公开(公告)号：US20130158034A1

公开(公告)日：2013-06-20

申请号：US13529880

申请日：2012-06-21

申请人： James BROWN ,  Jian J. CHEN ,  Vijay Keshav GORE ,  Scott HARRIED ,  Daniel B. Horne ,  Matthew R. KALLER ,  Qingyian LIU ,  Holger MONENSCHEIN ,  Thomas T. NGUYEN ,  Nobuko NISHIMURA ,  Wenge ZHONG

发明人： James BROWN ,  Jian J. CHEN ,  Vijay Keshav GORE ,  Scott HARRIED ,  Daniel B. Horne ,  Matthew R. KALLER ,  Qingyian LIU ,  Holger MONENSCHEIN ,  Thomas T. NGUYEN ,  Nobuko NISHIMURA ,  Wenge ZHONG

IPC分类号： C07D401/14 ,  C07D213/40 ,  C07D409/12 ,  C07D413/12 ,  C07D401/12 ,  C07D213/75 ,  C07D405/12

CPC分类号： C07D213/53 ,  C07C275/30 ,  C07D213/40 ,  C07D213/75 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

摘要： Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

公开(公告)号：US20110229067A1

公开(公告)日：2011-09-22

申请号：US12728800

申请日：2010-03-22

申请人： James BROWN ,  Charles SCHWAB ,  Joseph GRIFFIN ,  Seth CLAUS

发明人： James BROWN ,  Charles SCHWAB ,  Joseph GRIFFIN ,  Seth CLAUS

IPC分类号： F16C33/48 ,  F16C33/46

CPC分类号： F16C33/546 ,  F16C19/26 ,  F16C19/30 ,  F16C33/4682

摘要： The bearing cage with high speed features has a pocket with a first flange and a second flange which defines the outer boundaries of the pocket. The first flange and the second flange each have a plurality of inwardly directed protrusions facing each other. The protrusions are contactable at each end of rollers, which are arranged in the bearing cage. The protrusions can be dome shaped, creating a small area of contact between the rollers and protrusions. The point of contact between the rollers and the protrusions is at the center of the rollers, which reduces the relative speed between the ends of the pockets and the rollers.

摘要翻译： 具有高速特征的轴承保持架具有带有第一凸缘和第二凸缘的凹槽，该凸缘限定凹槽的外边界。 第一凸缘和第二凸缘各自具有面向彼此的多个向内指向的突出部。 这些突起可在滚子的每个端部接触，辊子布置在轴承座中。 突起可以是圆顶形，在辊和突起之间产生小的接触面积。 辊和突起之间的接触点位于辊的中心，这降低了袋和辊的端部之间的相对速度。

公开(公告)号：US20110249929A1

公开(公告)日：2011-10-13

申请号：US12758444

申请日：2010-04-12

申请人： James BROWN ,  Seth CLAUS ,  Michael TURNER

发明人： James BROWN ,  Seth CLAUS ,  Michael TURNER

IPC分类号： F16C33/46

CPC分类号： F16C33/546 ,  F16C19/26

摘要： The bearing cage has a first flange, a second flange, and a plurality of cage bars extending between the first flange and the second flange so as to form and define outer boundaries for a plurality of pockets. The first flange and the second flange are each bent inward toward the pocket and then extend parallel in a vertical direction, forming a contact surfaces. The contact surfaces are in contact at each end of the rollers arranged in the pocket. The contact surfaces of the bearing cage present a large contact area between the ends of the rollers and the ends of the pockets where there is a lubricant film. Also, the surface of the contact surfaces is smooth.

