公开(公告)号：US20180155317A1

公开(公告)日：2018-06-07

申请号：US15651856

申请日：2017-07-17

Applicant: Karyopharm Therapeutics Inc.

Inventor： Erkan Baloglu ,  Sharon Shacham ,  Dilara McCauley ,  Trinayan Kashyap ,  William Senapedis ,  Yosef Landesman ,  Gali Golan ,  Ori Kalid ,  Sharon Shechter

IPC: C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06 ,  C07D249/08

CPC classification number: C07D401/06 ,  C07D249/08 ,  C07D403/06 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06

Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I or their pharmaceutically acceptable salts, and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.

公开(公告)号：US11945794B2

公开(公告)日：2024-04-02

申请号：US17409150

申请日：2021-08-23

Applicant: Karyopharm Therapeutics Inc.

Inventor： Erkan Baloglu ,  Sharon Shacham ,  Dilara McCauley ,  Trinayan Kashyap ,  William Senapedis ,  Yosef Landesman ,  Gali Golan ,  Ori Kalid ,  Sharon Shechter

IPC: C07D249/08 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/501 ,  A61K31/506 ,  A61P3/04 ,  A61P11/00 ,  A61P17/02 ,  A61P25/00 ,  A61P25/28 ,  A61P27/02 ,  A61P29/00 ,  A61P31/12 ,  A61P35/00 ,  A61P37/00 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06

CPC classification number: C07D401/06 ,  C07D249/08 ,  C07D403/06 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06

Abstract: The present invention relates to compounds of formula I:




and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I or their pharmaceutically acceptable salts, and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.

公开(公告)号：US09738624B2

公开(公告)日：2017-08-22

申请号：US14900469

申请日：2014-06-20

Applicant: Karyopharm Therapeutics Inc.

Inventor： Erkan Baloglu ,  Sharon Shacham ,  Dilara McCauley ,  Trinayan Kashyap ,  William Senapedis ,  Yosef Landesman ,  Gali Golan ,  Ori Kalid ,  Sharon Shechter

IPC: A61K31/4196 ,  C07D249/08 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06 ,  C07D417/06 ,  C07D405/06

CPC classification number: C07D401/06 ,  C07D249/08 ,  C07D403/06 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06

Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula (I) or their pharmaceutically acceptable salts, and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.

公开(公告)号：US20250059158A1

公开(公告)日：2025-02-20

申请号：US18586019

申请日：2024-02-23

Applicant: Karyopharm Therapeutics Inc.

Inventor： Erkan Baloglu ,  Sharon Shacham ,  Dilara McCauley ,  Trinayan Kashyap ,  William Senapedis ,  Yosef Landesman ,  Gali Golan ,  Ori Kalid ,  Sharon Shedhter

IPC: C07D401/06 ,  C07D249/08 ,  C07D403/06 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06

Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I or their pharmaceutically acceptable salts, and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.

公开(公告)号：US11124493B2

公开(公告)日：2021-09-21

申请号：US16519955

申请日：2019-07-23

Applicant: Karyopharm Therapeutics Inc.

Inventor： Erkan Baloglu ,  Sharon Shacham ,  Dilara McCauley ,  Trinayan Kashyap ,  William Senapedis ,  Yosef Landesman ,  Gali Golan ,  Ori Kalid ,  Sharon Shechter

IPC: A61K31/506 ,  A61P35/00 ,  C07D403/06 ,  C07D401/06 ,  C07D249/08 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06

Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I or their pharmaceutically acceptable salts, and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.

公开(公告)号：US10407405B2

公开(公告)日：2019-09-10

申请号：US15651856

申请日：2017-07-17

Applicant: Karyopharm Therapeutics Inc.

Inventor： Erkan Baloglu ,  Sharon Shacham ,  Dilara McCauley ,  Trinayan Kashyap ,  William Senapedis ,  Yosef Landesman ,  Gali Golan ,  Ori Kalid ,  Sharon Shechter

IPC: A61K31/4196 ,  C07D249/08 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06

Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I or their pharmaceutically acceptable salts, and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.

公开(公告)号：US20220177445A1

公开(公告)日：2022-06-09

申请号：US17409150

申请日：2021-08-23

Applicant: Karyopharm Therapeutics Inc.

Inventor： Erkan Baloglu ,  Sharon Shacham ,  Dilara McCauley ,  Trinayan Kashyap ,  William Senapedis ,  Yosef Landesman ,  Gali Golan ,  Ori Kalid ,  Sharon Shechter

IPC: C07D401/06 ,  C07D249/08 ,  C07D403/06 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06

Abstract: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I or their pharmaceutically acceptable salts, and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.

公开(公告)号：US20160152596A1

公开(公告)日：2016-06-02

申请号：US14900469

申请日：2014-06-20

Applicant: KARYOPHARM THERAPEUTICS INC.

Inventor： Erkan Baloglu ,  Sharon Shacham ,  Dilara McCauley ,  Trinayan Kashyap ,  William Senapedis ,  Yosef Landesman ,  Gali Golan ,  Ori Kalid ,  Sharon Shechter

IPC: C07D401/06 ,  C07D249/08 ,  C07D413/06 ,  C07D405/06 ,  C07D417/06 ,  C07D403/06

CPC classification number: C07D401/06 ,  C07D249/08 ,  C07D403/06 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06

Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula (I) or their pharmaceutically acceptable salts, and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.

Abstract translation: 本发明涉及式（I）化合物及其药学上可接受的盐，包含式（I）化合物或其药学上可接受的盐的药物组合物，以及使用所述化合物，盐和组合物治疗各种疾病的方法 与CRM1活动相关。