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公开(公告)号：US07608692B2
公开(公告)日：2009-10-27
申请号：US12101689
申请日：2008-04-11
CPC分类号： C07K14/605 , A61K47/60
摘要： Modified exendins and exendin agonists having an exendin or exendin agonist linked to one or more polyethylene glycol polymers, for example, and related formulations and dosages and methods of administration thereof are provided. These modified exendins and exendin agonists, compositions and methods are useful in treating diabetes and conditions that would be benefited by lowering plasma glucose or delaying and/or slowing gastric emptying or inhibiting food intake.
摘要翻译： 提供了具有与一种或多种聚乙二醇聚合物连接的毒蜥外泌肽或毒蜥外泌激素的修饰的毒蜥外泌肽和毒蜥外泌肽激动剂，以及相关的制剂和剂量以及施用方法。 这些修饰的毒蜥外泌肽和毒蜥外泌肽激动剂，组合物和方法可用于治疗通过降低血浆葡萄糖或延迟和/或减缓胃排空或抑制食物摄取而受益的糖尿病和病症。
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公开(公告)号：US20120135922A1
公开(公告)日：2012-05-31
申请号：US13296120
申请日：2011-11-14
CPC分类号： C07K14/605 , A61K47/60
摘要： Novel modified exendins and exendin agonists having an exendin or exendin agonist linked to one or more polyethylene glycol polymers, for example, and related formulations and dosages and methods of administration thereof are provided. These modified exendins and exendin agonists, compositions and methods are useful in treating diabetes and conditions that would be benefited by lowering plasma glucose or delaying and/or slowing gastric emptying or inhibiting food intake.
摘要翻译： 提供了具有与一种或多种聚乙二醇聚合物连接的毒蜥外泌肽或毒蜥外泌激素的新型修饰的毒蜥外泌肽和毒蜥外泌肽激动剂，以及相关的制剂和剂量以及施用方法。 这些修饰的毒蜥外泌肽和毒蜥外泌肽激动剂，组合物和方法可用于治疗通过降低血浆葡萄糖或延迟和/或减缓胃排空或抑制食物摄取而受益的糖尿病和病症。
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3.发明授权公开(公告)号：US07683030B2
公开(公告)日：2010-03-23
申请号：US12046038
申请日：2008-03-11
CPC分类号： C07K14/605 , A61K47/60
摘要： Modified exendins and exendin agonists having an exendin or exendin agonist linked to one or more polyethylene glycol polymers, for example, and related formulations and dosages and methods of administration thereof are provided. These modified exendins and exendin agonists, compositions and methods are useful in treating diabetes and conditions that would be benefited by lowering plasma glucose or delaying and/or slowing gastric emptying or inhibiting food intake.
摘要翻译： 提供了具有与一种或多种聚乙二醇聚合物连接的毒蜥外泌肽或毒蜥外泌激素的修饰的毒蜥外泌肽和毒蜥外泌肽激动剂，以及相关的制剂和剂量以及施用方法。 这些修饰的毒蜥外泌肽和毒蜥外泌肽激动剂，组合物和方法可用于治疗通过降低血浆葡萄糖或延迟和/或减缓胃排空或抑制食物摄取而受益的糖尿病和病症。
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公开(公告)号：US06858576B1
公开(公告)日：2005-02-22
申请号：US08908867
申请日：1997-08-08
IPC分类号： A61K45/00 , A61K38/00 , A61K38/22 , A61P1/00 , A61P1/06 , C07K7/02 , C07K14/575 , A61K38/16 , A61K38/17 , A61K38/26 , C07K5/00
CPC分类号： C07K14/605 , A61K38/00 , A61K38/22 , A61K38/26 , C07K14/57563 , A61K2300/00
摘要： Methods for reducing gastric motility and delaying gastric emptying for therapeutic and diagnostic purposes are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist. Methods for treating conditions associated with elevated, inappropriate, or undesired post-prandial blood glucose levels are disclosed which comprise administration of an effective amount of an exendin or an exendin agonist alone or in conjunction with other anti-gastric emptying agents.
摘要翻译： 公开了减少胃动力和延迟胃排空用于治疗和诊断目的的方法，其包括施用有效量的毒蜥外泌肽或毒蜥外泌肽激动剂。 公开了治疗与升高的，不适当的或不期望的餐后血糖水平相关的病症的方法，其包括单独施用有效量的毒蜥外泌肽或毒蜥外泌肽激素，或与其他抗胃排空剂联合施用。
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公开(公告)号：US07928065B2
公开(公告)日：2011-04-19
申请号：US12247141
申请日：2008-10-07
IPC分类号： A61K38/22 , C07K14/575
CPC分类号： A61K38/26 , A61K31/00 , A61K38/2278 , Y10S514/866
摘要： Methods for increasing urine flow are disclosed, comprising administration of an effective amount of GLP-1, an exendin, or an exendin or GLP-1 agonist. Methods for increasing urinary sodium excretion and decreasing urinary potassium concentration are also disclosed. The methods are useful for treating conditions or disorders associated with toxic hypervolemia, such as renal failure, congestive heart failure, nephrotic syndrome, cirrhosis, pulmonary edema, and hypertension. The present invention also relates to methods for inducing an inotropic response comprising administration of an effective amount of GLP-1, an exendin, or an exendin or GLP-1 agonist. These methods are useful for treating conditions or disorders that can be alleviated by an increase in cardiac contractility such as congestive heart failure. Pharmaceutical compositions for use in the methods of the invention are also disclosed.
