公开(公告)号：US20240076697A1

公开(公告)日：2024-03-07

申请号：US18240550

申请日：2023-08-31

Applicant: Inscripta, Inc.

Inventor： Karl GERHARDT ,  Charles JOHNSON ,  Martha BRAUN

IPC: C12N15/90 ,  C12N1/20 ,  C12N1/38 ,  C12N9/22 ,  C12N15/11 ,  C12N15/70

CPC classification number: C12N15/902 ,  C12N1/20 ,  C12N1/38 ,  C12N9/22 ,  C12N15/11 ,  C12N15/70 ,  C12N2310/20 ,  C12N2800/101 ,  C12N2800/80 ,  C12N2830/002

Abstract: The present disclosure provides compositions of matter, methods, systems, and instruments for improved nucleic acid-guided nuclease editing in live cells, wherein the live cells are shifted into a growth-arrested state for editing.

公开(公告)号：US20230183683A1

公开(公告)日：2023-06-15

申请号：US18166868

申请日：2023-02-09

Applicant: Inscripta, Inc.

Inventor： Tian TIAN ,  Eileen SPINDLER ,  Clint DAVIS ,  Charles JOHNSON ,  Andrew GARST

IPC: C12N15/10 ,  C12N15/11 ,  C12N9/22 ,  C12N15/63 ,  C12N15/70

CPC classification number: C12N15/1082 ,  C12N15/111 ,  C12N9/22 ,  C12N15/63 ,  C12N15/70 ,  C12N2310/20 ,  C12N2820/002

Abstract: The present disclosure provides compositions of matter, methods, modules and automated multi-module instrumentation for performing editing of live cells followed by curing of editing and engine vectors from prior rounds of editing, followed by curing of the curing vector.