公开(公告)号：US20200342957A1

公开(公告)日：2020-10-29

申请号：US16857765

申请日：2020-04-24

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Keunwan PARK ,  Cheol-Ho PAN ,  Young-Joon KO ,  Prasannavenkatesh DURAI ,  Yongsoo CHOI ,  Moon-Hyeong SEO ,  Kyungsu KANG ,  Jin Soo PARK ,  Jaeyoung KWON

IPC: G16B20/30 ,  G16B40/20 ,  G16B15/30

Abstract: The present invention relates to an ensemble evolutionary chemical binding similarity (ensECBS) model, which is a chemical binding similarity searching method widely applicable as a powerful tool for representing an unknown relationship between chemicals by using evolutionary information of proteins binding to chemicals.

公开(公告)号：US20230109869A1

公开(公告)日：2023-04-13

申请号：US17962092

申请日：2022-10-07

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

Inventor： Hak Cheol KWON ,  Jaeyoung KWON ,  Seong-Hwan KIM ,  Jung Hwan LEE ,  Jin Wook CHA ,  Ho Seong HWANG ,  Won Kyu KIM ,  Yujin KWON ,  Suyeon CHO ,  Taek Joo LEE ,  Jung Hwa KANG ,  Wan Hee LEE ,  Hyunki KIM

IPC: A61K36/268 ,  A61K36/73 ,  A61P35/00 ,  A61P1/00 ,  A23L33/105 ,  A23L33/00 ,  A23K10/30

Abstract: Provided are compositions for preventing or treating cancer including Asarum maculatum Nakai extracts, or a fraction thereof. According to an aspect, an Asarum maculatum Nakai extract has an excellent anticancer efficacy against various cancers including diffuse-type gastric cancer, and a cancer treatment agent having an excellent effect may be developed by using the extract as an active ingredient.

公开(公告)号：US20180085414A1

公开(公告)日：2018-03-29

申请号：US15717337

申请日：2017-09-27

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Chu Won NHO ,  Hak Cheol KWON ,  Ji-Hye YOO ,  Jaeyoung KWON ,  Jin Soo PARK ,  Hyuk-Jai JANG ,  Seong-Su KIM ,  Cheon Soo PARK ,  Hwa-Mi LEE ,  Hee Ju LEE

IPC: A61K36/28 ,  A23L33/105 ,  A23L33/00

CPC classification number: A61K36/28 ,  A23L33/105 ,  A23L33/30 ,  A23L33/40 ,  A23V2002/00 ,  A61P9/10

Abstract: Provided are a pharmaceutical composition including a Crepidiastrum denticulatum extract as an active ingredient; and a method for preventing or treating ischemia-reperfusion injury in a subject by using a food composition or the pharmaceutical composition.

公开(公告)号：US20240216462A1

公开(公告)日：2024-07-04

申请号：US18530106

申请日：2023-12-05

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Jaeyoung KWON ,  Hak Cheol Kwon ,  Won Kyu Kim ,  Choong-Gu Lee ,  InWha Park ,  Hyeon-Seong Lee ,  Sungmin Song ,  Hoseong Hwang ,  Soon Kwang Lee ,  Jong Gwon Baek ,  Dong Hoon Kim ,  Yujin Kwon ,  Su-Yeon Cho ,  Dae Sik Jang

IPC: A61K36/68 ,  A61K31/7034 ,  A61K31/7048

CPC classification number: A61K36/68 ,  A61K31/7034 ,  A61K31/7048 ,  A61K2236/333 ,  A61K2236/39

Abstract: The present disclosure is completed by confirming the differentiation into Th17 and its activity-increasing function and the differentiation into Treg and its activity-suppressing function in compounds isolated from Pseudolysimachion nakaianum (Ohwi) T. Yamaz. The composition of the present disclosure increases the immune response by simultaneously regulating Th17 and Treg cell groups and their activities, and thus may be applied for the prevention and treatment of cancer and infectious diseases. According to the present disclosure, there is an advantage of having very few or no side effects by using Pseudolysimachion nakaianum (Ohwi) T. Yamaz, a natural product with safety that has been verified for a long time. Therefore, the present disclosure is expected to be used in various fields such as drugs, quasi-drugs, cosmetic materials, functional biomaterials, and functional food materials for immunity reinforcement and improvement, prevention, or treatment of infectious diseases and tumors.

公开(公告)号：US20210284677A1

公开(公告)日：2021-09-16

申请号：US17199651

申请日：2021-03-12

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hyun Ok YANG ,  Hak Cheol KWON ,  Li Jun ZHANG ,  Jaeyoung KWON ,  Kee Beom KO

IPC: C07H15/24 ,  A61P25/28 ,  A61K9/00 ,  A23L33/105 ,  A23L33/00

Abstract: Provided are astersaponin I, which is a novel triterpene saponin derivative isolated and identified from a Aster koraiensis Nakai (Korean starwort) extract, and a use thereof for preventing or treating a neurodegenerative disorder.

公开(公告)号：US20230114565A1

公开(公告)日：2023-04-13

申请号：US17962026

申请日：2022-10-07

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY

Inventor： Hak Cheol KWON ,  Jaeyoung KWON ,  Seong-Hwan KIM ,  Jin Wook CHA ,  Soon Kwang LEE ,  Won Kyu KIM ,  Yujin KWON ,  Suyeon CHO ,  Taek Joo LEE ,  Jung Hwa KANG ,  Wan Hee LEE ,  Hyunki KIM

IPC: A61K36/73 ,  A61K36/268 ,  A61P35/00 ,  A61P1/00

Abstract: Provided are compositions for preventing or treating cancer, the compositions including Rubus longisepalus var. tozawai (Nakai) T.B.Lee extracts, or a fraction thereof as an active ingredient.
According to an aspect, a Rubus longisepalus var. tozawai (Nakai) T.B.Lee extract has an excellent anticancer efficacy against various cancers including diffuse-type gastric cancer, and thus, a cancer treatment agent having an excellent effect may be developed by using the extract as an active ingredient.

公开(公告)号：US20190381122A1

公开(公告)日：2019-12-19

申请号：US16555950

申请日：2019-08-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Chu Won NHO ,  Hak Cheol KWON ,  Ji-Hye YOO ,  Jaeyoung KWON ,  Jin Soo PARK ,  Hyuk-Jai JANG ,  Seong-Su KIM ,  Cheon Soo PARK ,  Hwa-Mi LEE ,  Hee Ju LEE

IPC: A61K36/28 ,  A23L33/00 ,  A23L33/105

Abstract: Provided are a pharmaceutical composition including a Crepidiastrum denticulatum extract as an active ingredient; and a method for preventing or treating ischemia-reperfusion injury in a subject by using a food composition or the pharmaceutical composition.