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公开(公告)号：US20250084392A1
公开(公告)日：2025-03-13
申请号：US18725912
申请日：2023-01-04
Applicant: INSCRIPTA, INC.
Inventor： Brian Chaikind , Christopher Lim
Abstract: This invention relates to compositions of matter, methods and instruments for directly recruiting repair templates to CRISPR nucleases to stimulate homology-directed repair. Molecular “tethers” are described which result in an increase in the local concentration of repair templates at the site of the double-strand break made by a nuclease, thereby enhancing the rate of homology directed repair and suppressing undesired edits.
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