公开(公告)号：US20210106644A1

公开(公告)日：2021-04-15

申请号：US17023447

申请日：2020-09-17

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyoung Ja KIM ,  Chang Bae JIN ,  Hyun Beom LEE ,  Hyun Soo CHOI ,  You Bin CHO

IPC: A61K36/73 ,  C07H15/24 ,  A61K9/00

Abstract: Disclosed are a Filipendula glaberrima alcoholic extract and solvent fractions fractionated therefrom or novel compounds 1 and 2 purely isolated from a Filipendula glaberrima ethyl acetate fraction that have an excellent inhibitory effect against HMG-CoA reductase activity, an excellent antioxidant effect and a remarkably excellent effect of suppressing the formation of foam cells in macrophages. Also, disclosed is a pharmaceutical composition or health food composition for treating, preventing and ameliorating vascular diseases, hypercholesterolemia, or heart diseases caused by hypercholesterolemia, or lowering blood cholesterol levels, containing, as active ingredients, the Filipendula glaberrima alcoholic extract and the solvent fractions or the novel compounds 1 and 2.

公开(公告)号：US20210393722A1

公开(公告)日：2021-12-23

申请号：US17288632

申请日：2019-10-31

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hong Seog SEO ,  Yong Jik LEE ,  Hyoung Ja KIM ,  Chang Bae JIN

IPC: A61K36/28 ,  A61K31/216 ,  A23L33/10

Abstract: The present invention relates to a composition for improving skin barrier damage and/or alleviating skin inflammation, wherein 3,5-dicaffeoylquinic acid isolated from an Aster glehni (AG) extract is introduced as an active ingredient of a cosmetic composition or a pharmaceutical composition for improving skim barrier damage and alleviating skin inflammation, thereby being effective in preventing and improving atopic dermatitis.

公开(公告)号：US20210113640A1

公开(公告)日：2021-04-22

申请号：US17035391

申请日：2020-09-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyoung Ja KIM ,  Chang Bae JIN ,  Seon Hee SEO

IPC: A61K36/28 ,  A61P17/14 ,  A61Q7/00 ,  A61K8/9789

Abstract: Disclosed is a composition for promoting hair growth or preventing hair loss containing an Aster ageratoides alcohol extract or a solvent fraction obtained through fractionation therefrom as an active ingredient. The composition for promoting hair growth or preventing hair loss has excellent effects of inducing hair growth in a growth phase, preventing hair loss in a catagen phase and proliferating skin cells, and is thus capable of effectively overcoming a variety of problems caused by hair-growth promotion agents or hair-loss prevention agents.

公开(公告)号：US20150337001A1

公开(公告)日：2015-11-26

申请号：US14717016

申请日：2015-05-20

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyoung Ja KIM ,  Chang Bae JIN ,  Min Jeoung SON ,  Yong Sup LEE ,  Chang Soo YOOK ,  Jae Yeol LEE

IPC: C07H15/207 ,  A23L1/30 ,  A61K36/28

CPC classification number: C07H15/207 ,  A23L33/105 ,  A61K31/704 ,  A61K36/28 ,  A61K2236/00 ,  C07H15/10 ,  C07H15/18

Abstract: The present invention relates to an Aster glehni extract, a fraction thereof and the active compounds isolated therefrom, which are effective for the treatment, prevention and improvement of hyperuricemia or gout. The Aster glehni extract, the fraction thereof and 6′-O-caffeoylampelopsisionoside, 6′-O-caffeoylroseoside, 6′-O-caffeoylsonchuinoside C, 6′-O-caffeoyldihydrosyringin and glehnoside as the active compounds isolated from the fraction according to the present invention have substantial effect of inhibiting production of uric acid and decreasing its concentration. Accordingly, the Aster glehni extract, the fraction thereof and the active compounds isolated therefrom the fraction according to the present invention can be effectively used as an active ingredient of a drug, health food, etc. for the treatment, prevention and improvement of such as hyperuricemia or gout, which are diseases induced by increased level of uric acid.

Abstract translation: 本发明涉及一种有效治疗，预防和改善高尿酸血症或痛风的阿斯特氏提取物及其分离物及其分离的活性化合物。 Aster glehni提取物，其分数和6'-O-咖啡酰罂粟苷苷，6'-O-咖啡酰基糖苷，6'-O-咖啡酰基胆碱酯C，6'-O-咖啡酰二氢肉豆蔻苷和格列本苷作为从根据 本发明具有抑制尿酸生成和降低其浓度的显着效果。 因此，可以有效地使用根据本发明的级分的分解的Aster glehni提取物及其分离的活性化合物作为药物，保健食品等的活性成分，用于治疗，预防和改善诸如 高尿酸血症或痛风是由尿酸水平升高引起的疾病。