公开(公告)号：US5958897A

公开(公告)日：1999-09-28

申请号：US4784

申请日：1998-01-09

申请人： Karla Jacobus ,  Janet Rideout ,  Ben Yerxa ,  William Pendergast ,  Suhaib Siddiqi ,  David Drutz

发明人： Karla Jacobus ,  Janet Rideout ,  Ben Yerxa ,  William Pendergast ,  Suhaib Siddiqi ,  David Drutz

IPC分类号： C07H19/067 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61P11/02 ,  A61P43/00 ,  C07H19/10 ,  C07H19/167 ,  C07H19/20 ,  A61K31/70

CPC分类号： A61K31/7048 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  C07H19/10 ,  C07H19/20

摘要： A method of promoting drainage of congested mucous secretions in the sinuses of a subject in need of such treatment is disclosed. The method comprises administering to the sinuses of the subject a uridine phosphate such as uridine 5'-triphosphate (UTP) or P.sup.1,P.sup.4 -di(uridine-5') tetraphosphate (U.sub.2 P.sub.4), an analog of UTP, or any other analog, in an amount effective to promote drainage of congested fluid in the sinuses by hydrating mucous secretions or by stimulating ciliary beat frequency in the sinuses. Pharmaceutical formulations and methods of making the same are also disclosed. Methods of administering the same would include any liquid suspension (including nasal drops or spray), oral form (liquid or pill), aerosol inhalation, powder form, topical, injected, intra-operative instillation or suppository form.

摘要翻译： 公开了一种促进需要这种治疗的受试者的窦内的拥挤的粘液分泌物的引流的方法。 该方法包括对受试者的鼻窦施用尿苷磷酸酯，例如尿苷5'-三磷酸（UTP）或P1，P4-二（尿苷-5'）四磷酸（U2P4），UTP的类似物或任何其它类似物， 通过保湿粘液分泌物或通过刺激窦内的睫状肌痉挛频率，有效促进窦内充血液引流。 还公开了药物制剂及其制备方法。 给药方法包括任何液体悬浮液（包括滴鼻剂或喷雾剂），口服形式（液体或药丸），气雾剂吸入剂，粉末形式，局部用药，注射剂，术中滴注或栓剂形式。

公开(公告)号：US5789391A

公开(公告)日：1998-08-04

申请号：US675620

申请日：1996-07-03

申请人： Karla Jacobus ,  Janet Rideout ,  Ben Yerxa ,  William Pendergast ,  Suhaib Siddiqi ,  David Drutz

发明人： Karla Jacobus ,  Janet Rideout ,  Ben Yerxa ,  William Pendergast ,  Suhaib Siddiqi ,  David Drutz

IPC分类号： C07H19/067 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61P11/02 ,  A61P43/00 ,  C07H19/10 ,  C07H19/167 ,  C07H19/20 ,  A61K31/70

CPC分类号： A61K31/7048 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  C07H19/10 ,  C07H19/20

摘要： A method of promoting drainage of congested mucous secretions in the sinuses of a subject in need of such treatment is disclosed. The method comprises administering to the sinuses of the subject a uridine phosphate such as uridine 5'-triphosphate (UTP) or P.sup.1,P.sup.4 -di(uridine-5') tetraphosphate (U.sub.2 P.sub.4), an analog of UTP, or any other analog, in an amount effective to promote drainage of congested fluid in the sinuses by hydrating mucous secretions or by stimulating ciliary beat frequency in the sinuses. Pharmaceutical formulations and methods of making the same are also disclosed. Methods of administering the same would include any liquid suspension (including nasal drops or spray), oral form (liquid or pill), aerosol inhalation, powder form, topical, injected, intra-operative instillation or suppository form.

公开(公告)号：US5981506A

公开(公告)日：1999-11-09

申请号：US4785

申请日：1998-01-09

申请人： Karla Jacobus ,  Janet Rideout ,  Ben Yerxa ,  William Pendergast ,  Suhaib Siddiqi ,  David Drutz

发明人： Karla Jacobus ,  Janet Rideout ,  Ben Yerxa ,  William Pendergast ,  Suhaib Siddiqi ,  David Drutz

IPC分类号： C07H19/067 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61P11/02 ,  A61P43/00 ,  C07H19/10 ,  C07H19/167 ,  C07H19/20 ,  A61K31/70

CPC分类号： A61K31/7048 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  C07H19/10 ,  C07H19/20

摘要： A method of promoting drainage of congested mucous secretions in the sinuses of a subject in need of such treatment is disclosed. The method comprises administering to the sinuses of the subject a uridine phosphate such as uridine 5'-triphosphate (UTP) or P.sup.1,P.sup.4 -di(uridine-5') tetraphosphate (U.sub.2 P.sub.4), an analog of UTP, or any other analog, in an amount effective to promote drainage of congested fluid in the sinuses by hydrating mucous secretions or by stimulating ciliary beat frequency in the sinuses. Pharmaceutical formulations and methods of making the same are also disclosed. Methods of administering the same would include any liquid suspension (including nasal drops or spray), oral form (liquid or pill), aerosol inhalation, powder form, topical, injected, intra-operative instillation or suppository form.

摘要翻译： 公开了一种促进需要这种治疗的受试者的窦内的拥挤的粘液分泌物的引流的方法。 该方法包括对受试者的鼻窦施用尿苷磷酸酯，例如尿苷5'-三磷酸（UTP）或P1，P4-二（尿苷-5'）四磷酸（U2P4），UTP的类似物或任何其它类似物， 通过保湿粘液分泌物或通过刺激窦内的睫状肌痉挛频率，有效促进窦内充血液引流。 还公开了药物制剂及其制备方法。 给药方法包括任何液体悬浮液（包括滴鼻剂或喷雾剂），口服形式（液体或药丸），气雾剂吸入剂，粉末形式，局部用药，注射剂，术中滴注或栓剂形式。

公开(公告)号：US5972904A

公开(公告)日：1999-10-26

申请号：US4786

申请日：1998-01-09

申请人： Karla Jacobus ,  Janet Rideout ,  Ben Yerxa ,  William Pendergast ,  Suhaib Siddiqi ,  David Drutz

发明人： Karla Jacobus ,  Janet Rideout ,  Ben Yerxa ,  William Pendergast ,  Suhaib Siddiqi ,  David Drutz

IPC分类号： C07H19/067 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61P11/02 ,  A61P43/00 ,  C07H19/10 ,  C07H19/167 ,  C07H19/20 ,  A61K31/70

CPC分类号： A61K31/7048 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  C07H19/10 ,  C07H19/20

摘要： A method of promoting drainage of congested mucous secretions in the sinuses of a subject in need of such treatment is disclosed. The method comprises administering to the sinuses of the subject a uridine phosphate such as uridine 5'-triphosphate (UTP) or P.sup.1,P.sup.4 -di(uridine-5') tetraphosphate (U.sub.2 P.sub.4), an analog of UTP, or any other analog, in an amount effective to promote drainage of congested fluid in the sinuses by hydrating mucous secretions or by stimulating ciliary beat frequency in the sinuses. Pharmaceutical formulations and methods of making the same are also disclosed. Methods of administering the same would include any liquid suspension (including nasal drops or spray), oral form (liquid or pill), aerosol inhalation, powder form, topical, injected, intra-operative instillation or suppository form.