公开(公告)号：US20210254105A1

公开(公告)日：2021-08-19

申请号：US17173137

申请日：2021-02-10

Applicant: Inscripta, Inc.

Inventor： Matthew Estes ,  Chad Sanada ,  Miles Gander ,  Eileen Spindler

IPC: C12N15/90

Abstract: The present disclosure provides compositions and methods to increase the percentage of edited yeast cells in a cell population when employing nucleic-acid guided editing, and automated multi-module instruments for performing these methods.

公开(公告)号：US20200230556A1

公开(公告)日：2020-07-23

申请号：US16844330

申请日：2020-04-09

Applicant: Inscripta, Inc.

Inventor： Phillip Belgrader ,  Don Masquelier ,  Matthew Estes ,  Bruce Chabansky ,  Andrew Garst ,  Richard Fox ,  Jorge Bernate

IPC: B01D63/08

Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.

公开(公告)号：US10532324B1

公开(公告)日：2020-01-14

申请号：US16540606

申请日：2019-08-14

Applicant: Inscripta, Inc.

Inventor： Don Masquelier ,  Phillip Belgrader ,  Andrew Garst ,  Richard Fox ,  Matthew Estes ,  Bruce Chabansky

IPC: B01D63/08 ,  B01D25/00

Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.

公开(公告)号：US20200346168A1

公开(公告)日：2020-11-05

申请号：US16928312

申请日：2020-07-14

Applicant: Inscripta, Inc.

Inventor： Phillip Belgrader ,  Don Masquelier ,  Matthew Estes ,  Bruce Chabansky ,  Andrew Garst ,  Richard Fox ,  Jorge Bernate

IPC: B01D63/08

Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.

公开(公告)号：US20210031144A1

公开(公告)日：2021-02-04

申请号：US17073300

申请日：2020-10-17

Applicant: Inscripta, Inc.

Inventor： Phillip Belgrader ,  Don Masquelier ,  Matthew Estes ,  Bruce Chabansky ,  Andrew Garst ,  Richard Fox ,  Jorge Bernate

IPC: B01D63/08

Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.

公开(公告)号：US20200078738A1

公开(公告)日：2020-03-12

申请号：US16687640

申请日：2019-11-18

Applicant: Inscripta, Inc.

Inventor： Don Masquelier ,  Phillip Belgrader ,  Andrew Garst ,  Richard Fox ,  Matthew Estes ,  Bruce Chabansky

IPC: B01D63/08

Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.

公开(公告)号：US10752874B2

公开(公告)日：2020-08-25

申请号：US16686066

申请日：2019-11-15

Applicant: Inscripta, Inc.

Inventor： Charles Johnson ,  Miles Gander ,  Don Masquelier ,  Phillip Belgrader ,  Andrew Garst ,  Matthew Estes ,  Bruce Chabansky ,  Jorge Bernate

IPC: C12M1/00 ,  C12M1/26 ,  C12M3/00 ,  C12N15/87 ,  B01D25/00 ,  B01D63/08 ,  B01D29/05 ,  B01D71/02 ,  B01D69/06

Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.

公开(公告)号：US10744463B2

公开(公告)日：2020-08-18

申请号：US16844330

申请日：2020-04-09

Applicant: Inscripta, Inc.

Inventor： Phillip Belgrader ,  Don Masquelier ,  Matthew Estes ,  Bruce Chabansky ,  Andrew Garst ,  Richard Fox ,  Jorge Bernate

IPC: B01D63/08 ,  B01D25/00

Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.

公开(公告)号：US20200071657A1

公开(公告)日：2020-03-05

申请号：US16686066

申请日：2019-11-15

Applicant: Inscripta, Inc.

Inventor： Charles Johnson ,  Miles Gander ,  Don Masquelier ,  Phillip Belgrader ,  Andrew Garst ,  Matthew Estes ,  Bruce Chabansky

IPC: C12M1/00 ,  C12N15/87 ,  C12M3/00 ,  C12M1/26

Abstract: The present disclosure provides instruments, modules and methods for improved detection of edited cells following nucleic acid-guided nuclease genome editing. The disclosure provides improved automated instruments that perform methods—including high throughput methods—for screening cells that have been subjected to editing and identifying cells that have been properly edited.