公开(公告)号：US20160206214A1

公开(公告)日：2016-07-21

申请号：US15081323

申请日：2016-03-25

申请人： Justin Davies ,  Joseph Burnett ,  Neil Hattangadi ,  David Anderson ,  Helen Catherine Stuart Davies

发明人： Justin Davies ,  Joseph Burnett ,  Neil Hattangadi ,  David Anderson ,  Helen Catherine Stuart Davies

IPC分类号： A61B5/02 ,  A61B5/00 ,  A61B5/0215

CPC分类号： A61B5/02007 ,  A61B5/0215 ,  A61B5/02158 ,  A61B5/6852 ,  A61B5/742 ,  A61B34/10

摘要： Embodiments of the present disclosure are configured to assess the severity of a blockage in a vessel and, in particular, a stenosis in a blood vessel. In some particular embodiments, the devices, systems, and methods of the present disclosure are configured to assess the severity of a stenosis in the coronary arteries without the administration of a hyperemic agent.

公开(公告)号：US09339348B2

公开(公告)日：2016-05-17

申请号：US13460296

申请日：2012-04-30

申请人： Justin Davies ,  Joseph Burnett ,  Neil Hattangadi ,  David Anderson ,  Helen Catherine Stuart Davies

发明人： Justin Davies ,  Joseph Burnett ,  Neil Hattangadi ,  David Anderson ,  Helen Catherine Stuart Davies

IPC分类号： A61B5/02 ,  A61B19/00 ,  A61B5/0215

CPC分类号： A61B5/02007 ,  A61B5/0215 ,  A61B5/02158 ,  A61B5/6852 ,  A61B5/742 ,  A61B34/10

摘要： Embodiments of the present disclosure are configured to assess the severity of a blockage in a vessel and, in particular, a stenosis in a blood vessel. In some particular embodiments, the devices, systems, and methods of the present disclosure are configured to assess the severity of a stenosis in the coronary arteries without the administration of a hyperemic agent.

摘要翻译： 本公开的实施例被配置为评估血管中的阻塞的严重性，特别是血管中的狭窄。 在一些特定实施例中，本公开的装置，系统和方法被配置为评估冠状动脉狭窄的严重性，而不施用充血剂。

公开(公告)号：US08162879B2

公开(公告)日：2012-04-24

申请号：US12564771

申请日：2009-09-22

申请人： Neil Hattangadi ,  Daniel Lerner ,  Ryan Olivera

发明人： Neil Hattangadi ,  Daniel Lerner ,  Ryan Olivera

IPC分类号： A61M29/00

CPC分类号： A61M25/1011 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61M25/007 ,  A61M2025/1052

摘要： The invention, in one embodiment, is directed to a catheter for site-specific delivery of a therapeutic agent to a blood vessel of a patient. The catheter further includes an elongated shaft having at least one inner lumen, a distal end and a proximal end and proximal and distal vessel-conforming balloons where each is separately positionable and inflatable, and when inflated, substantially restricts blood flow in the vessel and creates a treatment window of a defined but variable length for delivery of the therapeutic agent. The catheter optionally includes at least one marker band adjacent to the proximal balloon and at least one marker band adjacent to the distal balloon. At least one lateral aperture positioned in the window is in fluid communication with a drug delivery conduit located within either the inner shaft or the outer shaft to provide a homogeneous concentration of the therapeutic agent to the window.

摘要翻译： 在一个实施方案中，本发明涉及用于将治疗剂的位点特异性递送给患者的血管的导管。 导管还包括细长轴，其具有至少一个内腔，远端和近端以及近端和远侧容器构造的气囊，其中每个气囊均可分开定位和充气，并且当充气时，基本上限制血管中的血流并产生 用于递送治疗剂的具有限定但可变长度的治疗窗。 导管可选地包括与近端球囊相邻的至少一个标记带和与远端球囊相邻的至少一个标记带。 定位在窗口中的至少一个侧向孔与位于内轴或外轴内的药物输送导管流体连通，以提供治疗剂到窗口的均匀浓度。

公开(公告)号：US08603064B2

公开(公告)日：2013-12-10

申请号：US13446400

申请日：2012-04-13

申请人： Neil Hattangadi ,  Daniel Lerner ,  Ryan Olivera

发明人： Neil Hattangadi ,  Daniel Lerner ,  Ryan Olivera

IPC分类号： A61M31/00

CPC分类号： A61M25/1011 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61M25/007 ,  A61M2025/1052

摘要： The present disclosure is directed to a catheter for site-specific delivery of a therapeutic agent to a blood vessel of a patient. The catheter further includes an elongated shaft having at least one inner lumen, a distal end and a proximal end and proximal and distal vessel-conforming balloons where each is separately positionable and inflatable, and when inflated, substantially restricts blood flow in the vessel and creates a treatment window of a defined but variable length for delivery of the therapeutic agent. The catheter optionally includes at least one marker band adjacent to the proximal balloon and at least one marker band adjacent to the distal balloon. At least one lateral aperture positioned in the window is in fluid communication with a drug delivery conduit located within either the inner shaft or the outer shaft to provide a homogeneous concentration of the therapeutic agent to the window.

摘要翻译： 本公开涉及用于将治疗剂的位点特异性递送给患者的血管的导管。 导管还包括细长轴，其具有至少一个内腔，远端和近端以及近端和远侧容器构造的气囊，其中每个气囊均可分开定位和充气，并且当充气时，基本上限制血管中的血流并产生 用于递送治疗剂的具有限定但可变长度的治疗窗。 导管可选地包括与近端球囊相邻的至少一个标记带和与远端球囊相邻的至少一个标记带。 定位在窗口中的至少一个侧向孔与位于内轴或外轴内的药物输送导管流体连通，以提供治疗剂到窗口的均匀浓度。

公开(公告)号：US20100082012A1

公开(公告)日：2010-04-01

申请号：US12564771

申请日：2009-09-22

申请人： Neil Hattangadi ,  Daniel Lerner ,  Ryan Olivera

发明人： Neil Hattangadi ,  Daniel Lerner ,  Ryan Olivera

IPC分类号： A61M25/10

CPC分类号： A61M25/1011 ,  A61L29/16 ,  A61L2300/416 ,  A61L2300/602 ,  A61M25/007 ,  A61M2025/1052

摘要： The invention, in one embodiment, is directed to a catheter for site-specific delivery of a therapeutic agent to a blood vessel of a patient. The catheter further includes an elongated shaft having at least one inner lumen, a distal end and a proximal end and proximal and distal vessel-conforming balloons where each is separately positionable and inflatable, and when inflated, substantially restricts blood flow in the vessel and creates a treatment window of a defined but variable length for delivery of the therapeutic agent. The catheter optionally includes at least one marker band adjacent to the proximal balloon and at least one marker band adjacent to the distal balloon. At least one lateral aperture positioned in the window is in fluid communication with a drug delivery conduit located within either the inner shaft or the outer shaft to provide a homogeneous concentration of the therapeutic agent to the window.

摘要翻译： 在一个实施方案中，本发明涉及用于将治疗剂的位点特异性递送给患者的血管的导管。 导管还包括细长轴，其具有至少一个内腔，远端和近端以及近端和远侧容器构造的气囊，其中每个气囊均可分开定位和充气，并且当充气时，基本上限制血管中的血流并产生 用于递送治疗剂的具有限定但可变长度的治疗窗。 导管可选地包括与近端球囊相邻的至少一个标记带和与远端球囊相邻的至少一个标记带。 定位在窗口中的至少一个侧向孔与位于内轴或外轴内的药物输送导管流体连通，以提供治疗剂到窗口的均匀浓度。