公开(公告)号：US20240020529A1

公开(公告)日：2024-01-18

申请号：US18034149

申请日：2021-10-27

Applicant: ISP INVESTMENTS LLC

Inventor： Yunxia BI ,  Thomas DURIG ,  Solomon Howard JACOBSON

IPC: G06N3/08

CPC classification number: G06N3/08

Abstract: Present invention is directed to an artificial intelligence-based method and a system, that uses both experimental results data and molecular simulation to predict properties of amorphous solid dispersions such as glass transition temperature, dissolution profile, and/or physical stability. The method and system of the present invention enable rational design of amorphous solid dispersions for poorly water-soluble drugs and significantly reduce the time and resource required for amorphous solid dispersions formulation development.

公开(公告)号：US20230263712A1

公开(公告)日：2023-08-24

申请号：US18012373

申请日：2021-06-28

Applicant: ISP INVESTMENTS LLC

Inventor： Hani M. FARES ,  Yevgeniy TUROVSKIY ,  Solomon Howard JACOBSON ,  Philip John OTHS ,  Petros GEBRESELASSIE ,  Joseph TORELLA ,  Karen WINKOWSKI

IPC: A61K8/35 ,  A61Q11/00

CPC classification number: A61K8/35 ,  A61Q11/00 ,  A61K2800/524 ,  A61K2800/92 ,  A61K2800/74

Abstract: An oral care antimicrobial composition comprises about 0.1 to about 99.9 wt. % of at least one compound having the structure of




Also disclosed is a process for preparing the composition and methods of use thereof.

公开(公告)号：US20230240953A1

公开(公告)日：2023-08-03

申请号：US18011903

申请日：2021-06-28

Applicant: ISP INVESTMENTS LLC

Inventor： Solomon Howard JACOBSON ,  Yevgenly TUROVSKIY ,  Joseph TORELLA ,  Karen WINKOWSKI

IPC: A61K8/35

CPC classification number: A61K8/35 ,  A61K2800/74 ,  A61K2800/524

Abstract: The present application provides an antimicrobial composition comprising: (a) about 0.01 to about 99.9 wt. % of at least one compound having a structure of formula (I) or formula (II):




wherein R1 is hydrogen, alkyl, alkoxy or hydroxyl; R2 is hydrogen, alkyl or alkoxy; and (b) about 0.1 to about 95% wt. % of one or more antimicrobial compounds not being compounds of formula (I) and formula (II). Also disclosed is a process for preparing the compositions and method of use thereof.