公开(公告)号：US11833218B2

公开(公告)日：2023-12-05

申请号：US16749832

申请日：2020-01-22

Applicant: Indiana University Research and Technology Corporation

Inventor： Yan Yu

IPC: A61K38/00 ,  A61B5/16 ,  A61K45/00 ,  A61K47/68 ,  C07K16/40 ,  C07K16/28 ,  A61B5/00 ,  B82Y5/00

CPC classification number: A61K47/6811 ,  A61B5/165 ,  A61B5/167 ,  A61B5/4076 ,  A61K47/6898 ,  C07K16/2809 ,  C07K16/40 ,  A61B5/00 ,  B82Y5/00

Abstract: Described herein are biomimetic Janus particles useful as artificial antigen presenting cells capable of activating T cells in vitro. “Bull's eye” ligand patterns mimicking either the native or reverse organization of the T cell immunological synapse are provided on the surface of nano- or micro-sized particles. Methods for activating T cells in vitro using biomimetic Janus particles described herein are also provided. T cells activated by the biomimetic Janus particles can be used in adoptive immunotherapies for treating cancer, tolerance induction in autoimmune disease, autologous immune enhancement therapy, and viral infection immunotherapy. Also described herein are methods for producing a biomimetic Janus particle.

公开(公告)号：US20250152733A1

公开(公告)日：2025-05-15

申请号：US18837694

申请日：2023-02-08

Applicant: Indiana University Research and Technology Corporation

Inventor： Yan Yu ,  Jared T. Wiemann ,  Swagata Bhattacharyya

IPC: A61K47/69 ,  A61P31/04

Abstract: “Two-faced” amphiphilic Janus nanoparticles that have different surface chemistries on two hemispheres. One hemisphere of the Janus nanoparticles is functionalized with a hydrophobic moiety. The other hemisphere of the nanoparticles is functionalized with either a cationic antibiotic or cationic polymer. Janus nanoparticles effectively inhibit the growth of both Gram-negative and Gram-positive bacteria at picomolar concentrations and may be used as a broad-spectrum antibiotic on surfaces or to treat bacterial infections in patients.

公开(公告)号：US20200230255A1

公开(公告)日：2020-07-23

申请号：US16749832

申请日：2020-01-22

Applicant: Indiana University Research and Technology Corporation

Inventor： Yan Yu

IPC: A61K47/68 ,  C07K16/28 ,  C07K16/40 ,  A61B5/00 ,  A61B5/16

Abstract: Described herein are biomimetic Janus particles useful as artificial antigen presenting cells capable of activating T cells in vitro. “Bull's eye” ligand patterns mimicking either the native or reverse organization of the T cell immunological synapse are provided on the surface of nano- or micro-sized particles. Methods for activating T cells in vitro using biomimetic Janus particles described herein are also provided. T cells activated by the biomimetic Janus particles can be used in adoptive immunotherapies for treating cancer, tolerance induction in autoimmune disease, autologous immune enhancement therapy, and viral infection immunotherapy. Also described herein are methods for producing a biomimetic Janus particle.

公开(公告)号：US10556016B2

公开(公告)日：2020-02-11

申请号：US15513143

申请日：2015-09-23

Applicant: Indiana University Research and Technology Corporation

Inventor： Yan Yu

IPC: A61K38/00 ,  A61K45/00 ,  A61K47/68 ,  A61B5/16 ,  A61B5/00

Abstract: Described herein are biomimetic Janus particles useful as artificial antigen presenting cells capable of activating T cells in vitro. “Bull's eye” ligand patterns mimicking either the native or reverse organization of the T cell immunological synapse are provided on the surface of nano- or micro-sized particles. Methods for activating T cells in vitro using biomimetic Janus particles described herein are also provided. T cells activated by the biomimetic Janus particles can be used in adoptive immunotherapies for treating cancer, tolerance induction in autoimmune disease, autologous immune enhancement therapy, and viral infection immunotherapy. Also described herein are methods for producing a biomimetic Janus particle.

公开(公告)号：US20170304462A1

公开(公告)日：2017-10-26

申请号：US15513143

申请日：2015-09-23

Applicant: Indiana University Research and Technology Corporation

Inventor： Yan Yu

IPC: A61K47/68 ,  A61B5/16 ,  A61B5/00

CPC classification number: A61K47/6811 ,  A61B5/00 ,  A61B5/165 ,  A61B5/167 ,  A61B5/4076 ,  A61K47/6898 ,  B82Y5/00 ,  C07K16/2809 ,  C07K16/40

Abstract: Described herein are biomimetic Janus particles useful as artificial antigen presenting cells capable of activating T cells in vitro. “Bull's eye” ligand patterns mimicking either the native or reverse organization of the T cell immunological synapse are provided on the surface of nano- or micro-sized particles. Methods for activating T cells in vitro using biomimetic Janus particles described herein are also provided. T cells activated by the biomimetic Janus particles can be used in adoptive immunotherapies for treating cancer, tolerance induction in autoimmune disease, autologous immune enhancement therapy, and viral infection immunotherapy. Also described herein are methods for producing a biomimetic Janus particle.