公开(公告)号：US20190135765A1

公开(公告)日：2019-05-09

申请号：US16090072

申请日：2017-03-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY

Inventor： Tae Bo SIM ,  Woo Young HUR ,  Ho Jong YOON ,  Chi Man SONG ,  In Jae SHUN ,  Byeong Yun LIM ,  HanNa CHO ,  Seung Hye CHOI ,  Gu KONG ,  Jeong Yeon LEE

IPC: C07D239/42 ,  A61P35/00 ,  C07D405/12 ,  C07D409/12 ,  C07D403/12

Abstract: The present invention relates to a novel pyrimidine-4-carboxylic acid derivative having an anticancer activity, and the compound of the present invention is useful as a drug for treating and preventing tumor diseases.

公开(公告)号：US20180065969A1

公开(公告)日：2018-03-08

申请号：US15672987

申请日：2017-08-09

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Han Na CHO ,  Eun Hye JU ,  Woo Young HUR ,  Ho Jong YOON ,  Chi Man SONG

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The present invention provides a therapeutic agent of acute myeloid leukemia containing a 1,3,7-trisubstituted 3,4-dihydropyrimido[4,5-d]pyrimidine-2(1H)-one compound as an active ingredient, which has proliferation inhibitory activity for a human acute myeloid leukemia cell line OCI-AML3 having a NRAS mutant gene while having low inhibitory activity for wild type NRAS and has activity of inhibiting GCK and ACK1 protein kinases at the same time.

公开(公告)号：US20230027716A1

公开(公告)日：2023-01-26

申请号：US17770630

申请日：2020-10-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Seong Shick RYU ,  Yun Ju NAM ,  Woo Young HUR

IPC: C07D403/12 ,  C07D401/14 ,  C07D401/04 ,  C07D413/14 ,  C07D405/14 ,  A61P35/00

Abstract: The present invention relates to: a compound selected from among a novel pyridinyltriazine derivative having protein kinase inhibitory activity, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof; a method for preparing the compound; and a pharmaceutical composition which is for preventing, alleviating, or treating cancer and comprises the compound. A novel compound according to the present invention exhibits excellent inhibitory effects against FGFR, which is a major trigger of bladder cancer, endometrial cancer, etc., point mutations thereof, and various protein kinases other than FGFR involved in signal transduction, and is thus effective as an agent for preventing and treating abnormal cell growth diseases caused by such protein kinases.

公开(公告)号：US20180050036A1

公开(公告)日：2018-02-22

申请号：US15677742

申请日：2017-08-15

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Ho Jong YOON ,  Woo Young HUR ,  Yun Ju NAM ,  Hwan Geun CHOI

IPC: A61K31/506

CPC classification number: A61K31/506 ,  A61K31/519 ,  A61K31/5377

Abstract: The present invention relates to a therapeutic agent for chronic myelogenous leukemia with reduced drug-resistance and side-effects containing a 1,6-disubstituted indole compound.

公开(公告)号：US20250101023A1

公开(公告)日：2025-03-27

申请号：US18730491

申请日：2023-01-19

Applicant: IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY) ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Gu KONG ,  Ratnakar Reddy KUCHUKULLA ,  Su Min KIM ,  So Jeong MOON ,  Woo Young HUR ,  In Jeong HWANG

IPC: C07D473/34 ,  A61K31/52 ,  A61K31/5377 ,  A61P35/00 ,  C07D473/16 ,  C07D473/40

Abstract: The present invention relates to a heteroaryl derivative, a stereoisomer thereof, a hydrate thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient. The heteroaryl derivative of the present invention exhibits high inhibitory activity against overexpressed HER2, and thus, a pharmaceutical composition containing the same as an active ingredient can be usefully used for preventing or treating HER-2 positive cancer.

