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1.
公开(公告)号:US20160221994A1
公开(公告)日:2016-08-04
申请号:US14647662
申请日:2013-11-27
发明人: Erkan Baloglu , Sharon Shechter , Sharon Shacham , Dilara McCauley , William Senapedis , Gali Golan , Ori Kalid
IPC分类号: C07D405/12 , C07D413/14 , C07D495/04 , C07D409/12 , C07D417/14 , C07D409/14 , C07D409/04
CPC分类号: C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D495/04
摘要: The invention generally relates to substituted 2,3-dihydrobenzofuranyl compounds, and more particularly to a compound represented by Structural Formula (I), or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula (I), or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.
摘要翻译: 本发明一般涉及取代的2,3-二氢苯并呋喃基化合物,特别是涉及由结构式(I)表示的化合物或其药学上可接受的盐,其中变量如本文所定义和描述。 本发明还包括结构式(I)的化合物或其药学上可接受的盐或组合物的合成和用途,例如用于治疗癌症(例如,套细胞淋巴瘤)和其它疾病和病症。
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公开(公告)号:US09994558B2
公开(公告)日:2018-06-12
申请号:US15023269
申请日:2014-09-19
发明人: Erkan Baloglu , Sharon Shacham , William Senapedis , Dilara McCauley , Yosef Landesman , Gali Golan , Ori Kalid , Sharon Shechter
IPC分类号: C07D213/73 , C07D401/12 , C07D409/14 , A61K31/433 , C07D409/12 , C07D213/81 , C07D413/12
CPC分类号: C07D409/12 , C07D213/73 , C07D213/81 , C07D401/12 , C07D401/14 , C07D409/14 , C07D413/12 , C07D417/12 , C07D419/12
摘要: The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).
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公开(公告)号:US20180155317A1
公开(公告)日:2018-06-07
申请号:US15651856
申请日:2017-07-17
发明人: Erkan Baloglu , Sharon Shacham , Dilara McCauley , Trinayan Kashyap , William Senapedis , Yosef Landesman , Gali Golan , Ori Kalid , Sharon Shechter
IPC分类号: C07D401/06 , C07D403/06 , C07D405/06 , C07D413/06 , C07D417/06 , C07D249/08
CPC分类号: C07D401/06 , C07D249/08 , C07D403/06 , C07D405/06 , C07D413/06 , C07D417/06
摘要: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I or their pharmaceutically acceptable salts, and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.
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4.
公开(公告)号:US20160368904A1
公开(公告)日:2016-12-22
申请号:US14902202
申请日:2014-07-03
发明人: Erkan Baloglu , Sharon Shacham , William Senapedis , Dilara McCauley , Yosef Landesman , Gali Golan , Ori Kalid , Sharon Shechter
IPC分类号: C07D405/14 , C07D307/81 , C07D409/14 , C07D491/048 , C07D413/14 , C07D417/12 , C07D491/08 , C07D405/12 , C07D413/12
CPC分类号: C07D405/14 , C07D307/81 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D491/048 , C07D491/08
摘要: The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula (A), or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.
摘要翻译: 本发明一般涉及取代的苯并呋喃基和取代的苯并恶唑基化合物,更具体地涉及由结构式(A)表示的化合物或其药学上可接受的盐,其中变量如本文所定义和描述。 本发明还包括结构式(A)的化合物或其药学上可接受的盐或组合物的合成和用途,例如用于治疗癌症(例如,外套细胞淋巴瘤)和其它疾病和病症。
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公开(公告)号:US11124493B2
公开(公告)日:2021-09-21
申请号:US16519955
申请日:2019-07-23
发明人: Erkan Baloglu , Sharon Shacham , Dilara McCauley , Trinayan Kashyap , William Senapedis , Yosef Landesman , Gali Golan , Ori Kalid , Sharon Shechter
IPC分类号: A61K31/506 , A61P35/00 , C07D403/06 , C07D401/06 , C07D249/08 , C07D405/06 , C07D413/06 , C07D417/06
摘要: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I or their pharmaceutically acceptable salts, and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.
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公开(公告)号:US10407405B2
公开(公告)日:2019-09-10
申请号:US15651856
申请日:2017-07-17
发明人: Erkan Baloglu , Sharon Shacham , Dilara McCauley , Trinayan Kashyap , William Senapedis , Yosef Landesman , Gali Golan , Ori Kalid , Sharon Shechter
IPC分类号: A61K31/4196 , C07D249/08 , C07D401/06 , C07D403/06 , C07D405/06 , C07D413/06 , C07D417/06
摘要: The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I or their pharmaceutically acceptable salts, and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.
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公开(公告)号:US09856241B2
公开(公告)日:2018-01-02
申请号:US14902202
申请日:2014-07-03
发明人: Erkan Baloglu , Sharon Shacham , William Senapedis , Dilara McCauley , Yosef Landesman , Gali Golan , Ori Kalid , Sharon Shechter
IPC分类号: C07D405/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D307/81 , C07D413/14 , C07D491/048 , C07D491/08
CPC分类号: C07D405/14 , C07D307/81 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D491/048 , C07D491/08
摘要: The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula (A), or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.
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公开(公告)号:US11008309B2
公开(公告)日:2021-05-18
申请号:US16507927
申请日:2019-07-10
发明人: Erkan Baloglu , Sharon Shacham , William Senapedis , Dilara McCauley , Yosef Landesman , Gali Golan , Ori Kalid , Sharon Shechter
IPC分类号: C07D405/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D307/81 , C07D413/14 , C07D491/048 , C07D491/08
摘要: The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula A: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula A, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.
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公开(公告)号:US10399963B2
公开(公告)日:2019-09-03
申请号:US15831111
申请日:2017-12-04
发明人: Erkan Baloglu , Sharon Shacham , William Senapedis , Dilara McCauley , Yosef Landesman , Gali Golan , Ori Kalid , Sharon Shechter
IPC分类号: C07D405/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D307/81 , C07D413/14 , C07D491/048 , C07D491/08
摘要: The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula A: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula A, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.
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公开(公告)号:US09938258B2
公开(公告)日:2018-04-10
申请号:US14647662
申请日:2013-11-27
发明人: Erkan Baloglu , Sharon Shechter , Sharon Shacham , Dilara McCauley , William Senapedis , Gali Golan , Ori Kalid
IPC分类号: C07D405/12 , C07D413/14 , C07D495/04 , C07D409/12 , C07D417/14 , C07D409/14 , C07D409/04 , C07D405/14
CPC分类号: C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D495/04
摘要: The invention generally relates to substituted 2,3-dihydrobenzofuranyl compounds, and more particularly to a compound represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.
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