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公开(公告)号:US07687468B2
公开(公告)日:2010-03-30
申请号:US10437621
申请日:2003-05-14
IPC分类号: A01N1/02 , A61K31/7004 , A61K31/122 , A61K31/047 , A61K35/18
CPC分类号: A01N1/02 , A01N1/0226
摘要: D-Ribose, a buffer and an anticoagulant are added to whole blood or packed red cells to extend function in storage beyond 42 days. Methods are disclosed to rejuvenate suboptimally functional red cells. The methods are comprised of incubation of the cells at 37° C. for 10 to 60 minutes in the presence of D-ribose.
摘要翻译: 将D-核糖,缓冲液和抗凝剂加入到全血或包装的红细胞中,以延长储存超过42天的功能。 公开了用于恢复次优功能的红细胞的方法。 所述方法包括在D-核糖存在下在37℃孵育10至60分钟。
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公开(公告)号:US06511964B2
公开(公告)日:2003-01-28
申请号:US09821238
申请日:2001-03-29
IPC分类号: A61K3170
CPC分类号: A61K31/7004
摘要: Persons encountering high altitudes without being acclimatized can prevent or alleviate the symptoms of acute mountain sickness by administration of ribose one to four times a days, beginning immediately on encountering high altitudes and continuing for at least five days.
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公开(公告)号:US4099933A
公开(公告)日:1978-07-11
申请号:US585696
申请日:1975-06-10
申请人: Clarence A. Johnson , John Shen
发明人: Clarence A. Johnson , John Shen
CPC分类号: C10J3/84 , C10J3/503 , C10J3/54 , C10J3/721 , C10J2300/0903 , C10J2300/093 , C10J2300/0956 , C10J2300/0959 , C10J2300/0976 , C10J2300/1807 , C10J2300/1884 , C10J2300/1892 , Y10S48/04
摘要: The gasification of coal to produce a methane-rich product gas is accomplished through the controlled slow heating of particulate coal in a gasifier comprising two or more zones, whereby any significant decrease in the density of the coal particles is minimized and particle swelling and friability are significantly reduced, while the carryover of fines and deposition of tars in the product gas conduit are thereby minimized. The particulate coal heating rate in the gasifier zones is usually between about 10.degree. and 200.degree. F per minute. When the particulate coal is to be fed to the gasifier at elevated temperature, further improvements are achieved with swelling type caking coals through their pretreatment by preheating the coal at a slow rate between 10.degree. and 100.degree. F per minute up to about 800.degree. F in multiple fluidized beds. Any carryover of fines in the product gas stream from the uppermost zone of the gasifier is further reduced by utilizing either a solids separation step or a scrubbing step in the gas stream. The coal particles and/or tars thus recovered are returned to a high temperature zone of the gasifier.
摘要翻译: 通过在包括两个或更多个区域的气化器中对颗粒煤的受控缓慢加热来实现煤的气化以产生富甲烷产物气体,由此煤颗粒密度的任何显着降低最小化并且颗粒膨胀和脆性是 显着地减少了,同时在产品气体导管中的细粒和焦油沉积由此最小化。 气化器区域中的颗粒状煤的加热速度通常为每分钟约10°F至200°F。 当颗粒煤在升高的温度下进入气化器时,通过使用膨胀型结块煤进行预处理,可以进一步改进,通过预热煤,以每分钟10°F至100°F至约800°F 在多个流化床中。 通过利用气流中的固体分离步骤或洗涤步骤,进一步减少来自气化器最上部区域的产物气流中的细粉的残留。 如此回收的煤颗粒和/或焦油返回到气化器的高温区域。
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公开(公告)号:US09572882B2
公开(公告)日:2017-02-21
申请号:US12459112
申请日:2009-06-26
IPC分类号: A61K31/7004 , A61K45/06 , A61K31/195 , A61K31/21 , A61K31/506 , A61K31/519 , A61K31/522 , A61K31/525 , A61K31/70 , A61K33/06
CPC分类号: A61K45/06 , A23L33/10 , A23V2002/00 , A61K31/195 , A61K31/21 , A61K31/506 , A61K31/519 , A61K31/522 , A61K31/525 , A61K31/70 , A61K31/7004 , A61K33/06 , A61K2300/00 , A23V2250/626 , A23V2250/61 , A23V2250/0606 , A23V2250/062 , A23V2250/708 , A23V2250/706 , A23V2250/7052
摘要: The present invention relates to methods for supplementing the diet of subjects suffering from cardiovascular disease. D-Ribose is given long term alone or in combination with vasodilators in order to improve or maintain the diastolic or systolic function of the subjects.
摘要翻译: 本发明涉及补充患有心血管疾病的受试者饮食的方法。 D-核糖单独给予或与血管扩张剂组合,以改善或维持受试者的舒张或收缩功能。
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公开(公告)号:US06218366B1
公开(公告)日:2001-04-17
申请号:US09406266
申请日:1999-09-24
IPC分类号: A61K3170
CPC分类号: A61K33/06 , A61K31/7004 , A61K45/06 , A61K31/195 , A61K2300/00
摘要: The administration of ribose raises the hypoxic threshold of mammals experiencing a hypoxic condition. The presence of an effective amount of ribose in the tissue of a mammal increases the tolerance to hypoxia and decreases the symptoms of hypoxia in mammals experiencing chronic hypoxia due to cardiovascular disease or peripheral vascular disease. Such mammals are additionally benefited by administration of ribose and a vasodilator or an isotropic agent. Mammals experiencing transient hypoxia from high altitude, anesthesia or exercise are also benefited.
