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1.发明公开公开(公告)号：US20240319211A1
公开(公告)日：2024-09-26
申请号：US18576005
申请日：2023-05-08
Inventor： Jun PENG , Zhenzuo JIANG
CPC classification number: G01N33/74 , B01D61/145 , B01D61/243 , G01N33/6848
Abstract: The present invention belongs to the field of free components detection technologies. For sample preparation of free components, although ultrafiltration is efficient and fast, the temperature is not easy to control which result in the measurement results have a large deviation. Conversely, the temperature is easy to control and measurement results are more precise when equilibrium dialysis is used. However, a long time consumed gives rise to equilibrium dialysis cannot meet the requirement for quickly analyzing clinical biological samples. Therefore, this application provides a content conversion method of free components by transforming ultrafiltration to equilibrium dialysis. Free components are separated from samples by ultrafiltration to obtain first concentration. Meanwhile, free components are separated from the samples by equilibrium dialysis to obtain second concentration. A linear equation is established based on the first concentration and the second concentration, which can meet both requirements of high detection accuracy and short time consuming.
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公开(公告)号：US12099060B2
公开(公告)日：2024-09-24
申请号：US16839623
申请日：2020-04-03
Applicant: Seoul National University R&DB Foundation
Inventor： Tai Hyun Park , Seung Hun Hong , Hyun Seok Song , Hye Jun Jin , Sae Ryun Ahn
IPC: G01N21/64 , B01F23/00 , B01F23/41 , B01F101/23 , B23Q17/24 , C07K14/705 , C12M1/34 , C12Q1/04 , C12Q1/18 , C12Q1/686 , G01N21/3577 , G01N21/359 , G01N21/39 , G01N21/45 , G01N27/414 , G01N30/12 , G01N30/68 , G01N30/70 , G01N30/72 , G01N30/88 , G01N33/00 , G01N33/18 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/68 , G01N33/74 , H10K10/46 , H10K85/00 , H10K85/20
CPC classification number: G01N33/5438 , C07K14/705 , G01N27/4145 , G01N33/5308 , G01N33/54373 , G01N33/74 , H10K10/46 , H10K85/761 , G01N2333/705 , G01N2333/726 , G01N2400/00 , H10K85/225
Abstract: The present invention relates to a nanovesicle comprising a heterodimeric G-protein coupled receptor, a method for preparing the nanovesicle, a field effect transistor-based taste sensor comprising the nanovesicle, and a method for manufacturing the taste sensor. The field effect transistor based taste sensor functionalized by the nanovesicle comprising the heterodimer G-protein coupled receptor according to the present invention has excellent sensitivity and selectivity and may highly specifically detect a sweet taste substance in real time, by using the heterodimeric G-protein coupled receptor and the nanovesicle comprising the same.
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公开(公告)号：US12076370B2
公开(公告)日：2024-09-03
申请号：US17576886
申请日：2022-01-14
Inventor： Mingdong Zhou
CPC classification number: A61K38/1883 , A61K9/0019 , A61K45/06 , C07K14/4756 , G01N33/6893 , G01N33/74 , G01N2333/58 , G01N2800/325 , G01N2800/52
Abstract: The present invention provides methods for treating chronic heart failure patients using the medication comprising neuregulin. The methods comprise first performing a companion diagnostic test of each patient before treatment; and then providing a suitable treatment to the patient according to the results of the companion diagnostic test. When the result of the test is within a favorite treatment zone, the patient is suitable for heart failure treatment by administering an effective amount of neuregulin.
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公开(公告)号：US12029780B2
公开(公告)日：2024-07-09
申请号：US17549017
申请日：2021-12-13
Applicant: OPKO BIOLOGICS LTD.
Inventor： Fuad Fares , Udi Eyal Fima
IPC: A61K38/27 , A61K38/24 , A61K47/00 , A61K47/02 , A61K47/12 , C07K14/475 , C07K14/505 , C07K14/555 , C07K14/59 , C07K14/61 , C07K19/00 , G01N33/74
CPC classification number: A61K38/27 , A61K38/24 , A61K47/02 , A61K47/12 , C07K14/505 , C07K14/555 , C07K14/59 , C07K14/61 , G01N33/74 , C07K2319/00 , C07K2319/31 , G01N2333/65 , G01N2800/52
Abstract: CTP-modified human growth hormone polypeptides and pharmaceutical formulations and pharmaceutical compositions comprising the same and methods of producing, and using the same are disclosed.
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公开(公告)号：US20240219394A1
公开(公告)日：2024-07-04
申请号：US18432550
申请日：2024-02-05
Applicant: AJINOMOTO CO., INC.
Inventor： Chiori IJICHI , Yusuke IHARA , Yasuko SOMEKAWA , Yayoi KAWATO , Sachise KARAKAWA
CPC classification number: G01N33/68 , G01N33/74 , G01N2333/726 , G01N2500/04 , G01N2500/10
Abstract: A method for measuring a response of an olfactory receptor to a substance is provided. The test substance and the olfactory receptor are contacted under such a condition that response of adenosine receptor to the test substance is reduced, and response of the olfactory receptor to the test substance is measured.
