公开(公告)号：US20140140934A1

公开(公告)日：2014-05-22

申请号：US14074865

申请日：2013-11-08

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kwang Meyung Kim ,  Ick Chan Kwon ,  Inchan Youn ,  Hyun Su Min ,  Hong Yeol Yoon ,  Jae Hyung Park

IPC: A61K49/22

CPC classification number: A61K49/223 ,  A61K49/0032 ,  A61K49/0069

Abstract: Disclosed is a liver tumor-targeting ultrasound contrast agent. The ultrasound contrast agent includes a gas-generating core and a hyaluronic acid shell. The ultrasound contrast agent can be specifically delivered to liver cells. This specific delivery enables easy differentiation between normal liver cells and liver tumor cells by ultrasound imaging. In addition, the ultrasound contrast agent is highly stable in aqueous condition and causes no cytotoxicity. Also disclosed is a method for preparing the ultrasound contrast agent.

Abstract translation: 公开了一种肝肿瘤靶向超声造影剂。 超声造影剂包括产气芯和透明质酸壳。 可以将超声造影剂特异性地递送至肝细胞。 这种特异性的传递使得通过超声成像能够容易地在正常肝细胞和肝肿瘤细胞之间进行分化。 此外，超声造影剂在水性条件下高度稳定，不产生细胞毒性。 还公开了一种制备超声造影剂的方法。

公开(公告)号：US09259493B2

公开(公告)日：2016-02-16

申请号：US14074865

申请日：2013-11-08

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kwang Meyung Kim ,  Ick Chan Kwon ,  Inchan Youn ,  Hyun Su Min ,  Hong Yeol Yoon ,  Jae Hyung Park

IPC: A61K49/22 ,  A61K49/00

CPC classification number: A61K49/223 ,  A61K49/0032 ,  A61K49/0069

Abstract: Disclosed is a liver tumor-targeting ultrasound contrast agent. The ultrasound contrast agent includes a gas-generating core and a hyaluronic acid shell. The ultrasound contrast agent can be specifically delivered to liver cells. This specific delivery enables easy differentiation between normal liver cells and liver tumor cells by ultrasound imaging. In addition, the ultrasound contrast agent is highly stable in aqueous condition and causes no cytotoxicity. Also disclosed is a method for preparing the ultrasound contrast agent.

Abstract translation: 公开了一种肝肿瘤靶向超声造影剂。 超声造影剂包括产气芯和透明质酸壳。 可以将超声造影剂特异性地递送至肝细胞。 这种特异性的传递使得通过超声成像容易地在正常肝细胞和肝肿瘤细胞之间分化。 此外，超声造影剂在水性条件下高度稳定，不产生细胞毒性。 还公开了一种制备超声造影剂的方法。