摘要翻译： 轴承保持架具有第一凸缘，第二凸缘和在第一凸缘和第二凸缘之间延伸的多个保持架，以便形成和限定多个凹穴的外边界。 第一凸缘和第二凸缘均朝向凹部向内弯曲，然后在垂直方向上平行延伸，形成接触表面。 接触表面在布置在口袋中的辊的每个端部处接触。 轴承座的接触表面在辊的端部和凹穴的端部之间具有大的接触面积，其中存在润滑剂膜。 此外，接触表面的表面是光滑的。

公开(公告)号：US20110049304A1

公开(公告)日：2011-03-03

申请号：US12855793

申请日：2010-08-13

申请人： James BROWN

发明人： James BROWN

IPC分类号： B64C21/04

CPC分类号： B64C21/04 ,  Y02T50/166

摘要： An aerofoil defining geometric upper and lower surfaces which together form a leading edge region and a trailing edge region, and comprising a blowing device having a slot in the lower geometric surface in the leading edge region for injecting fluid into the airflow over the aerofoil, wherein the slot is located forward of the leading edge stagnation point at the critical angle of incidence of the aerofoil, and wherein the blowing device is adapted to inject the fluid forwardly of the slot and substantially parallel to the lower surface. Also, a method of improving the performance of the aerofoil by injecting fluid into the airflow over the aerofoil from the slot. The upper surface of the aerofoil can be kept clean, giving the potential for laminar flow during cruise without significantly compromising the high lift performance of a blown leading edge at high incidence.

摘要翻译： 机翼限定几何上下表面，它们一起形成前缘区域和后缘区域，并且包括吹风装置，该吹风装置在前缘区域中的下几何表面中具有狭槽，用于将流体喷射到机翼上的气流中，其中 所述槽位于所述翼缘的临界入射角处的所述前缘停滞点的前方，并且其中所述吹风装置适于将所述流体向前注入并基本上平行于所述下表面。 而且，一种通过将流体从狭槽喷射到机翼上的空气中来提高机翼的性能的方法。 机翼的上表面可以保持清洁，在巡航期间具有层流的潜力，而不会显着损害高发射时吹出的前缘的高提升性能。

公开(公告)号：US20120251219A1

公开(公告)日：2012-10-04

申请号：US13485013

申请日：2012-05-31

申请人： Jack W. KAUFMAN ,  James BROWN

发明人： Jack W. KAUFMAN ,  James BROWN

IPC分类号： A61M35/00

CPC分类号： A61M35/006 ,  A61M35/003 ,  A61M2210/04 ,  B43M11/06

摘要： A hand-held dispensing applicator comprising a source of fluid, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region therebetween. Preferably, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region. More preferably, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member. Adaptive embodiments allow the generation of designs applicable to a particular medical purpose.

摘要翻译： 一种手持式分配器，其包括流体源，连接到流体源的易碎施用器尖端以及附接到易碎施用器尖端的吸收构件。 当易碎的施用器尖端破裂时，流体从源流向吸收构件，由此将流体施加并扩散在表面上。 优选地，易碎施用器尖端包括永久地连接到流体源的支撑元件，从支撑元件向外延伸的相对刚性的舌元件以及它们之间的易碎区域。 优选地，舌元件包括用于加强舌元件以防止易碎区域的无意破坏的肋。 更优选地，施用器末端包括设置在易碎区域周围的半透性或不可渗透的盖，以控制吸收构件中的流体分散体的速度和方向。 自适应实施例允许生成适用于特定医疗目的的设计。

公开(公告)号：US20130336705A1

公开(公告)日：2013-12-19

申请号：US13971425

申请日：2013-08-20

申请人： Jack W. KAUFMAN ,  James BROWN

发明人： Jack W. KAUFMAN ,  James BROWN

IPC分类号： A61F13/40

CPC分类号： A61M35/006 ,  A61M35/003 ,  A61M2210/04 ,  B43M11/06

摘要： A hand-held dispensing applicator comprising a fluid source, a frangible applicator tip attached to the fluid source, and an absorbent member attached to the frangible applicator tip is provided. When the frangible applicator tip is broken, fluid flows from the source to the absorbent member, whereby the fluid is applied and spread on a surface. Preferably, the frangible applicator tip comprises a support element permanently connected to the fluid source, a relatively rigid tongue element extending outwardly of the support element, and a frangible region there between. Preferably, the tongue element comprises ribs for reinforcing the tongue element to resist unintentional breaking of the frangible region. More preferably, the applicator tip comprises a semi-permeable or non-permeable cover disposed around the frangible region to control the speed and direction of the dispersion of the fluid in the absorbent member.

