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公开(公告)号:US20080207564A1
公开(公告)日:2008-08-28
申请号:US11915305
申请日:2006-03-31
申请人: John L. Wallace , Giuseppe Cirino , Giuseppe Caliendo , Anna Sparatore , Vicenzo Santagada , Stefano Fiorucci
发明人: John L. Wallace , Giuseppe Cirino , Giuseppe Caliendo , Anna Sparatore , Vicenzo Santagada , Stefano Fiorucci
IPC分类号: A61K31/67 , C07D339/04 , A61K31/606 , A61K31/603 , A61P35/00 , A61P1/00 , A61K31/625 , C07F9/6578
CPC分类号: C07C327/42 , C07C323/12 , C07C323/59 , C07C323/60 , C07C327/48 , C07D339/04 , C07F9/6578 , C07F9/6587
摘要: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.
摘要翻译: 本发明提供4-或5-氨基水杨酸的新衍生物和含有这些4-或5-氨基水杨酸衍生物作为活性成分的药物组合物,其可用于治疗肠疾病如炎性肠病(IBD)和 肠易激综合征(IBS)和预防/治疗结肠癌。 更具体地说,这些衍生物包含通过偶氮,酯,酸酐,硫酯或酰胺键与4-或5-氨基水杨酸分子连接的硫化氢释放部分。 此外,本发明提供了制备这些化合物的方法及其用于治疗IBD和IBS以及预防/治疗结肠癌的用途。
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公开(公告)号:US08114857B2
公开(公告)日:2012-02-14
申请号:US12980985
申请日:2010-12-29
申请人: John L. Wallace , Giuseppe Cirino , Giuseppe Caliendo , Anna Sparatore , Vicenzo Santagada , Stefano Fiorucci
发明人: John L. Wallace , Giuseppe Cirino , Giuseppe Caliendo , Anna Sparatore , Vicenzo Santagada , Stefano Fiorucci
IPC分类号: A61K31/655 , A61K31/60 , C07C241/00 , C07C229/00
CPC分类号: C07C323/59 , C07C323/60 , C07C327/42 , C07C327/48 , C07D339/04 , C07F9/3895 , C07F9/65785
摘要: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.
摘要翻译: 本发明提供4-或5-氨基水杨酸的新衍生物和含有这些4-或5-氨基水杨酸衍生物作为活性成分的药物组合物,其可用于治疗肠疾病如炎性肠病(IBD)和 肠易激综合征(IBS)和预防/治疗结肠癌。 更具体地说,这些衍生物包含通过偶氮,酯,酸酐,硫酯或酰胺键与4-或5-氨基水杨酸分子连接的硫化氢释放部分。 此外,本发明提供了制备这些化合物的方法及其用于治疗IBD和IBS以及预防/治疗结肠癌的用途。
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公开(公告)号:US08114858B2
公开(公告)日:2012-02-14
申请号:US12981008
申请日:2010-12-29
申请人: John L. Wallace , Giuseppe Cirino , Giuseppe Caliendo , Anna Sparatore , Vincenzo Santagada , Stefano Fiorucci
发明人: John L. Wallace , Giuseppe Cirino , Giuseppe Caliendo , Anna Sparatore , Vincenzo Santagada , Stefano Fiorucci
IPC分类号: A61K31/60 , C07D339/04
CPC分类号: C07C323/59 , C07C323/60 , C07C327/42 , C07C327/48 , C07D339/04 , C07F9/3895 , C07F9/65785
摘要: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.
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公开(公告)号:US07910568B2
公开(公告)日:2011-03-22
申请号:US11915305
申请日:2006-03-31
申请人: John L. Wallace , Giuseppe Cirino , Giuseppe Caliendo , Anna Sparatore , Vincenzo Santagada , Stefano Fiorucci
发明人: John L. Wallace , Giuseppe Cirino , Giuseppe Caliendo , Anna Sparatore , Vincenzo Santagada , Stefano Fiorucci
IPC分类号: A61K31/67 , C07D339/02
CPC分类号: C07C327/42 , C07C323/12 , C07C323/59 , C07C323/60 , C07C327/48 , C07D339/04 , C07F9/6578 , C07F9/6587
摘要: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.
摘要翻译: 本发明提供4-或5-氨基水杨酸的新衍生物和含有这些4-或5-氨基水杨酸衍生物作为活性成分的药物组合物,其可用于治疗肠疾病如炎性肠病(IBD)和 肠易激综合征(IBS)和预防/治疗结肠癌。 更具体地说,这些衍生物包含通过偶氮,酯,酸酐,硫酯或酰胺键与4-或5-氨基水杨酸分子连接的硫化氢释放部分。 此外,本发明提供了制备这些化合物的方法及其用于治疗IBD和IBS以及预防/治疗结肠癌的用途。
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公开(公告)号:US07879827B2
公开(公告)日:2011-02-01
申请号:US12368846
申请日:2009-02-10
申请人: John L. Wallace , Giuseppe Cirino , Giuseppe Caliendo , Anna Sparatore , Vincenzo Santagada , Stefano Fiorucci
发明人: John L. Wallace , Giuseppe Cirino , Giuseppe Caliendo , Anna Sparatore , Vincenzo Santagada , Stefano Fiorucci
IPC分类号: A61K31/655 , A61K31/603 , A61K31/606 , C07C243/10 , C07C229/48
CPC分类号: C07C323/59 , C07C323/60 , C07C327/42 , C07C327/48 , C07D339/04 , C07F9/3895 , C07F9/65785
摘要: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.
