-
1.发明授权公开(公告)号：US09259493B2
公开(公告)日：2016-02-16
申请号：US14074865
申请日：2013-11-08
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Kwang Meyung Kim , Ick Chan Kwon , Inchan Youn , Hyun Su Min , Hong Yeol Yoon , Jae Hyung Park
CPC classification number: A61K49/223 , A61K49/0032 , A61K49/0069
Abstract: Disclosed is a liver tumor-targeting ultrasound contrast agent. The ultrasound contrast agent includes a gas-generating core and a hyaluronic acid shell. The ultrasound contrast agent can be specifically delivered to liver cells. This specific delivery enables easy differentiation between normal liver cells and liver tumor cells by ultrasound imaging. In addition, the ultrasound contrast agent is highly stable in aqueous condition and causes no cytotoxicity. Also disclosed is a method for preparing the ultrasound contrast agent.
Abstract translation: 公开了一种肝肿瘤靶向超声造影剂。 超声造影剂包括产气芯和透明质酸壳。 可以将超声造影剂特异性地递送至肝细胞。 这种特异性的传递使得通过超声成像容易地在正常肝细胞和肝肿瘤细胞之间分化。 此外，超声造影剂在水性条件下高度稳定，不产生细胞毒性。 还公开了一种制备超声造影剂的方法。
-
2.发明授权Tumor-targeting gas-generating nanoparticle, method for preparing the same, and tumor-targeting nanoparticle for drug delivery using the same 有权肿瘤靶向产生气体的纳米颗粒，其制备方法和用于药物递送的肿瘤靶向纳米颗粒公开(公告)号：US09259395B2
公开(公告)日：2016-02-16
申请号：US13906963
申请日：2013-05-31
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Ick Chan Kwon , Kwang Meyung Kim , Kuiwon Choi , Heebeom Koo , Hyun Su Min , Inchan Youn
CPC classification number: A61K9/5146 , A61K9/0004 , A61K9/0009 , A61K9/0019 , A61K9/5153 , A61K41/0028 , A61K47/6925 , A61K49/0032 , A61K49/0054 , A61K49/0093 , A61K49/222 , A61K49/225
Abstract: A tumor-targeting gas-generating nanoparticle, a method for preparing same and a tumor-targeting nanoparticle for drug delivery using same relate to a tumor-targeting gas-generating nanoparticle including a polycarbonate core and a amphiphilic coat, a method for preparing same and a tumor-targeting nanoparticle for drug delivery using same. Since a tumor-targeting gas-generating nanoparticle according to the present disclosure is accumulated in the tumor tissue in large quantity and generates strong ultrasound wave signals, it can be usefully used as a contrast agent for ultrasonic imaging.
Abstract translation: 肿瘤靶向产生气体的纳米颗粒，其制备方法和使用其的药物递送的肿瘤靶向纳米颗粒涉及包含聚碳酸酯芯和两亲性涂层的肿瘤靶向产生气体的纳米颗粒，其制备方法和 用于药物递送的肿瘤靶向纳米颗粒。 由于根据本发明的肿瘤靶向产生气体的纳米颗粒大量积聚在肿瘤组织中，并且产生强大的超声波信号，因此可以有效地用作超声成像造影剂。
-
3.发明申请CT Contrast Medium for Detecting Thrombus, Comprising Fibrin-Targeted Peptide Sequence-Conjugated Glycol Chitosan-Gold Nanoparticles 有权用于检测血栓的CT对比介质，包括纤维蛋白靶向肽序列 - 缀合的乙二醇壳聚糖 - 金纳米颗粒公开(公告)号：US20150139912A1
公开(公告)日：2015-05-21
申请号：US14402214
申请日：2013-05-13
Applicant: DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION F FOUNDATION , SNU R&DB FOUNDATION , KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Dong Eog Kim , Jeong Yeon Kim , In Cheol Sun , Sung Kyung Park , Cheol Hee Ahn , Kwang Meyung Kim
CPC classification number: A61K49/04 , A61K49/0428 , B82Y5/00 , G06T11/003
Abstract: The present invention relates to a CT contrast agent for detecting a thrombus, comprising fibrin-targeted peptide sequence-conjugated glycol chitosan-gold nanoparticles. The CT contrast agent for detecting a thrombus according to an embodiment of the present invention may allow rapid and repeated acquisition of CT image information related to the size and location of a thrombus in cardio-cerebral vascular thrombosis, and also enables the imaging monitoring of cerebral thrombus.
