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    Magnetic Probe Apparatus
    2.
    发明公开
    Magnetic Probe Apparatus 审中-公开

    公开(公告)号：US20230176152A1

    公开(公告)日：2023-06-08

    申请号：US18103828

    申请日：2023-01-31

    申请人： ENDOMAGNETICS LIMITED

    发明人： Simon Richard Hattersley

    IPC分类号： G01R33/12 ,  A61B5/05 ,  A61B5/06 ,  A61B5/00 ,  A61K49/18 ,  B82Y5/00

    CPC分类号： G01R33/1269 ,  A61B5/05 ,  A61B5/065 ,  A61B5/415 ,  A61B5/4312 ,  A61K49/1863 ,  B82Y5/00 ,  A61B5/418 ,  A61B2562/12 ,  A61B2017/00876

    摘要： A system and method for locating magnetic material. In one embodiment the system includes a magnetic probe; a power module in electrical communication with the magnetic probe to supply current to the magnetic probe; a sense module in electrical communication with the magnetic probe to receive signals from the magnetic probe; and a computer in electrical communication with the power module and the sense module. The computer generates a waveform that controls the supply of current from the power module and receives a signal from the sense module that indicates the presence of magnetic material. The magnetic probe is constructed from a material having a coefficient of thermal expansion of substantially 10−6/° C. or less and a Young's modulus of substantially 50 GPa or greater. In one embodiment magnetic nanoparticles are injected into a breast and the lymph nodes collecting the particles are detected with the probe and deemed sentinel nodes.

    Methods and compositions related to clot binding compounds
    7.
    发明授权
    Methods and compositions related to clot binding compounds 有权
    与凝块结合化合物相关的方法和组合物

    公开(公告)号：US09101671B2

    公开(公告)日：2015-08-11

    申请号：US11967509

    申请日：2007-12-31

    申请人： Erkki Ruoslahti ,  Dmitri Simberg

    发明人： Erkki Ruoslahti ,  Dmitri Simberg

    IPC分类号： A61K39/00 ,  A61K47/48 ,  A61K49/18 ,  B82Y5/00

    CPC分类号： A61K47/48861 ,  A61K47/48238 ,  A61K47/48815 ,  A61K47/48884 ,  A61K47/62 ,  A61K47/6911 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/1863 ,  A61K49/1866 ,  B82Y5/00 ,  Y10T428/2984

    摘要： Disclosed are compositions and methods related to clot binding compounds. For example, disclosed are conjugates comprising a surface molecule and a plurality of clot binding compounds. The clot binding compounds can selectively bind to clotted plasma protein. The conjugate can, for example, cause clotting and amplify the accumulation of the conjugate in tumors. In one example, the conjugate can comprise a sufficient number and composition of clot binding compounds such that the conjugate causes clotting and amplifies the accumulation of the conjugate in tumors. The disclosed targeting is useful for treatment of cancer and other diseases and disorders.

    摘要翻译： 公开了与凝块结合化合物相关的组合物和方法。 例如，公开了包含表面分子和多个凝块结合化合物的缀合物。 凝块结合化合物可以选择性地结合凝血的血浆蛋白。 结合物可以例如引起凝血并且扩增缀合物在肿瘤中的积累。 在一个实例中，缀合物可以包含足够数量和组合物的凝块结合化合物，使得缀合物引起凝血并扩增缀合物在肿瘤中的积累。 所公开的靶向对于治疗癌症和其它疾病和病症是有用的。

    PLASMONIC STABLE FLUORESCENCE SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES AND A METHOD OF SYNTHESIZING THE SAME
    9.
    发明申请
    PLASMONIC STABLE FLUORESCENCE SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES AND A METHOD OF SYNTHESIZING THE SAME 审中-公开
    等离子体稳定荧光超级磁铁氧化物纳米颗粒及其合成方法

    公开(公告)号：US20140234226A1

    公开(公告)日：2014-08-21

    申请号：US14270879

    申请日：2014-05-06

    申请人： Morteza Mahmoudi ,  Mohammad Ali Shokrgozar

    发明人： Morteza Mahmoudi ,  Mohammad Ali Shokrgozar

    IPC分类号： A61K49/18

    CPC分类号： A61K49/1863

    摘要： The various embodiments herein provide for the engineered multimodal super paramagnetic iron oxide nanoparticles (SPIONs) with a fluorescent dye. The SPIONs comprise fluorescent polymer dye arranged in a gap between a SPION core and a gold shell. The SPIONS are provided with a gold coating. The gap is made up of a polymeric molecule such as 6-arm anthracene terminated. The core of the nanoparticle is made up of a magnetic metal oxide. The method for synthesizing SPIONs involves preparing carboxyl-dextran complex and the SPIONS. The SPIONs are coated with carboxyl-dextran complex. The coated SPIONs coated are subjected to fluorescent polymer and gold nano shell coating. The prepared SPIONs are characterized by light scattering measurement and magnetization measurements.

