公开(公告)号：US20180099107A1

公开(公告)日：2018-04-12

申请号：US15291028

申请日：2016-10-11

Applicant: KAER BIOTHERAPEUTICS CORPORATION

Inventor： Donovan B. Yeates ,  Xin Heng

IPC: A61M11/02 ,  A61M16/12 ,  B05B7/04

CPC classification number: A61M11/02 ,  A61M11/002 ,  A61M11/006 ,  A61M11/06 ,  A61M15/0086 ,  A61M16/125 ,  A61M2202/0208 ,  A61M2202/0488 ,  A61M2202/064 ,  B05B7/0416 ,  A61M2202/0007

Abstract: A system and a method for generating a respirable dry powder aerosol (15) from a liquid solution or liquid suspension at a respirable dry powder aerosol volume flow (91). A liquid aerosol generating nozzle (3) generates from the liquid solution or liquid suspension a liquid aerosol (13) that is diluted by dilution gas (4) and dried in a cylindrical evaporation chamber (6) to generate a dry powder aerosol (14) that is subsequently concentrated by a cylindrical single linear slit aerosol concentrator (9). The system and method may include heliox as a gas, specifically dilution gas (4), for enhancing both the drying process in the cylindrical evaporation chamber (6) and for enhancing the concentration efficiency, but also as a nozzle gas (2) for enhancing generating the liquid aerosol (13) from the liquid solution or liquid suspension.

公开(公告)号：US20240399079A1

公开(公告)日：2024-12-05

申请号：US18206062

申请日：2023-06-05

Applicant: KAER BIOTHERAPEUTICS CORPORATION

Inventor： Donovan B. Yeates

IPC: A61M15/00

Abstract: An aerosol concentrator dividing an input aerosol into a respirable aerosol of an increased particle concentration and an exhaust aerosol of a lower particle concentration. The concentrator comprises a cross-slit of an input tube and output tube with a gap between the cross-slits of input tube and the output tube. A housing encompasses a plenum which encompasses the gap and is connected to an exhaust port through which an exhaust aerosol exits the plenum. A radial size of the plenum is can be significantly larger than the length of the slits in the cross-slit.

公开(公告)号：US20200276400A1

公开(公告)日：2020-09-03

申请号：US16872339

申请日：2020-05-11

Applicant: KAER BIOTHERAPEUTICS CORPORATION

Inventor： Donovan B. Yeates

IPC: A61M11/02 ,  A61M16/12 ,  B05B7/04 ,  A61M15/00 ,  A61M11/00 ,  A61M11/06 ,  F26B3/12

Abstract: An aerosol generating system for generating a respirable dry powder aerosol from a liquid solution or liquid suspension, having: a liquid aerosol generating nozzle having a nozzle input end designed to receive the liquid solution or liquid suspension, and having a nozzle heliox supply designed to receive nozzle heliox, the liquid aerosol generating nozzle further having a nozzle output end for outputting a liquid aerosol suspended in the nozzle heliox; and a cylindrical evaporation chamber having a cylindrical evaporation chamber input end that is connected to the nozzle output end and connected to a dilution heliox supply for receiving both the liquid aerosol suspended in the nozzle heliox and for receiving the dilution heliox, and the cylindrical evaporation chamber having a cylindrical evaporation chamber output end outputting a first intermediate dry powder aerosol at a first intermediate dry powder aerosol volume flow of a specific concentration.

公开(公告)号：US20180221596A1

公开(公告)日：2018-08-09

申请号：US15947703

申请日：2018-04-06

Applicant: KAER BIOTHERAPEUTICS CORPORATION

Inventor： Donovan B. Yeates ,  Xin Heng

IPC: A61M11/02 ,  B05B7/04 ,  A61M16/12

CPC classification number: A61M11/02 ,  A61M11/002 ,  A61M11/006 ,  A61M11/06 ,  A61M15/0086 ,  A61M16/125 ,  A61M2202/0208 ,  A61M2202/0488 ,  A61M2202/064 ,  B05B7/0416 ,  F26B3/12 ,  A61M2202/0007

Abstract: A system and a method for generating a respirable dry powder aerosol (15) from a liquid solution or liquid suspension at a respirable dry powder aerosol volume flow (91). A liquid aerosol generating nozzle (3) generates from the liquid solution or liquid suspension a liquid aerosol (13) that is diluted by dilution gas (4) and dried in a cylindrical evaporation chamber (6) to generate a dry powder aerosol (14) that is subsequently concentrated. The system and method may include heliox as a gas, specifically dilution gas (4), for enhancing both the drying process in the cylindrical evaporation chamber (6) and for enhancing the concentration efficiency, but also as a nozzle gas (2) for enhancing generating the liquid aerosol (13) from the liquid solution or liquid suspension.

公开(公告)号：US20170296761A1

公开(公告)日：2017-10-19

申请号：US15425529

申请日：2017-02-06

Applicant: KAER BIOTHERAPEUTICS CORPORATION

Inventor： Donovan B. Yeates ,  Xin Heng

IPC: A61M11/06 ,  A61M11/00 ,  B05B1/02 ,  B05B7/04

CPC classification number: A61M11/06 ,  A61M11/001 ,  A61M2202/064 ,  B05B1/02 ,  B05B7/0475 ,  B05B7/0483 ,  B05B7/068 ,  B05B7/10 ,  B05B7/12

Abstract: A nozzle and a method of generating an inhalable aerosol from a liquid solution or liquid suspension and a gas by operating the nozzle. A column-like aerosol plume is generated having fluid particles within a particle free sheath of gas, the aerosol plume being generated from a compressed gas interacting within the aerosolizing space with a fluid ejected along the central axis, and generates a Venturi effect entraining gas that flows over the convex outer nozzle surface that together with the particle free sheath keeps the circumferential edge and the outer nozzle surface free of particle deposition. An aerosol exit orifice diameter is at least 1.3 times larger than the fluid exit orifice diameter; and a converging annular pressurized gas channel extending at an acute gas flow angle of 10-30° with respect to a central axis.