Abstract translation: 本发明涉及用于检测血栓的CT造影剂，其包含纤维蛋白靶向肽序列 - 共轭二醇壳聚糖 - 金纳米粒子。 根据本发明的实施方案的用于检测血栓的CT造影剂可以允许快速和重复地获取与心血管血栓形成中血栓的大小和位置相关的CT图像信息，并且还能够进行脑的成像监测 血栓。
-
4.发明申请公开(公告)号：US20140140934A1
公开(公告)日：2014-05-22
申请号：US14074865
申请日：2013-11-08
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Kwang Meyung Kim , Ick Chan Kwon , Inchan Youn , Hyun Su Min , Hong Yeol Yoon , Jae Hyung Park
IPC: A61K49/22
CPC classification number: A61K49/223 , A61K49/0032 , A61K49/0069
Abstract: Disclosed is a liver tumor-targeting ultrasound contrast agent. The ultrasound contrast agent includes a gas-generating core and a hyaluronic acid shell. The ultrasound contrast agent can be specifically delivered to liver cells. This specific delivery enables easy differentiation between normal liver cells and liver tumor cells by ultrasound imaging. In addition, the ultrasound contrast agent is highly stable in aqueous condition and causes no cytotoxicity. Also disclosed is a method for preparing the ultrasound contrast agent.
Abstract translation: 公开了一种肝肿瘤靶向超声造影剂。 超声造影剂包括产气芯和透明质酸壳。 可以将超声造影剂特异性地递送至肝细胞。 这种特异性的传递使得通过超声成像能够容易地在正常肝细胞和肝肿瘤细胞之间进行分化。 此外，超声造影剂在水性条件下高度稳定，不产生细胞毒性。 还公开了一种制备超声造影剂的方法。
-
Patent Agency Ranking
5.发明申请TUMOR-TARGETING GAS-GENERATING NANOPARTICLE, METHOD FOR PREPARING THE SAME, AND TUMOR-TARGETING NANOPARTICLE FOR DRUG DELIVERY USING THE SAME 有权肿瘤靶向气体产生纳米颗粒，其制备方法和用于药物递送的肿瘤靶向纳米颗粒公开(公告)号：US20130323177A1
公开(公告)日：2013-12-05
申请号：US13906963
申请日：2013-05-31
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Ick Chan Kwon , Kwang Meyung Kim , Kuiwon Choi , Heebeom Koo , Hyun Su Min , Inchan Youn
CPC classification number: A61K9/5146 , A61K9/0004 , A61K9/0009 , A61K9/0019 , A61K9/5153 , A61K41/0028 , A61K47/6925 , A61K49/0032 , A61K49/0054 , A61K49/0093 , A61K49/222 , A61K49/225
Abstract: A tumor-targeting gas-generating nanoparticle, a method for preparing same and a tumor-targeting nanoparticle for drug delivery using same relate to a tumor-targeting gas-generating nanoparticle including a polycarbonate core and a amphiphilic coat, a method for preparing same and a tumor-targeting nanoparticle for drug delivery using same. Since a tumor-targeting gas-generating nanoparticle according to the present disclosure is accumulated in the tumor tissue in large quantity and generates strong ultrasound wave signals, it can be usefully used as a contrast agent for ultrasonic imaging.
Abstract translation: 肿瘤靶向产生气体的纳米颗粒，其制备方法和使用其的药物递送的肿瘤靶向纳米颗粒涉及包含聚碳酸酯芯和两亲性涂层的肿瘤靶向产生气体的纳米颗粒，其制备方法和 用于药物递送的肿瘤靶向纳米颗粒。 由于根据本发明的肿瘤靶向产生气体的纳米颗粒大量积聚在肿瘤组织中，并且产生强大的超声波信号，因此可以有效地用作超声成像造影剂。
-
6.发明授权公开(公告)号：US09801943B2
公开(公告)日：2017-10-31
申请号：US13774247
申请日：2013-02-22
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Kwang Meyung Kim , Ick Chan Kwon , Kuiwon Choi , Heebeom Koo , Sang-min Lee , Inchan Youn
CPC classification number: A61K47/26 , A61K47/34 , A61K47/549 , A61K47/555 , A61K47/6911 , A61K49/0032 , A61K49/0052
Abstract: The present disclosure relates to a method for in vivo targeting of a nanoparticle via bioorthogonal copper-free click chemistry, more particularly to a method for in vivo targeting of a nanoparticle, including: injecting a precursor capable of being metabolically engineered in vivo when injected into a living system and having a first bioorthogonal functional group into the living system; and injecting a nanoparticle having a second bioorthogonal functional group which can perform a bioorthogonal copper-free click reaction with the first bioorthogonal functional group attached thereto into the living system.In accordance with the present disclosure, accumulation of nanoparticles at a target site in a living system can be increased remarkably and the biodistribution of the nanoparticles can be controlled since the nanoparticles bound to a cell surface are taken up into the cell with time.