摘要翻译: 核糖的施用提高了经历缺氧条件的哺乳动物的缺氧阈值。 在哺乳动物组织中存在有效量的核糖增加对缺氧的耐受性,并降低由于心血管疾病或外周血管疾病而经历慢性缺氧的哺乳动物的缺氧症状。 通过给予核糖和血管扩张剂或各向同性剂,这些哺乳动物另外受益。 从高空,麻醉或运动中经历短暂缺氧的哺乳动物也受益匪浅。
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公开(公告)号:US20100009924A1
公开(公告)日:2010-01-14
申请号:US12459112
申请日:2009-06-26
IPC分类号: A61K31/7004
CPC分类号: A61K45/06 , A23L33/10 , A23V2002/00 , A61K31/195 , A61K31/21 , A61K31/506 , A61K31/519 , A61K31/522 , A61K31/525 , A61K31/70 , A61K31/7004 , A61K33/06 , A61K2300/00 , A23V2250/626 , A23V2250/61 , A23V2250/0606 , A23V2250/062 , A23V2250/708 , A23V2250/706 , A23V2250/7052
摘要: The present invention relates to methods for supplementing the diet of subjects suffering from cardiovascular disease. D-Ribose is given long term alone or in combination with vasodilators in order to improve or maintain the diastolic or systolic function of the subjects.
摘要翻译: 本发明涉及补充患有心血管疾病的受试者饮食的方法。 D-核糖单独给予或与血管扩张剂组合,以改善或维持受试者的舒张或收缩功能。
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公开(公告)号:US06663859B2
公开(公告)日:2003-12-16
申请号:US09756558
申请日:2001-01-08
IPC分类号: A01N6300
CPC分类号: A61K31/7004 , A61K31/70 , A61K2035/124 , A61K2039/515 , C12N2500/34 , Y10S514/885
摘要: D-Ribose and methods for using D-Ribose are provided for enhancing the immune response in mammals. Those with a less than optimal immune response will benefit from oral or parenteral administration of D-Ribose. Methods are also provided for the enhancement of the immune response in isolated leukocytes. Leukocytes are cultured ex vivo in the presence of D-Ribose and transfused into a patient in need of leukocyte augmentation.
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公开(公告)号:US06534480B2
公开(公告)日:2003-03-18
申请号:US09740255
申请日:2000-12-18
申请人: John St. Cyr , Clarence A. Johnson
发明人: John St. Cyr , Clarence A. Johnson
IPC分类号: A61K3170
CPC分类号: A61K31/7004 , A23L33/10 , A23V2002/00 , A23V2250/626 , A23V2250/161 , A23V2250/306 , A23V2250/0606 , A23V2250/0612
摘要: Precursors of adenosine triphosphate are administered orally to increase intracellular ATP concentration as dietary supplements or for treatment of reduced energy availability resulting from strenuous physical activity, illness or trauma. Pentose sugars are administered individually, mixed into dry food or in solution. The preferred pentose is D-ribose, singly or combined with creatine, pyruvate, L-carnitine and/or vasodilating agents. Additionally, magnesium, electrolytes, fatty acids and hexose sugars can be used. The compositions and methods of this invention are especially beneficial to mammals having reduced energy availability or high energy demand.
摘要翻译: 口服三磷酸腺苷的前体以增加细胞内ATP浓度作为膳食补充剂或用于治疗由剧烈的身体活动,疾病或创伤引起的能量可用性降低。 戊糖分别单独施用,混入干燥食物或溶液中。 优选的戊糖是D-核糖,单独或与肌酸,丙酮酸,L-肉毒碱和/或血管舒张剂组合。 另外,可以使用镁,电解质,脂肪酸和己糖。 本发明的组合物和方法对具有降低的能量可用性或高能量需求的哺乳动物特别有益。
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公开(公告)号:US06429198B1
公开(公告)日:2002-08-06
申请号:US09677639
申请日:2000-10-03
IPC分类号: A61K3170
CPC分类号: A61K31/7004 , A61K31/195 , A61K31/21 , A61K31/506 , A61K31/70 , A61K33/06 , A61K45/06 , A61K2300/00
摘要: Pentose is administered to mammals to increase athletic performance and reduce fatigue.
摘要翻译: 向哺乳动物施用戊糖以增加运动性能并减少疲劳
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公开(公告)号:US3985517A
公开(公告)日:1976-10-12
申请号:US606258
申请日:1975-08-20
申请人: Clarence A. Johnson
发明人: Clarence A. Johnson
摘要: Low rank coals such as subbituminous or lignites containing more than about 10 weight percent moisture are dried and passivated against reabsorption of moisture in a fluidized bed by heating the particulate coal with a warm inert gas passing upwardly through the bed and simultaneously coating the warm particulate coal with a heavy liquid hydrocarbon material. Such coating aids in the removal of the moisture and prevents the reabsorption of moisture by the coal and thereby prevents consequential heating and possibly spontaneous ignition of the coal during its subsequent transportation or storage.
摘要翻译: 将低等级煤如含有大于约10重量%水分的次烟或褐煤干燥并钝化,以通过向上通过床加热颗粒煤加热颗粒煤,同时涂覆暖颗粒煤 与重液态碳氢化合物材料。 这种涂层有助于除去水分并防止煤中的水分的再吸收,从而防止随后的运输或储存期间煤的相继加热和可能的自发点燃。
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