公开(公告)号：US20240216462A1

公开(公告)日：2024-07-04

申请号：US18530106

申请日：2023-12-05

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jaeyoung KWON ,  Hak Cheol Kwon ,  Won Kyu Kim ,  Choong-Gu Lee ,  InWha Park ,  Hyeon-Seong Lee ,  Sungmin Song ,  Hoseong Hwang ,  Soon Kwang Lee ,  Jong Gwon Baek ,  Dong Hoon Kim ,  Yujin Kwon ,  Su-Yeon Cho ,  Dae Sik Jang

IPC: A61K36/68 ,  A61K31/7034 ,  A61K31/7048

CPC classification number: A61K36/68 ,  A61K31/7034 ,  A61K31/7048 ,  A61K2236/333 ,  A61K2236/39

Abstract: The present disclosure is completed by confirming the differentiation into Th17 and its activity-increasing function and the differentiation into Treg and its activity-suppressing function in compounds isolated from Pseudolysimachion nakaianum (Ohwi) T. Yamaz. The composition of the present disclosure increases the immune response by simultaneously regulating Th17 and Treg cell groups and their activities, and thus may be applied for the prevention and treatment of cancer and infectious diseases. According to the present disclosure, there is an advantage of having very few or no side effects by using Pseudolysimachion nakaianum (Ohwi) T. Yamaz, a natural product with safety that has been verified for a long time. Therefore, the present disclosure is expected to be used in various fields such as drugs, quasi-drugs, cosmetic materials, functional biomaterials, and functional food materials for immunity reinforcement and improvement, prevention, or treatment of infectious diseases and tumors.

公开(公告)号：US12201664B2

公开(公告)日：2025-01-21

申请号：US17059595

申请日：2019-05-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyun Ok Yang ,  Keon Wook Kang ,  Sung Won Kwon ,  Jeong Hill Park ,  Hocheol Kim ,  Myung Sook Oh ,  Dae Sik Jang ,  Doheon Lee ,  Hak Cheol Kwon ,  Byung Hwa Jung

IPC: A61K36/54 ,  A61K36/268 ,  A61K36/346 ,  A23K10/30 ,  A23L33/105

Abstract: The present invention relates to a pharmaceutical composition for prevention or treatment of an allergic disease comprising a mixed extract of two or more selected from the group consisting of Asiasarum root, Platycodon root, and Cinnamomi ramulus as an active ingredient; a method for prevention or treatment of an allergic disease using the pharmaceutical composition; and a health functional food and a feed composition for improvement of an allergic disease. The composition and method of the invention can specifically inhibit the differentiation of Th2 cells and thus can be effectively used as a composition for prevention or treatment of an allergic disease.