-
公开(公告)号：US09717807B2
公开(公告)日：2017-08-01
申请号：US14402214
申请日：2013-05-13
Applicant: DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION , SNU R&DB FOUNDATION , KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Dong Eog Kim , Jeong Yeon Kim , In Cheol Sun , Sung Kyung Park , Cheol Hee Ahn , Kwang Meyung Kim
CPC classification number: A61K49/04 , A61K49/0428 , B82Y5/00 , G06T11/003
Abstract: The present invention relates to a CT contrast agent for detecting a thrombus, comprising fibrin-targeted peptide sequence-conjugated glycol chitosan-gold nanoparticles. The CT contrast agent for detecting a thrombus according to an embodiment of the present invention may allow rapid and repeated acquisition of CT image information related to the size and location of a thrombus in cardio-cerebral vascular thrombosis, and also enables the imaging monitoring of cerebral thrombus.
-
8.发明授权Gelatin-based nanoparticle complex for tumor-targeted delivery of siRNA and method for preparing the same 有权用于肿瘤靶向递送siRNA的明胶基纳米颗粒复合物及其制备方法公开(公告)号：US09415060B2
公开(公告)日：2016-08-16
申请号：US14340845
申请日：2014-07-25
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Kwang Meyung Kim , Sun Hwa Kim , Ick Chan Kwon , Ji Young Yhee , Sojin Lee
IPC: A61K47/48 , A61K31/7088 , A61K31/713
CPC classification number: A61K31/7088 , A61K31/713 , A61K47/6435 , A61K47/6903 , A61K47/6929
Abstract: Disclosed is a gelatin-based nanoparticle complex for tumor-targeted delivery of siRNA for specific gene silencing in tumor cells. The gelatin-based nanoparticle complex includes: poly-siRNA chains whose ends are modified with thiol groups; and thiolated gelatin bound to the poly-siRNA chains through disulfide crosslinking and charge interactions. The gelatin-based nanoparticle complex is not degraded in the bloodstream and can be efficiently absorbed into tumor cells without cytotoxicity. The delivered siRNA can effectively silence target gene expression. Also disclosed is a method for preparing the gelatin-based nanoparticle complex.
Abstract translation: 公开了一种用于肿瘤靶向递送siRNA用于肿瘤细胞中特异性基因沉默的明胶基纳米颗粒复合物。 基于明胶的纳米颗粒复合物包括：末端用巯基修饰的多siRNA链; 并通过二硫键交联和电荷相互作用将与siRNA结合的多聚siRNA链结合在一起。 基于明胶的纳米颗粒复合物在血液中不降解，并且可以有效地吸收到肿瘤细胞中而没有细胞毒性。 递送的siRNA可以有效地沉默靶基因表达。 还公开了一种制备明胶基纳米颗粒复合物的方法。
-
公开(公告)号：US09409923B2
公开(公告)日：2016-08-09
申请号：US13936768
申请日：2013-07-08
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： Kwang Meyung Kim , Ick Chan Kwon , Sang Yoon Kim , Ju Hee Ryu , Eun Sung Jun , In San Kim
IPC: C07D499/78 , C07D209/62 , C07D409/14 , C07D498/08
CPC classification number: C07D499/78 , C07D209/62 , C07D409/14 , C07D498/08
Abstract: Disclosed is a drug-fluorophore complex for specific detection of tumor cells. Specifically, the drug-fluorophore complex includes a tumor cell-targeting drug penetrating tumor cells and non-tumor cells at different rates or levels, and a fluorescent substance chemically bonded to the tumor cell-targeting drug. The drug-fluorophore complex enables specific imaging of tumor cells only with high accuracy in a very simple manner without causing cytotoxicity.
Abstract translation: 公开了用于特异性检测肿瘤细胞的药物 - 荧光团复合物。 具体地，药物 - 荧光团复合物包括以不同速率或水平渗透肿瘤细胞和非肿瘤细胞的肿瘤细胞靶向药物和与肿瘤细胞靶向药物化学键合的荧光物质。 药物荧光团复合物能够以非常简单的方式以高精度进行肿瘤细胞的特异性成像，而不引起细胞毒性。
-
-
-
-
-
-
-
-
Search Results
9
records
(took 0.044 seconds)