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Patent Agency Ranking
公开(公告)号：US12000845B2
公开(公告)日：2024-06-04
申请号：US17710369
申请日：2022-03-31
Applicant: B.R.A.H.M.S GmbH
Inventor： Aline Pehla , Stefan Kirsch , Darius Wilson
CPC classification number: G01N33/74 , G01N33/86 , G01N2800/222 , G01N2800/50 , G01N2800/52
Abstract: The invention relates to a method for determining, diagnosis, prognosis, treatment guidance, treatment monitoring, risk assessment and/or risk stratification of patients with abnormal platelet levels comprising providing a sample of said patient, determining a level of proadrenomedullin (proADM) or fragment(s) thereof in said sample, wherein said level of proADM or fragment(s) thereof correlates with the abnormal platelet levels in said patient. In embodiments of the invention, a level of proADM or fragment(s) thereof of high severity indicates low platelet levels in the subject and subsequent initiating or modifying a treatment of the patient to improve said condition. In some embodiments of the invention the method comprises determining a level of one or more additional markers in a sample isolated from the patient, such as the level of platelets, the level of PCT or fragment(s) thereof, one or more markers of thrombocytopenia and/or one or more markers of an inflammatory response.
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公开(公告)号：US20240151714A1
公开(公告)日：2024-05-09
申请号：US18281460
申请日：2022-03-14
Inventor： Tae Hyeon YOO , Hyeon Ji PARK
IPC: G01N33/53 , G01N33/573 , G01N33/68 , G01N33/74 , G01N33/76
CPC classification number: G01N33/5308 , G01N33/573 , G01N33/6887 , G01N33/74 , G01N33/76 , G01N2333/4712 , G01N2333/59 , G01N2333/71 , G01N2333/96463
Abstract: The present invention relates to a target analyte detection composition based on a proximity proteolysis reaction and a target analyte detection method using same. More specifically, the present invention relates to a method for detecting a target analyte, the method comprising a step in which when a first binder and a second binder bind to the target analyte, hybridization is made between ssDNA linked to the first binder and ssDNA linked to a protease and between ssDNA linked to the second binder and ssDNA linked to a zymogen, whereby a signal generated by a proximity proteolysis reaction between the protease and the zymogen is detected.
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公开(公告)号：US20240142474A1
公开(公告)日：2024-05-02
申请号：US18547840
申请日：2022-02-24
Applicant: The Regents of the University of California
Inventor： Craig Montell , Yinpeng Zhan , Avinash Chandel
IPC: G01N33/74 , A01K67/0276
CPC classification number: G01N33/74 , A01K67/0276 , A01K2217/054 , A01K2227/105 , G01N2333/726
Abstract: Opsin proteins are GPCRs known for light perception. Here it is shown that these receptors are also expressed in chemosensory cells and function as chemosensory receptors activated by a range of molecules, including tastants such as theobromine, for which a receptor has not previously been known. Provided are novel assay systems for assessing chemosensory opsin activation by chemical ligands. By these assays, novel ligands of chemosensory opsins may be identified, the chemosensory properties of molecules may be evaluated; and the modulation of chemosensory properties by modifications or modulators may be tested.
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公开(公告)号：US20240133901A1
公开(公告)日：2024-04-25
申请号：US18278756
申请日：2022-02-24
Applicant: FUJIFILM Wako Pure Chemical Corporation
Inventor： Masaaki KOJIMA , Fumie AKUTSU
CPC classification number: G01N33/74 , G01N1/34 , G01N2410/04
Abstract: An object of the present invention is to provide a simple purifying method, measuring method, and kit. The present invention is an oxytocin purifying method including treating a sample with an acid or a salt thereof, and treating the sample treated with the acid or the salt thereof with a hydrophobic carrier, and related to the purifying method, measuring method including the purifying method, and kit, in which the acid or the salt thereof is at least one or more acids or salts thereof selected from the group consisting of hydrochloric acid, acetic acid, sulfuric acid, sodium hydrogensulfate, potassium hydrogensulfate, lithium hydrogensulfate, ammonium sulfate, and a mixture thereof, and the hydrophobic carrier is a hydrophobic carrier having at least one or more functional groups on the surface, selected from the group consisting of an alkyl group having 4 to 6 carbon atoms, an alkylene glycol group, and a phenyl group.
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公开(公告)号：US11918557B2
公开(公告)日：2024-03-05
申请号：US18183655
申请日：2023-03-14
Applicant: Vanda Pharmaceuticals Inc.
IPC: A61K31/343 , A61K9/00 , A61K31/00 , A61K31/15 , A61K31/277 , A61K31/496 , A61K45/06 , A61P25/20 , G01N30/72 , G01N33/68 , G01N33/74 , G16H50/20
CPC classification number: A61K31/343 , A61K9/0053 , A61K9/006 , A61K31/00 , A61K31/15 , A61K31/277 , A61K31/496 , A61K45/06 , A61P25/20 , G01N30/7233 , G01N33/6893 , G01N33/74 , G16H50/20 , G01N2800/2864
Abstract: Embodiments of the invention relate to the use of a melatonin agonist in the treatment of free running circadian rhythms in patients, including light perception impaired patients, e.g., blind patients, and to methods of measuring circadian rhythm.
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