摘要翻译： 提供了包括流体源，连接到流体源的易碎施用器尖端和附接到易碎施用器尖端的吸收构件的手持分配施加器。 当易碎的施用器尖端破裂时，流体从源流向吸收构件，由此将流体施加并扩散在表面上。 优选地，易碎的施用器尖端包括永久地连接到流体源的支撑元件，从支撑元件向外延伸的相对刚性的舌元件以及其间的易碎区域。 优选地，舌元件包括用于加强舌元件以防止易碎区域的无意破坏的肋。 更优选地，施用器末端包括设置在易碎区域周围的半透性或不可渗透的盖，以控制吸收构件中的流体分散体的速度和方向。

公开(公告)号：US20120104180A1

公开(公告)日：2012-05-03

申请号：US13279642

申请日：2011-10-24

申请人： James BROWN ,  Edmund KAY

发明人： James BROWN ,  Edmund KAY

IPC分类号： B64C3/50 ,  B64D45/00

CPC分类号： B64C9/24 ,  B64C2009/143 ,  Y02T50/44

摘要： A Krueger, or leading edge flap, deployable from a lower aerodynamic surface of an aircraft main wing element so as to form a slot between the Krueger and the main wing element when deployed, the deployed Krueger having a leading edge, a trailing edge and upper and lower aerodynamic surfaces extending between the leading edge and the trailing edge, and a flow deflector which provides an effectively divergent flap profile thickness in the downstream direction at or adjacent the Krueger trailing edge so as to direct airflow away from the lower aerodynamic surface of the deployed Krueger towards an upper aerodynamic surface of the main wing element. Also, aircraft wing assembly including a main wing element and the Krueger.

摘要翻译： Krueger或前缘翼片可从飞机主翼元件的下部空气动力学表面展开，以便在部署时在Krueger和主翼元件之间形成槽，部署的Krueger具有前缘，后缘和上部 以及在前缘和后缘之间延伸的下部空气动力学表面，以及导流器，其在Krueger后缘处或邻近Krueger后缘处沿下游方向提供有效发散的翼片轮廓厚度，以便将气流从空气动力学表面 将Krueger部署到主翼元件的上部空气动力学表面。 此外，飞机机翼组件包括主翼元件和Krueger。

公开(公告)号：US20110182542A1

公开(公告)日：2011-07-28

申请号：US12695568

申请日：2010-01-28

申请人： James BROWN ,  Eric CLARK ,  Joseph GRIFFIN

发明人： James BROWN ,  Eric CLARK ,  Joseph GRIFFIN

IPC分类号： F16C33/34

CPC分类号： F16C33/34 ,  F16C19/30 ,  F16C19/46 ,  F16C27/04

摘要： A thrust needle bearing with an isolating layer has a cage with rollers, washers on which the rollers run, at least one of the washers is attached to the cage, backup surfaces fixed external to each of the washers and an isolating layer attached to at least one of the washers, which is interposed between the at least one of the washers and at least one of the backup surfaces of the bearing. The isolating layer is a layer of vibration-attenuating material. Alternatively, the isolating layer is a layer of material which has properties that prevent creep or sliding wear for at least one of the backup surfaces. The isolating layer is attached to the washers by bonding, use of adhesives or mechanical means.

摘要翻译： 具有隔离层的推力滚针轴承具有带滚子的保持架，滚子运行在其上的垫圈，至少一个垫圈连接到保持架，固定在每个垫圈外部的支撑表面和至少连接到隔离层的隔离层 其中一个垫圈介于至少一个垫圈和轴承的至少一个支承表面之间。 隔离层是一层振动衰减材料。 或者，隔离层是具有防止至少一个支撑表面的蠕变或滑动磨损的特性的材料层。 隔离层通过粘结，使用粘合剂或机械方式附着在垫圈上。