公开(公告)号：US20230263792A1

公开(公告)日：2023-08-24

申请号：US18006584

申请日：2021-07-30

Applicant: PHAROS IBIO CO., LTD ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Seung Hye CHOI ,  Han Na CHO ,  Woo Young HUR ,  Chi Man SONG ,  Ky Youb NAM ,  Jeong Hyeok YOON

IPC: A61K31/4535 ,  A61P35/02 ,  A61P29/00

CPC classification number: A61K31/4535 ,  A61P35/02 ,  A61P29/00

Abstract: The present invention relates to the use of a 2,3,5-substituted thiophene compound for the prevention, amelioration or treatment of mastocytosis. The 2,3,5-substituted thiophene compound has excellent inhibitory activity against the growth of mastocytosis cells and against an inflammatory response caused by mastocytosis, and thus may be effectively used for the prevention, amelioration or treatment of mastocytosis.

公开(公告)号：US20230270733A1

公开(公告)日：2023-08-31

申请号：US18006582

申请日：2021-07-30

Applicant: PHAROS IBIO CO., LTD. ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Seung Hye CHOI ,  Han Na CHO ,  Nam Kyoung KIM ,  Woo Young HUR ,  Chi Man SONG ,  Ky Youb NAM ,  Jeong Hyeok YOON

IPC: A61K31/4535 ,  A23L33/10 ,  A61P35/00

CPC classification number: A61K31/4535 ,  A23L33/10 ,  A61P35/00

Abstract: The present invention relates to the use of a 2,3,5-substituted thiophene compound for the prevention, amelioration or treatment of gastrointestinal stromal tumor. The 2,3,5-substituted thiophene compound exhibits high inhibitory activity against the growth of gastrointestinal stromal tumor, and thus may be effectively used for the prevention, amelioration or treatment of gastrointestinal stromal tumor.

公开(公告)号：US20230120564A1

公开(公告)日：2023-04-20

申请号：US17794314

申请日：2020-07-14

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Tae Bo SIM ,  Chan Sun PARK ,  Seung Hye CHOI ,  Han Na CHO ,  Sandip SENGUPTA ,  In Jae SHIN ,  Woo Young HUR ,  Jayprakash Narayan KUMAR

IPC: C07D471/04

Abstract: The present invention relates to a pyrido[[3,4-d]pyrimidine derivative compound showing excellent anti-proliferative efficacy against cancer cells, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, a production method therefor, a pharmaceutical composition for preventing, alleviating, or treating cancer metastasis and proliferative diseases containing the same as an active ingredient, and an anticancer composition for cancer cells. The compound exhibits excellent inhibitory activity and anti-proliferative efficacy against cancer cells, and thus the compound is useful not only for inhibiting cancer cells, but also for preventing cancer metastasis and proliferative diseases or for treating cancer.

公开(公告)号：US20220135559A1

公开(公告)日：2022-05-05

申请号：US17431591

申请日：2020-02-17

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： TAE BO SIM ,  Woo Young HUR ,  Chi Man SONG ,  Sandip SENGUPTA ,  Chan Sun PARK ,  Seung Hye CHOI ,  Han Na CHO ,  In Jae SHIN

IPC: C07D471/04

Abstract: The present disclosure relates to a pyrido[3,4-d]pyrimidin-8-one derivative compound exhibiting excellent anti-proliferative effects against cancer cells, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, a production method therefor, a pharmaceutical composition for preventing, alleviating or treating cancer metastasis and proliferative disease containing the same as an active ingredient, and an anticancer composition against cancer cells. The compound exhibits excellent cancer cell inhibitory activity and anti-proliferative effects, and thus is effective in inhibiting cancer cells, preventing cancer metastasis and proliferative diseases or treating cancer.

公开(公告)号：US20190135765A1

公开(公告)日：2019-05-09

申请号：US16090072

申请日：2017-03-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY

Inventor： Tae Bo SIM ,  Woo Young HUR ,  Ho Jong YOON ,  Chi Man SONG ,  In Jae SHUN ,  Byeong Yun LIM ,  HanNa CHO ,  Seung Hye CHOI ,  Gu KONG ,  Jeong Yeon LEE

IPC: C07D239/42 ,  A61P35/00 ,  C07D405/12 ,  C07D409/12 ,  C07D403/12

Abstract: The present invention relates to a novel pyrimidine-4-carboxylic acid derivative having an anticancer activity, and the compound of the present invention is useful as a drug for treating and preventing tumor diseases.