公开(公告)号：US20170209373A1

公开(公告)日：2017-07-27

申请号：US15361996

申请日：2016-11-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sehoon KIM ,  Youngsoo KIM ,  Youngsun KIM ,  Keunsoo JEONG ,  Ajay SINGH

IPC: A61K9/16 ,  A61K31/12 ,  A61K49/00 ,  A61K9/00

CPC classification number: A61K31/12 ,  A61K9/0019 ,  A61K9/5146 ,  A61K49/0021 ,  A61K49/0093

Abstract: The present invention relates to a drug delivery system (DDS) for crossing the blood-brain barrier (BBB) formed by self-assembly of an amphiphilic block copolymer, comprising a self-assembled structure having an average diameter of 5 nm to 20 nm of a core-shell structure comprising a hydrophobic core and a hydrophilic shell; and a hydrophobic drug supported in the hydrophobic core of the self-assembled structure, a pharmaceutical composition for preventing or treating cerebral diseases comprising the drug delivery system as an active ingredient, and a preparation method of the drug delivery system.

公开(公告)号：US20190041357A1

公开(公告)日：2019-02-07

申请号：US16077074

申请日：2016-11-09

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kyoseon HWANG ,  Jinsik KIM ,  Hye Jin KIM ,  Yong Kyoung YOO ,  Youngsoo KIM

IPC: G01N27/447 ,  B03C5/00 ,  G01N33/543

Abstract: The present disclosure relates to an interdigitated electrode biosensor using dielectrophoresis, including an insulating layer configured to fully cover a sensor forming region of a substrate, a first interdigitated microelectrode configured such that a plurality of first protruding electrodes is arranged in a shape of a comb on the substrate, a second interdigitated microelectrode configured such that a plurality of second protruding electrodes is arranged in a shape of a comb and each interdigitates with the plurality of first protruding electrodes formed in the first interdigitated microelectrode, and a plurality of receptors that is immobilized in a space between the first interdigitated microelectrode and the second interdigitated microelectrode and reacts specifically to target biomaterials, wherein different voltages are uniformly or nonuniformly applied to the first interdigitated microelectrode and the second interdigitated microelectrode to generate a dielectrophoretic force by a nonuniform electric field, and thus there are effects in improving the sensitivity and the detection width of the sensor by increasing the probability of specific reaction with the target biomaterials using the concentration effect through dielectrophoresis.