公开(公告)号：US20190041357A1

公开(公告)日：2019-02-07

申请号：US16077074

申请日：2016-11-09

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kyoseon HWANG ,  Jinsik KIM ,  Hye Jin KIM ,  Yong Kyoung YOO ,  Youngsoo KIM

IPC: G01N27/447 ,  B03C5/00 ,  G01N33/543

Abstract: The present disclosure relates to an interdigitated electrode biosensor using dielectrophoresis, including an insulating layer configured to fully cover a sensor forming region of a substrate, a first interdigitated microelectrode configured such that a plurality of first protruding electrodes is arranged in a shape of a comb on the substrate, a second interdigitated microelectrode configured such that a plurality of second protruding electrodes is arranged in a shape of a comb and each interdigitates with the plurality of first protruding electrodes formed in the first interdigitated microelectrode, and a plurality of receptors that is immobilized in a space between the first interdigitated microelectrode and the second interdigitated microelectrode and reacts specifically to target biomaterials, wherein different voltages are uniformly or nonuniformly applied to the first interdigitated microelectrode and the second interdigitated microelectrode to generate a dielectrophoretic force by a nonuniform electric field, and thus there are effects in improving the sensitivity and the detection width of the sensor by increasing the probability of specific reaction with the target biomaterials using the concentration effect through dielectrophoresis.

公开(公告)号：US20170227482A1

公开(公告)日：2017-08-10

申请号：US15105740

申请日：2016-03-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kyoseon HWANG ,  Nakwon CHOI ,  Jinsik KIM ,  Hye Jin KIM ,  Yong Kyoung YOO ,  Sang Yun YEOM ,  Woongsun CHOI

IPC: G01N27/12 ,  G01N33/487 ,  G01N33/543

CPC classification number: G01N27/125 ,  G01N27/12 ,  G01N27/128 ,  G01N33/483 ,  G01N33/48707 ,  G01N33/53 ,  G01N33/54306 ,  G01N33/5438

Abstract: A hydrogel-based interdigitated microelectrode biosensor is disclosed. The hydrogel-based interdigitated microelectrode biosensor includes: a first interdigitated microelectrode having a plurality of first protrusion electrodes arranged in a comb-like shape on a substrate; a second interdigitated microelectrode facing the first interdigitated microelectrode and having a plurality of second protrusion electrodes arranged in a comb-like shape on the substrate, the second protrusion electrodes being arranged alternately with the first protrusion electrodes of the first interdigitated microelectrode; and a hydrogel filled in a space between the first and second interdigitated microelectrodes arranged alternately with each other. The hydrogel is provided between the interdigitated microelectrodes such that the presence and concentration of a biological substance, such as a protein, are detected by measuring the impedance between the interdigitated microelectrodes.