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公开(公告)号:US20090233886A1
公开(公告)日:2009-09-17
申请号:US12368846
申请日:2009-02-10
申请人: John L. Wallace , Giuseppe Cirino , Giuseppe Caliendo , Anna Sparatore , Vincenzo Santagada , Stefano Fiorucci
发明人: John L. Wallace , Giuseppe Cirino , Giuseppe Caliendo , Anna Sparatore , Vincenzo Santagada , Stefano Fiorucci
IPC分类号: A61K31/655 , A61K31/198
CPC分类号: C07C323/59 , C07C323/60 , C07C327/42 , C07C327/48 , C07D339/04 , C07F9/3895 , C07F9/65785
摘要: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.
摘要翻译: 本发明提供4-或5-氨基水杨酸的新衍生物和含有这些4-或5-氨基水杨酸衍生物作为活性成分的药物组合物,其可用于治疗肠疾病如炎性肠病(IBD)和 肠易激综合征(IBS)和预防/治疗结肠癌。 更具体地说,这些衍生物包含通过偶氮,酯,酸酐,硫酯或酰胺键与4-或5-氨基水杨酸分子连接的硫化氢释放部分。 此外,本发明提供了制备这些化合物的方法及其用于治疗IBD和IBS以及预防/治疗结肠癌的用途。
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公开(公告)号:US07498355B2
公开(公告)日:2009-03-03
申请号:US11278395
申请日:2006-03-31
申请人: John L. Wallace , Giuseppe Cirino , Giuseppe Caliendo , Anna Sparatore , Vincenzo Santagada , Stefano Fiorucci
发明人: John L. Wallace , Giuseppe Cirino , Giuseppe Caliendo , Anna Sparatore , Vincenzo Santagada , Stefano Fiorucci
IPC分类号: A61K31/381 , C07D339/04
CPC分类号: C07C323/59 , C07C323/60 , C07C327/42 , C07C327/48 , C07D339/04 , C07F9/3895 , C07F9/65785
摘要: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.
摘要翻译: 本发明提供4-或5-氨基水杨酸的新衍生物和含有这些4-或5-氨基水杨酸衍生物作为活性成分的药物组合物,其可用于治疗肠疾病如炎性肠病(IBD)和 肠易激综合征(IBS)和预防/治疗结肠癌。 更具体地说,这些衍生物包含通过偶氮,酯,酸酐,硫酯或酰胺键与4-或5-氨基水杨酸分子连接的硫化氢释放部分。 此外,本发明提供了制备这些化合物的方法及其用于治疗IBD和IBS以及预防/治疗结肠癌的用途。
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公开(公告)号:US20060270635A1
公开(公告)日:2006-11-30
申请号:US11139871
申请日:2005-05-27
申请人: John Wallace , Giuseppe Cirino , Giuseppe Caliendo , Anna Sparatore , Vincenzo Santagada , Stefano Fiorucci
发明人: John Wallace , Giuseppe Cirino , Giuseppe Caliendo , Anna Sparatore , Vincenzo Santagada , Stefano Fiorucci
IPC分类号: C07F9/02 , A61K31/385
CPC分类号: C07D339/04 , C07C323/59 , C07C323/60 , C07C327/42 , C07C327/48 , C07F9/3895
摘要: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.
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公开(公告)号:US20070197479A1
公开(公告)日:2007-08-23
申请号:US11278395
申请日:2006-03-31
申请人: John Wallace , Giuseppe Cirino , Giuseppe Caliendo , Anna Sparatore , Vincenzo Santagada , Stefano Fiorucci
发明人: John Wallace , Giuseppe Cirino , Giuseppe Caliendo , Anna Sparatore , Vincenzo Santagada , Stefano Fiorucci
CPC分类号: C07C323/59 , C07C323/60 , C07C327/42 , C07C327/48 , C07D339/04 , C07F9/3895 , C07F9/65785
摘要: The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.
摘要翻译: 本发明提供4-或5-氨基水杨酸的新衍生物和含有这些4-或5-氨基水杨酸衍生物作为活性成分的药物组合物,其可用于治疗肠疾病如炎性肠病(IBD)和 肠易激综合征(IBS)和预防/治疗结肠癌。 更具体地说,这些衍生物包含通过偶氮,酯,酸酐,硫酯或酰胺键与4-或5-氨基水杨酸分子连接的硫化氢释放部分。 此外,本发明提供了制备这些化合物的方法及其用于治疗IBD和IBS以及预防/治疗结肠癌的用途。
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公开(公告)号:US07326809B2
公开(公告)日:2008-02-05
申请号:US10908856
申请日:2005-05-27
申请人: John L. Wallace , Giuseppe Cirino , Anna Sparatore
发明人: John L. Wallace , Giuseppe Cirino , Anna Sparatore
IPC分类号: C07C229/00
CPC分类号: C07C279/14 , C07C229/64
摘要: The present invention provides L-arginine salts of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these L-arginine salts of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of an inflammatory condition of the GI tract such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS).
摘要翻译: 本发明提供4-或5-氨基水杨酸的L-精氨酸盐,以及含有这些4-或5-氨基水杨酸的L-精氨酸盐作为活性成分的药物组合物,其用于治疗胃肠炎 肠炎如肠炎(IBD)和肠易激综合征(IBS)。
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