摘要翻译： 公开了增加尿流量的方法，包括施用有效量的GLP-1，毒蜥外泌肽或毒蜥外泌肽或GLP-1激动剂。 还公开了增加尿钠排泄量和降低尿钾浓度的方法。 该方法可用于治疗与毒性高血容量相关的病症或病症，例如肾衰竭，充血性心力衰竭，肾病综合征，肝硬化，肺水肿和高血压。 本发明还涉及诱导肌力反应的方法，包括施用有效量的GLP-1，毒蜥外泌肽或毒蜥外泌肽或GLP-1激动剂。 这些方法可用于治疗可通过增加心脏收缩力如充血性心力衰竭而减轻的病症或障碍。 还公开了用于本发明方法的药物组合物。
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公开(公告)号：US06924264B1
公开(公告)日：2005-08-02
申请号：US09561226
申请日：2000-04-28
CPC分类号： C07K14/605 , A61K47/60
摘要： Novel modified exendins and exendin agonist analogs having an exendin or exendin agonist analog linked to one or more polyethylene glycol polymers, for example, and related formulations and dosages and methods of administration thereof are provided. These modified exendins and exendin agonist analogs, compositions and methods are useful in treating diabetes and conditions that would be benefited by lowering plasma glucose or delaying and/or slowing gastric emptying or inhibiting food intake.
摘要翻译： 提供了具有与一种或多种聚乙二醇聚合物连接的毒蜥外泌肽或毒蜥外泌激素类似物的新型修饰的毒蜥外泌肽和毒蜥外泌激素类似物，以及相关的制剂和剂量及其施用方法。 这些修饰的毒蜥外泌肽和毒蜥外泌激素类似物，组合物和方法可用于治疗通过降低血浆葡萄糖或延迟和/或减缓胃排空或抑制食物摄取而受益的糖尿病和病症。
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公开(公告)号：US5739106A
公开(公告)日：1998-04-14
申请号：US477727
申请日：1995-06-07
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61K38/23 , A61K45/06 , A61P3/04 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/575 , C07K14/595 , A61K38/28 , C07K5/00 , C07K7/00
CPC分类号： C07K14/595 , A61K38/23 , C07K14/575 , A61K38/00 , C07K2319/00
摘要： Compositions and methods for reducing food intake, suppressing appetite and controlling body weight are provided. Such compositions may include an amylin agonist and a CCK agonist or a hybrid peptide.
摘要翻译： 提供了减少食物摄取，抑制食欲和控制体重的组合物和方法。 这样的组合物可以包括胰岛淀粉样多肽激动剂和CCK激动剂或杂交肽。
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公开(公告)号：US08445647B2
公开(公告)日：2013-05-21
申请号：US13296120
申请日：2011-11-14
CPC分类号： C07K14/605 , A61K47/60
摘要： Novel modified exendins and exendin agonists having an exendin or exendin agonist linked to one or more polyethylene glycol polymers, for example, and related formulations and dosages and methods of administration thereof are provided. These modified exendins and exendin agonists, compositions and methods are useful in treating diabetes and conditions that would be benefited by lowering plasma glucose or delaying and/or slowing gastric emptying or inhibiting food intake.
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公开(公告)号：US08057822B2
公开(公告)日：2011-11-15
申请号：US11174089
申请日：2005-06-30
CPC分类号： C07K14/605 , A61K47/60
摘要： Novel modified exendins and exendin agonists having an exendin or exendin agonist linked to one or more polyethylene glycol polymers, for example, and related formulations and dosages and methods of administration thereof are provided. These modified exendins and exendin agonists, compositions and methods are useful in treating diabetes and conditions that would be benefited by lowering plasma glucose or delaying and/or slowing gastric emptying or inhibiting food intake.
摘要翻译： 提供了具有与一种或多种聚乙二醇聚合物连接的毒蜥外泌肽或毒蜥外泌激素的新型修饰的毒蜥外泌肽和毒蜥外泌肽激动剂，以及相关的制剂和剂量以及施用方法。 这些修饰的毒蜥外泌肽和毒蜥外泌肽激动剂，组合物和方法可用于治疗通过降低血浆葡萄糖或延迟和/或减缓胃排空或抑制食物摄取而受益的糖尿病和病症。
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公开(公告)号：US07691963B2
公开(公告)日：2010-04-06
申请号：US12101818
申请日：2008-04-11
CPC分类号： C07K14/605 , A61K47/60
摘要： Modified exendins and exendin agonists having an exendin or exendin agonist linked to one or more molecular weight increasing compounds, for example, polyamino acids, polyethylene glycol polymers, and related formulations and dosages and methods of administration thereof are provided. These modified exendins and exendin agonists, compositions comprising the modified exendin or the agonist thereof are useful in treating diabetes and conditions that would be benefited by lowering plasma glucose or delaying and/or slowing gastric emptying or inhibiting food intake.
摘要翻译： 提供了具有连接至一种或多种分子量增加化合物的毒蜥外泌肽或毒蜥外泌激素的修饰的毒蜥外泌肽和毒蜥外泌肽激动剂，例如聚氨基酸，聚乙二醇聚合物，以及相关制剂及其给药方式及其施用方法。 这些修饰的毒蜥外泌肽和毒蜥外泌肽激动剂，包含修饰的毒蜥外泌肽或其激动剂的组合物可用于治疗糖尿病和通过降低血浆葡萄糖或延迟和/或减缓胃排空或抑制食物摄取而受益的病症。
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