公开(公告)号：US09375495B2

公开(公告)日：2016-06-28

申请号：US12527482

申请日：2008-04-11

申请人： Jinwoo Cheon ,  Young-wook Jun ,  Jung-tak Jang

发明人： Jinwoo Cheon ,  Young-wook Jun ,  Jung-tak Jang

IPC分类号： A61K49/06 ,  A61K49/18 ,  C01G49/00 ,  H01F1/00 ,  B82Y5/00 ,  B82Y25/00

CPC分类号： A61K49/1875 ,  A61K49/1836 ,  A61K49/1863 ,  A61K49/1866 ,  A61K49/1869 ,  B82Y5/00 ,  B82Y25/00 ,  C01G49/0063 ,  C01G49/009 ,  C01P2002/72 ,  C01P2002/85 ,  C01P2004/04 ,  C01P2006/42 ,  H01F1/0054 ,  Y10S977/773 ,  Y10S977/93

摘要： The present invention relates to an MRI contrast agent that includes zinc-containing water-soluble metal oxide nanoparticles and has an improved contrast effect. The zinc-containing water-soluble metal oxide nanoparticles are characterized by addition of zinc to a matrix comprising the metal oxide nanoparticles or by substitution of metal in the matrix, resulting in the improved contrast effect of MRI. In addition, the zinc-containing metal oxide nanoparticles of the present invention include the MRI contrast agent t having hybrid structures of “zinc-containing metal oxide nanoparticle—biologically/chemically active material” in which the nanoparticle is conjugated with a bioactive material such as proteins, antibodies, and chemical materials.

摘要翻译： 本发明涉及包含含锌水溶性金属氧化物纳米粒子并具有改善的对比效果的MRI造影剂。 含锌水溶性金属氧化物纳米颗粒的特征在于将锌添加到包含金属氧化物纳米颗粒的基质中或通过置换基质中的金属，导致MRI的对比度改善。 此外，本发明的含锌金属氧化物纳米颗粒包括具有“含锌金属氧化物纳米颗粒 - 生物/化学活性材料”的混合结构的MRI造影剂t，其中纳米颗粒与生物活性材料如 蛋白质，抗体和化学物质。

公开(公告)号：US20100143263A1

公开(公告)日：2010-06-10

申请号：US12527482

申请日：2008-04-11

申请人： Jinwoo Cheon ,  Young-wook Jun ,  Jung-tak Jang

发明人： Jinwoo Cheon ,  Young-wook Jun ,  Jung-tak Jang

IPC分类号： A61K49/06 ,  C01G9/02

CPC分类号： A61K49/1875 ,  A61K49/1836 ,  A61K49/1863 ,  A61K49/1866 ,  A61K49/1869 ,  B82Y5/00 ,  B82Y25/00 ,  C01G49/0063 ,  C01G49/009 ,  C01P2002/72 ,  C01P2002/85 ,  C01P2004/04 ,  C01P2006/42 ,  H01F1/0054 ,  Y10S977/773 ,  Y10S977/93

摘要： The present invention relates to an MRI contrast agent that includes zinc-containing water-soluble metal oxide nanoparticles and has an improved contrast effect. The zinc-containing water-soluble metal oxide nanoparticles are characterized by addition of zinc to a matrix comprising the metal oxide nanoparticles or by substitution of metal in the matrix, resulting in the improved contrast effect of MRI. In addition, the zinc-containing metal oxide nanoparticles of the present invention include the MRI contrast agent t having hybrid structures of “zinc-containing metal oxide nanoparticle—biologically/chemically active material” in which the nanoparticle is conjugated with a bioactive material such as proteins, antibodies, and chemical materials.

摘要翻译： 本发明涉及包含含锌水溶性金属氧化物纳米粒子并具有改善的对比效果的MRI造影剂。 含锌水溶性金属氧化物纳米颗粒的特征在于将锌添加到包含金属氧化物纳米颗粒的基质中或通过置换基质中的金属，导致MRI的对比度改善。 此外，本发明的含锌金属氧化物纳米颗粒包括具有“含锌金属氧化物纳米颗粒 - 生物/化学活性材料”的混合结构的MRI造影剂t，其中纳米颗粒与生物活性材料如 蛋白质，抗体和化学物质。