公开(公告)号：US20230120564A1

公开(公告)日：2023-04-20

申请号：US17794314

申请日：2020-07-14

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Chan Sun PARK ,  Seung Hye CHOI ,  Han Na CHO ,  Sandip SENGUPTA ,  In Jae SHIN ,  Woo Young HUR ,  Jayprakash Narayan KUMAR

IPC: C07D471/04

Abstract: The present invention relates to a pyrido[[3,4-d]pyrimidine derivative compound showing excellent anti-proliferative efficacy against cancer cells, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, a production method therefor, a pharmaceutical composition for preventing, alleviating, or treating cancer metastasis and proliferative diseases containing the same as an active ingredient, and an anticancer composition for cancer cells. The compound exhibits excellent inhibitory activity and anti-proliferative efficacy against cancer cells, and thus the compound is useful not only for inhibiting cancer cells, but also for preventing cancer metastasis and proliferative diseases or for treating cancer.