    摘要翻译： 本文的各种实施方案提供具有荧光染料的工程多模超顺磁性氧化铁纳米颗粒（SPION）。 SPION包括布置在SPION芯和金壳之间的间隙中的荧光聚合物染料。 SPIONS配有镀金涂层。 间隙由诸如6-臂蒽末端的聚合物分子组成。 纳米颗粒的核心由磁性金属氧化物组成。 合成SPION的方法包括制备羧基葡聚糖复合物和SPIONS。 SPIONs涂有羧基葡聚糖复合物。 涂覆的涂覆的SPIONs经受荧光聚合物和金纳米壳涂层。 制备的SPION的特征在于光散射测量和磁化测量。

    HIGH-SENSITIVITY MAGNETIC RESONANCE IMAGING NANO-CONTRAST AGENT BASED ON AN ANIONIC POLYMER AND CATIONIC POLYMER ION COMPLEX, AND A PRODUCTION METHOD THEREFOR
    10.
    发明申请
    HIGH-SENSITIVITY MAGNETIC RESONANCE IMAGING NANO-CONTRAST AGENT BASED ON AN ANIONIC POLYMER AND CATIONIC POLYMER ION COMPLEX, AND A PRODUCTION METHOD THEREFOR 有权
    基于阴离子聚合物和阳离子聚合物复合物的高灵敏度磁共振成像纳米对比剂及其制备方法

    公开(公告)号：US20140170077A1

    公开(公告)日：2014-06-19

    申请号：US14110138

    申请日：2011-04-07

    申请人： Moon-Hee Sung ,  Yong Taik Lim ,  Young-Woock Noh ,  Il Han Lee ,  Hyun Min Kim

    发明人： Moon-Hee Sung ,  Yong Taik Lim ,  Young-Woock Noh ,  Il Han Lee ,  Hyun Min Kim

    IPC分类号： A61K49/12

    CPC分类号： A61K49/126 ,  A61K49/1863 ,  A61K49/1872

    摘要： The present invention relates to a nano-composite containing anionic and cationic polymers and a method for preparing thereof, and more particularly to a poly-gamma-glutamic acid (γ-PGA)/chitosan/manganese iron oxide nanoparticle composite prepared by encapsulating iron oxide-based nanoparticles in a γ-PGA/chitosan polymer composite using the ionic self-assembly properties of poly-gamma-glutamic acid (γ-PGA) and chitosan, which are biocompatible polymer materials, and to a method for preparing thereof.The present invention provides a magnetic resonance imaging nano-contrast agent based on a nanoparticle composite including iron oxide-based nanoparticles encapsulated in a self-assembled composite of anionic poly-gamma-glutamic acid (γPGA) and cationic chitosan. The iron oxide-based nanoparticles encapsulated in the composite interact with each other to produce a synergistic effect on the amplification of magnetic resonance signals, and thus have an relatively excellent contrast effect compared to when they exist as single particles.

    摘要翻译： 本发明涉及含有阴离子和阳离子聚合物的纳米复合物及其制备方法，更具体地涉及通过包封氧化铁制备的聚-γ-谷氨酸（γ-PGA）/壳聚糖/锰铁氧体纳米颗粒复合材料 基于聚-γ-谷氨酸（γ-PGA）和壳聚糖的离子自组装性质的γ-PGA /壳聚糖复合材料的生物相容性聚合物材料的制备方法。 本发明提供一种基于纳米颗粒复合材料的磁共振成像纳米造影剂，其包括封装在阴离子聚-γ-谷氨酸（γPGA）和阳离子壳聚糖的自组装复合物中的基于氧化铁的纳米颗粒。 封装在复合材料中的基于氧化铁的纳米颗粒彼此相互作用以对磁共振信号的扩增产生协同效应，因此与作为单个颗粒存在时相比具有相对优异的对比效果。