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公开(公告)号：US11447574B2
公开(公告)日：2022-09-20
申请号：US16564148
申请日：2019-09-09
Applicant: JOINT STOCK COMPANY “BIOCAD”
Inventor： Andrey Borisovich Ulitin , Stanislav Rudolfovich Evdokimov , Valeriy Vladimirovich Soloviev , Yulia Sergeevna Chernykh , Olga Vladimirovna Goncharova , Dmitriy Valerievich Korzhavin , Tatyana Veniaminovna Chernovskaya , Timofey Aleksandrovich Nemankin , Roman Alexeevich Ivanov , Dmitriy Valentinovich Morozov , Victoria Mikhailovna Ekimova , Ekaterina Vladimirovna Sofronova , Yakov Yurevich Ustyugov
IPC: A61K39/395 , C07K16/46 , A61K45/06 , C07K16/24
Abstract: The monoclonal IgG-type antibodies were suggested comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain VL. Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.
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公开(公告)号：US10442857B2
公开(公告)日：2019-10-15
申请号：US15254190
申请日：2016-09-01
Applicant: CLOSED JOINT STOCK COMPANY “BIOCAD”
Inventor： Andrey Borisovich Ulitin , Stanislav Rudolfovich Evdokimov , Valeriy Vladimirovich Soloviev , Yulia Sergeevna Chernyh , Olga Vladimirovna Goncharova , Dmitriy Valerievich Korzhavin , Tatyana Veniaminovna Chernovskaya , Roman Alexeevich Ivanov , Dmitriy Valentinovich Morozov
IPC: A61K39/395 , C07K16/24 , A61K45/06 , A61K39/00
Abstract: The present invention relates to the field of medicine, and specifically to the field of monoclonal antibodies against human IL-17. More specifically, the invention relates to monoclonal antibodies/antagonists of IL-17A, which bind with high affinity to an IL-17 epitope, wherein the antibodies contain amino acid substitutions in hypervariable regions of heavy and light chains. The antibodies according to this invention can be chimeric, humanized or human antibodies or antigen-binding fragments thereof, and can be used as a medicinal agent for treating autoimmune and inflammatory disorders and disorders of cell proliferation and development. The invention also relates to methods for producing said antibodies.
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公开(公告)号：US10442869B2
公开(公告)日：2019-10-15
申请号：US15254225
申请日：2016-09-01
Applicant: CLOSED JOINT STOCK COMPANY “BIOCAD”
Inventor： Andrey Borisovich Ulitin , Stanislav Rudolfovich Evdokimov , Valeriy Vladimirovich Soloviev , Yulia Sergeevna Chernyh , Olga Vladimirovna Goncharova , Dmitriy Valerievich Korzhavin , Tatyana Veniaminovna Chernovskaya , Timofey Aleksandrovich Nemankin , Roman Alexeevich Ivanov , Dmitriy Valentinovich Morozov , Victoria Mikhailovna Ekimova , Ekaterina Vladimirovna Sofronova , Yakov Yurevich Ustyugov
IPC: A61K39/395 , C07K16/46 , A61K45/06 , C07K16/24
Abstract: The monoclonal IgG-type antibodies were suggested comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain VL. Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.
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公开(公告)号：US11136408B2
公开(公告)日：2021-10-05
申请号：US16095800
申请日：2017-07-04
Applicant: JOINT STOCK COMPANY “BIOCAD”
Inventor： Viktoriia Mikhailovna Ekimova , Dmitry Valeryevich Korzhavin , Yulia Sergeevna Chernykh , Timofey Aleksandrovich Nemankin , Valery Vladimirovich Solovyev , Anna Konstantinovna Vladimirova , Irina Andreevna Bulankina , Sergei Vasilyevich Diduk , Olga Vladimirovna Goncharova , Anna Vladimirovna Eroshova , Iakov Lurevich Ustiugov , Marina Vladimirovna Artiukhova , Andrei Borisovich Ulitin , Roman Alekseevich Ivanov , Dmitry Valentinovich Morozov
Abstract: The present invention relates to biotechnology and comprises isolated monoclonal antibodies, in particular human monoclonal antibodies, which specifically bind to PD-1 with high affinity. The antibodies according to the invention may be chimeric, humanized or human antibodies, or antigen-binding fragments thereof, and may be used as a medicinal agent in oncology and immuno-oncology, for treating diseases associated with various cell proliferation or development disorders. The invention also relates to methods for producing said antibodies and a method for treating human diseases using said antibodies.
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