公开(公告)号：US20230263792A1

公开(公告)日：2023-08-24

申请号：US18006584

申请日：2021-07-30

Applicant: PHAROS IBIO CO., LTD ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Seung Hye CHOI ,  Han Na CHO ,  Woo Young HUR ,  Chi Man SONG ,  Ky Youb NAM ,  Jeong Hyeok YOON

IPC: A61K31/4535 ,  A61P35/02 ,  A61P29/00

CPC classification number: A61K31/4535 ,  A61P35/02 ,  A61P29/00

Abstract: The present invention relates to the use of a 2,3,5-substituted thiophene compound for the prevention, amelioration or treatment of mastocytosis. The 2,3,5-substituted thiophene compound has excellent inhibitory activity against the growth of mastocytosis cells and against an inflammatory response caused by mastocytosis, and thus may be effectively used for the prevention, amelioration or treatment of mastocytosis.

公开(公告)号：US20180065970A1

公开(公告)日：2018-03-08

申请号：US15674023

申请日：2017-08-10

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Woo Young HUR ,  Ho Jong YOON ,  Chi Man SONG ,  Eun Hye JU ,  Han na CHO ,  Hwan Geun CHOI

IPC: C07D487/04 ,  C07D401/14 ,  C07D403/14

CPC classification number: C07D487/04 ,  A61K31/519 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14

Abstract: The present invention provides a pharmaceutical composition, as an effective ingredient, a urea compound having a protein kinase inhibitory activity and containing a 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one skeleton, and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20160145240A1

公开(公告)日：2016-05-26

申请号：US14947204

申请日：2015-11-20

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Ho Jong YOON ,  Ji Hye YOON ,  Woo Young HUR ,  Eun Joo ROH ,  Yeon Ui KWAK

IPC: C07D403/04 ,  C07D471/04 ,  C07D487/04 ,  C07D401/14

CPC classification number: C07D403/04 ,  C07D401/14 ,  C07D471/04 ,  C07D487/04

Abstract: A heteroarylamine compound includes protein kinase inhibition activity, a pharmaceutically acceptable salt thereof and a pharmaceutical composition for preventing and treating a disease caused by abnormal cell growth, which contains the compound as an active ingredient.

Abstract translation: 杂芳基胺化合物包括蛋白激酶抑制活性，其药学上可接受的盐和用于预防和治疗由异常细胞生长引起的疾病的药物组合物，其含有该化合物作为活性成分。

公开(公告)号：US20230270733A1

公开(公告)日：2023-08-31

申请号：US18006582

申请日：2021-07-30

Applicant: PHAROS IBIO CO., LTD. ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Seung Hye CHOI ,  Han Na CHO ,  Nam Kyoung KIM ,  Woo Young HUR ,  Chi Man SONG ,  Ky Youb NAM ,  Jeong Hyeok YOON

IPC: A61K31/4535 ,  A23L33/10 ,  A61P35/00

CPC classification number: A61K31/4535 ,  A23L33/10 ,  A61P35/00

Abstract: The present invention relates to the use of a 2,3,5-substituted thiophene compound for the prevention, amelioration or treatment of gastrointestinal stromal tumor. The 2,3,5-substituted thiophene compound exhibits high inhibitory activity against the growth of gastrointestinal stromal tumor, and thus may be effectively used for the prevention, amelioration or treatment of gastrointestinal stromal tumor.

公开(公告)号：US20230120564A1

公开(公告)日：2023-04-20

申请号：US17794314

申请日：2020-07-14

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Chan Sun PARK ,  Seung Hye CHOI ,  Han Na CHO ,  Sandip SENGUPTA ,  In Jae SHIN ,  Woo Young HUR ,  Jayprakash Narayan KUMAR

IPC: C07D471/04

Abstract: The present invention relates to a pyrido[[3,4-d]pyrimidine derivative compound showing excellent anti-proliferative efficacy against cancer cells, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, a production method therefor, a pharmaceutical composition for preventing, alleviating, or treating cancer metastasis and proliferative diseases containing the same as an active ingredient, and an anticancer composition for cancer cells. The compound exhibits excellent inhibitory activity and anti-proliferative efficacy against cancer cells, and thus the compound is useful not only for inhibiting cancer cells, but also for preventing cancer metastasis and proliferative diseases or for treating cancer.