公开(公告)号：US20050148506A1

公开(公告)日：2005-07-07

申请号：US10823998

申请日：2004-04-14

申请人： Julia Billiard ,  Peter Bodine

发明人： Julia Billiard ,  Peter Bodine

IPC分类号： A61K38/17 ,  A61K38/18 ,  C07H21/04 ,  C07K14/51 ,  C12N9/12 ,  C12N9/64 ,  C12Q1/68

CPC分类号： C12N15/1138 ,  A61K38/00 ,  A61K38/179 ,  C07K14/51 ,  C12N9/1205 ,  C12N2310/14 ,  G01N2333/51

摘要： This invention relates to modulating bone-related activity in a subject by modulating Ror molecules. The invention further relates to compositions and methods for the screening, diagnosis and development of therapies for bone-related disorders. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

摘要翻译： 本发明涉及通过调节Ror分子调节受试者的骨相关活性。 本发明还涉及用于骨相关疾病疗法的筛选，诊断和开发的组合物和方法。 要强调的是，该摘要被提供以符合要求抽象的规则，允许搜索者或其他读者快速确定技术公开内容的主题。 提交它的理解是，它不会用于解释或限制权利要求的范围或含义。

公开(公告)号：US20080166356A9

公开(公告)日：2008-07-10

申请号：US10666851

申请日：2003-09-19

申请人： Peter Bodine

发明人： Peter Bodine

IPC分类号： A61K39/395 ,  A61K38/17 ,  A61K48/00

CPC分类号： A61K38/1709 ,  A61K48/00 ,  C07K16/18

摘要： Pharmaceutical compositions and methods of use in regulation of mammalian bone forming activities of sFRPs (secreted frizzled-related proteins) are disclosed. sFRPs are secreted receptors for Wnts, which are important polypeptide growth factors that are known to regulate fundamental biological processes like tissue polarity, embryonic development, and tumorigenesis. A sFRP was isolated from human osteoblast cells and identified as sFRP-1 (also known as SARP-2) and shown to be regulated by osteogenic agents in hOB cells in a differentiation selective manner, modulating the life of osteoblasts/preosteocytes. An sFRP-1 knock-out mouse was generated and deletion of sFRP-1 was found to not affect nonskeletal tissues, skeletal morphology or cortical bone development, while resulting in increased trabecular bone formation, decreased osteoblast and osteocyte apoptosis and increased osteoprogenitor differentiation.

摘要翻译： 公开了用于调节sFRP（分泌的卷曲相关蛋白）的哺乳动物骨形成活性的药物组合物和方法。 sFRPs是Wnts的分泌受体，其是已知调节基本生物学过程如组织极性，胚胎发育和肿瘤发生的重要多肽生长因子。 从人成骨细胞中分离sFRP，并鉴定为sFRP-1（也称为SARP-2），并以分化选择性方式显示在成骨细胞中由成骨细胞调节，调节成骨细胞/前胚细胞的寿命。 产生sFRP-1敲除小鼠，发现sFRP-1的缺失不影响非骨骼组织，骨骼形态或皮质骨发育，同时导致小梁骨形成增加，成骨细胞和骨细胞凋亡降低，骨祖细胞分化增加。

公开(公告)号：US20070072239A1

公开(公告)日：2007-03-29

申请号：US11515501

申请日：2006-09-01

申请人： Ramesh Bhat ,  Peter Bodine

发明人： Ramesh Bhat ,  Peter Bodine

IPC分类号： G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C12N5/08

CPC分类号： C07K14/71 ,  G01N33/74 ,  G01N2500/00

摘要： Methods and pharmaceutical compositions of use in regulation of mammalian bone-forming activities of SFRPs (secreted frizzled-related proteins) are disclosed. SFRPs are secreted receptors for Wnts, which are important polypeptide growth factors that are known to regulate fundamental biological processes such as tissue polarity, embryonic development, and tumorigenesis. Methods can be used to identify compounds which target the Wnt-antagonizing function of an SFRP by way of one or more domains or specific amino acids. Pharmaceutical compositions can be prepared using these compounds, and bone disorders can be treated using these pharmaceutical compositions.

摘要翻译： 公开了用于调节SFRP（分泌的卷曲相关蛋白）的哺乳动物骨形成活性的方法和药物组合物。 SFRP是Wnts的分泌受体，其是已知调节基本生物学过程如组织极性，胚胎发育和肿瘤发生的重要多肽生长因子。 方法可用于鉴定通过一个或多个结构域或特定氨基酸靶向SFRP的Wnt拮抗功能的化合物。 可以使用这些化合物制备药物组合物，并且可以使用这些药物组合物治疗骨骼疾病。