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    Apparatus and method for generating and concentrating fine particle aerosols
    1.
    发明授权
    Apparatus and method for generating and concentrating fine particle aerosols 有权

    公开(公告)号：US10207062B2

    公开(公告)日：2019-02-19

    申请号：US15291020

    申请日：2016-10-11

    Applicant: KAER BIOTHERAPEUTICS CORPORATION

    Inventor： Donovan B Yeates ,  Xin Heng

    IPC: A61M11/02 ,  A61M11/00 ,  A61M15/00 ,  A61M16/14 ,  A61M11/04 ,  A61M11/06 ,  A61M16/00

    Abstract: A system and a method for generating a respirable dry powder aerosol (15) from a liquid solution or liquid suspension at a respirable dry powder aerosol volume flow (91). A liquid aerosol generating nozzle (3) generates from the liquid solution or liquid suspension a liquid aerosol (13) that is diluted by dilution gas (4) and dried in a cylindrical evaporation chamber (6) to generate a dry powder aerosol (14) that is subsequently concentrated by a cylindrical single linear slit aerosol concentrator (9). The system and method may include heliox as a gas, specifically dilution gas (4), for enhancing both the drying process in the cylindrical evaporation chamber (6) and for enhancing the concentration efficiency, but also as a nozzle gas (2) for enhancing generating the liquid aerosol (13) from the liquid solution or liquid suspension.

    Apparatus and method for generating particle aerosols with heliox
    4.
    发明授权
    Apparatus and method for generating particle aerosols with heliox 有权

    公开(公告)号：US10688257B2

    公开(公告)日：2020-06-23

    申请号：US15947703

    申请日：2018-04-06

    Applicant: KAER BIOTHERAPEUTICS CORPORATION

    Inventor： Donovan B Yeates ,  Xin Heng

    IPC: A61M11/00 ,  A61M11/02 ,  A61M16/12 ,  B05B7/04 ,  A61M15/00 ,  A61M11/06 ,  F26B3/12

    Abstract: A system and a method for generating a respirable dry powder aerosol (15) from a liquid solution or liquid suspension at a respirable dry powder aerosol volume flow (91). A liquid aerosol generating nozzle (3) generates from the liquid solution or liquid suspension a liquid aerosol (13) that is diluted by dilution gas (4) and dried in a cylindrical evaporation chamber (6) to generate a dry powder aerosol (14) that is subsequently concentrated. The system and method may include heliox as a gas, specifically dilution gas (4), for enhancing both the drying process in the cylindrical evaporation chamber (6) and for enhancing the concentration efficiency, but also as a nozzle gas (2) for enhancing generating the liquid aerosol (13) from the liquid solution or liquid suspension.

    Aerosolizing nozzle and method of operating such aerosolizing nozzle
    6.
    发明授权
    Aerosolizing nozzle and method of operating such aerosolizing nozzle 有权
    气雾喷嘴及其操作方法

    公开(公告)号：US09573147B1

    公开(公告)日：2017-02-21

    申请号：US15130235

    申请日：2016-04-15

    Applicant: KAER BIOTHERAPEUTICS CORPORATION

    Inventor： Donovan B Yeates ,  Xin Heng

    IPC: B05B7/04 ,  B05B1/02 ,  A61M11/06 ,  A61M11/00 ,  B05B7/12 ,  B05B7/10

    CPC classification number: A61M11/06 ,  A61M11/001 ,  A61M2202/064 ,  B05B1/02 ,  B05B7/0475 ,  B05B7/0483 ,  B05B7/068 ,  B05B7/10 ,  B05B7/12

    Abstract: A nozzle and a method of generating an aerosol from a fluid and a gas by operating the nozzle. The nozzle has an aerosol exit orifice of a larger diameter and a fluid exit orifice of a smaller diameter aligned on a common central axis. A pressurized gas from a pressurized gas exit in close proximity to the fluid exit orifice intersects a fluid jet exiting from the fluid exit orifice at that acute angle and in a distance from the aerosol exit orifice. The method includes aerosolizing a fluid with a viscosity exceeding 4 cSt delivering an inhalable medication at a rate of more than 1 ml/minute, thereby delivering a medication at a mass flow rate of at least 30 mg/minute in form of the fluid particles having a mass median aerodynamic diameter (MMAD) of 6 μm or less.

    Abstract translation: 喷嘴和通过操作喷嘴从流体和气体产生气溶胶的方法。 喷嘴具有较大直径的气溶胶出口孔和较小直径的流体出口孔，其在公共中心轴线上对准。 来自紧邻流体出口孔的加压气体出口的加压气体以从该流体出口孔流出的流体喷流以与该气溶胶出口孔相距的锐角相交。 该方法包括使粘度超过4cSt的流体雾化，以大于1ml /分钟的速率递送可吸入药物，从而以至少30mg /分钟的质量流速递送药物，形式为具有 质量中值空气动力学直径（MMAD）为6μm以下。

    Aerosolizing nozzle and method of operating such aerosolizing nozzle
    7.
    发明授权
    Aerosolizing nozzle and method of operating such aerosolizing nozzle 有权

    公开(公告)号：US10661033B2

    公开(公告)日：2020-05-26

    申请号：US15425529

    申请日：2017-02-06

    Applicant: KAER BIOTHERAPEUTICS CORPORATION

    Inventor： Donovan B Yeates ,  Xin Heng

    IPC: B05B7/04 ,  B05B1/02 ,  B05B7/12 ,  B05B7/10 ,  B05B7/06 ,  A61M11/06 ,  A61M11/00

    Abstract: A nozzle and a method of generating an inhalable aerosol from a liquid solution or liquid suspension and a gas by operating the nozzle. A column-like aerosol plume is generated having fluid particles within a particle free sheath of gas, the aerosol plume being generated from a compressed gas interacting within the aerosolizing space with a fluid ejected along the central axis, and generates a Venturi effect entraining gas that flows over the convex outer nozzle surface that together with the particle free sheath keeps the circumferential edge and the outer nozzle surface free of particle deposition. An aerosol exit orifice diameter is at least 1.3 times larger than the fluid exit orifice diameter; and a converging annular pressurized gas channel extending at an acute gas flow angle of 10-30° with respect to a central axis.

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