聚半胱氨酸肽融合的重组白蛋白及其制备方法，更准确地说，重组白蛋白，其中可用于药物结合的半胱氨酸在白蛋白的N末端和C末端扩增， 准备一样 本发明的重组白蛋白在用于药物递送系统时表现出改善的白蛋白 - 药物共轭效率，表明其可有效地将大量药物递送至靶组织。 同时，与常规白蛋白载体相比，本发明的重组白蛋白可以用作优异的药物递送剂，通过调节半胱氨酸数目调节与每单位白蛋白结合的药物量 融合。 此外，本发明的重组白蛋白可以用于筛选新药和用于分子成像的荧光材料或造影剂的非侵入性实时诊断和治疗疾病。

公开(公告)号：US06585666B2

公开(公告)日：2003-07-01

申请号：US09916649

申请日：2001-07-30

申请人： Jun-kyo Suh ,  Freddie H. Fu ,  Inchan Youn

发明人： Jun-kyo Suh ,  Freddie H. Fu ,  Inchan Youn

IPC分类号： A61B5103

CPC分类号： A61B5/4514 ,  A61B5/103 ,  A61B5/4528 ,  A61B8/08

摘要： A mechanical diagnostic probe is used to determine the thickness of articular cartilage, so that any degeneration in the articular cartilage can be detected at an early stage. The probe advantageously allows for calibrating the speed of the ultrasound in situ thereby allowing for more accurate measurements of the tissue thickness. The probe also can be used to monitor the condition of the cartilage after surgery and/or after or during physical rehabilitation of the cartilage. The probe is comprised of a probe handle and a probe, which is comprised of an ultrasonic transducer, strain-gauges, and a linear displacement actuator. A predetermined displacement then is applied to the indenter tip and a computer program is then used to analyze the results.