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    MICRO SENSING SYSTEM FOR DETECTING NEUROTROPHIC FACTORS
    3.
    发明申请
    MICRO SENSING SYSTEM FOR DETECTING NEUROTROPHIC FACTORS 审中-公开
    用于检测神经营养因子的微观传感系统

    公开(公告)号：US20150208963A1

    公开(公告)日：2015-07-30

    申请号：US14534378

    申请日：2014-11-06

    申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

    发明人： Hyunjoo Jenny LEE ,  Il-Joo CHO ,  Eui Sung YOON ,  Nakwon CHOI

    IPC分类号： A61B5/145 ,  A61B5/00

    CPC分类号： A61B5/14514 ,  A61B5/14503 ,  A61B5/4064 ,  A61B5/685

    摘要： A micro sensing system for real-time sensing a neurotrophic factor included in a body fluid includes a body, a neurotrophic factor channel formed in the body to allow a fluid flow therein, and a biosensor formed at the body to sense the neurotrophic factor, wherein the body fluid is extracted in a living body through the neurotrophic factor channel, and wherein the biosensor is disposed on a path of the neurotrophic factor channel to directly contact a body fluid flowing through the neurotrophic factor channel and senses a concentration of a neurotrophic factor in the body fluid.

    摘要翻译： 用于实时感测包括在体液中的神经营养因子的微观感测系统包括身体，在体内形成的允许流体流动的神经营养因子通道，以及形成在身体的生物传感器以感测神经营养因子，其中 体液通过神经营养因子通道在生物体中提取，其中生物传感器设置在神经营养因子通道的路径上，以直接接触流过神经营养因子通道的体液，并感测神经营养因子的浓度 体液。

    METHOD OF MANUFACTURING A NERVE ELECTRODE PROVIDED WITH ANTI-INFLAMMATORY DRUG
    5.
    发明申请
    METHOD OF MANUFACTURING A NERVE ELECTRODE PROVIDED WITH ANTI-INFLAMMATORY DRUG 审中-公开
    制造具有抗炎药物的神经电极的方法

    公开(公告)号：US20150265832A1

    公开(公告)日：2015-09-24

    申请号：US14733467

    申请日：2015-06-08

    申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

    发明人： Soo Hyun LEE ,  Ji Yoon KANG ,  Nakwon CHOI

    IPC分类号： A61N1/05

    CPC分类号： A61N1/0556 ,  A61B5/04001 ,  A61B2562/125 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/41 ,  A61L2300/43 ,  A61L2400/12 ,  A61L2420/08

    摘要： A method for manufacturing a nerve electrode that is inserted into a living body and that is configured to attach to nerves is provided. The nerve electrode includes: i) a flexible substrate; ii) a plurality of electrodes that are separately positioned on the flexible substrate; and iii) an insulating layer that is positioned at a separation space of the plurality of electrodes and that insulates the plurality of electrodes. The plurality of electrodes include i) at least one linear electrode, and ii) a planar electrode that is separated from the linear electrode. An anti-inflammatory drug transfer layer is positioned on the planar electrode.

    摘要翻译： 提供一种用于制造插入到生物体中并且被配置为附着到神经的神经电极的方法。 神经电极包括：i）柔性基底; ii）分别定位在柔性基板上的多个电极; 以及iii）绝缘层，其位于所述多个电极的分离空间处并使所述多个电极绝缘。 多个电极包括i）至少一个线状电极，以及ii）与线状电极分离的平面电极。 将抗炎药物转移层定位在平面电极上。

    HIGH RESOLUTION FLUORESCENCE IMAGING DEVICE AND METHOD FOR MANUFACTURING THE SAME
    6.
    发明申请
    HIGH RESOLUTION FLUORESCENCE IMAGING DEVICE AND METHOD FOR MANUFACTURING THE SAME 有权

    公开(公告)号：US20230110294A1

    公开(公告)日：2023-04-13

    申请号：US17962066

    申请日：2022-10-07

    申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

    发明人： Il-Joo CHO ,  Nakwon CHOI ,  Hyogeun SHIN

    IPC分类号： G01N15/14 ,  F21V8/00 ,  G02B1/04

    摘要： A high resolution fluorescence imaging device includes a light guide plate having a fluid channel which allows a solution containing a fluorescent sample to pass; a light source disposed on a side of the light guide plate to irradiate light inward the light guide plate; an image sensor disposed under the light guide plate;
    and a thin film interposed between the light guide plate and the image sensor, wherein the thin film has a first surface having a plurality of pillars and a second surface, the pillars separate the light guide plate and the image sensor apart from each other, and the second surface is bonded to the light guide plate. According to an embodiment, since the light guide plate acts in place of a filter element, it is possible to manufacture in ultrasmall size and achieve multiple fluorescence imaging without replacing a filter.

    STRETCHING APPARATUS AND METHOD FOR ALIGNING MICROFIBRILS
    7.
    发明申请
    STRETCHING APPARATUS AND METHOD FOR ALIGNING MICROFIBRILS 有权
    拉伸装置和微阵列的方法

    公开(公告)号：US20160152946A1

    公开(公告)日：2016-06-02

    申请号：US14950710

    申请日：2015-11-24

    申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

    发明人： Nakwon CHOI ,  Eun-Mi HUR ,  Sohyun KIM ,  Sun-Kyoung IM ,  Eui Sung YOON ,  Changjoon Justin LEE

    IPC分类号： C12N5/00

    CPC分类号： C12M35/04 ,  A61L27/165 ,  A61L27/3804 ,  A61L27/3826 ,  A61L27/383 ,  A61L27/3834 ,  A61L27/50 ,  A61L2430/32 ,  B29C55/02 ,  B29C55/023 ,  B29C55/12 ,  B29C55/20 ,  C08J5/00

    摘要： The present disclosure relates to stretching apparatus and method for aligning microfibrils. Specifically, the present disclosure provides an apparatus for aligning microfibrils along a single direction, which includes: a first elastic substrate onto which a composition containing microfibrils is loaded; and a stretching module which stretches the width of the elastic substrate. In accordance with the apparatus the present disclosure, microfibrils or cells may be aligned along a particular direction simply by pulling and then releasing the elastic substrate. The present disclosure is also useful for culturing of the aligned cells because the physiological activity of the cells can be maintained and cytotoxicity can be prevented.

    摘要翻译： 本发明涉及用于对准微纤丝的拉伸装置和方法。 具体地说，本公开内容提供了一种沿着单一方向对准微原纤维的装置，其包括：第一弹性基材，其上装载有微原纤维的组合物; 以及延伸弹性基板的宽度的拉伸模块。 根据本公开的装置，微原纤维或细胞可以简单地通过拉动然后释放弹性基底沿着特定方向排列。 本公开也可用于培养对准的细胞，因为可以保持细胞的生理活性并且可以防止细胞毒性。