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公开(公告)号：US5739106A
公开(公告)日：1998-04-14
申请号：US477727
申请日：1995-06-07
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61K38/23 , A61K45/06 , A61P3/04 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/575 , C07K14/595 , A61K38/28 , C07K5/00 , C07K7/00
CPC分类号： C07K14/595 , A61K38/23 , C07K14/575 , A61K38/00 , C07K2319/00
摘要： Compositions and methods for reducing food intake, suppressing appetite and controlling body weight are provided. Such compositions may include an amylin agonist and a CCK agonist or a hybrid peptide.
摘要翻译： 提供了减少食物摄取，抑制食欲和控制体重的组合物和方法。 这样的组合物可以包括胰岛淀粉样多肽激动剂和CCK激动剂或杂交肽。
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公开(公告)号：US5656590A
公开(公告)日：1997-08-12
申请号：US157003
申请日：1993-11-24
申请人： Timothy J. Rink , Andrew A. Young
发明人： Timothy J. Rink , Andrew A. Young
摘要： Method for treatment of a patient suffering from anorexia or a related condition by administering amylin or an analogue thereof and/or to the patient in an amount sufficient to increase amylin and/or insulin levels in the plasma of the patient.
摘要翻译： PCT No.PCT / US92 / 04357 Sec。 371日期：1993年11月24日 102（e）日期1993年11月24日PCT提交1992年5月23日PCT公布。 WO92 / 20367 PCT出版物 日期1992年11月26日通过以足以增加患者血浆中的胰岛淀粉样多肽和/或胰岛素水平的量施用胰岛淀粉样多肽或其类似物和/或给予患者来治疗患有厌食症或相关病症的患者的方法。
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公开(公告)号：US6114304A
公开(公告)日：2000-09-05
申请号：US302069
申请日：1994-09-07
IPC分类号： A61K45/00 , A61K35/39 , A61K38/22 , A61K38/23 , A61K49/00 , A61P1/00 , A61P1/14 , A61P3/10 , A61P25/02 , A61P43/00 , C07K14/585 , A61K37/02 , C07K7/10 , C07K7/36
CPC分类号： A61K38/23 , A61K38/22 , Y10S514/866
摘要： Methods for treating conditions associated with elevated, inappropriate or undesired post-prandial blood glucose levels are disclosed which comprise administration of an effective amount of an amylin agonist alone or in conjunction with other anti-gastric emptying agents. Methods for reducing gastric motility and delaying gastric emptying for therapeutic and diagnostic purposes are also described.
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公开(公告)号：US06608029B1
公开(公告)日：2003-08-19
申请号：US09576062
申请日：2000-05-22
IPC分类号： A61K3810
CPC分类号： A61K38/23 , A61K38/22 , Y10S514/866
摘要： Methods for treating conditions associated with elevated, inappropriate or undesired post-prandial blood glucose levels are disclosed which comprise administration of an effective amount of an amylin agonist alone or in conjunction with other anti-gastric emptying agents. Methods for reducing gastric motility and delaying gastric emptying for therapeutic and diagnostic purposes are also described.
摘要翻译： 公开了用于治疗与升高的，不适当的或不期望的餐后血糖水平相关的病症的方法，其包括单独施用有效量的胰岛淀粉样多肽激动剂或与其他抗胃排空剂联合施用。 还描述了用于减少胃动力和延迟胃排空用于治疗和诊断目的的方法。
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公开(公告)号：US6048514A
公开(公告)日：2000-04-11
申请号：US422747
申请日：1995-04-14
CPC分类号： A61K49/0008 , A61K49/0004 , G01N33/74 , G01N33/66 , Y10S514/866 , Y10S514/884
摘要： Novel methods for use in identifying or assaying compounds which can simulate the ability of amylin to cause hyperlactemia and hyperglycemia in in vivo biological models, or for use in evaluating the potency of compounds known or suspected to simulate these actions of amylin, which involve introducing test samples into in vivo test systems and determining the presence or amount of a rise in lactate, or determining the presence or amount of a rise in lactate and a rise in glucose, following test sample administration.
摘要翻译： 用于鉴定或测定化合物的新方法，其可以模拟胰岛淀粉样多肽在体内生物模型中引起高血糖和高血糖的能力，或用于评估已知或怀疑模拟胰岛淀粉样多肽的这些作用的化合物的效力，其涉及引入测试 样品进入体内测试系统并确定乳酸盐升高的存在或数量，或测定样品给药后确定乳酸盐升高的存在或量以及葡萄糖的升高。
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公开(公告)号：US07407934B2
公开(公告)日：2008-08-05
申请号：US10643681
申请日：2003-08-18
CPC分类号： A61K38/23 , A61K38/22 , Y10S514/866
摘要： Methods for treating conditions associated with elevated, inappropriate or undesired post-prandial blood glucose levels are disclosed which comprise administration of an effective amount of an amylin agonist alone or in conjunction with other anti-gastric emptying agents. Methods for reducing gastric motility and delaying gastric emptying for therapeutic and diagnostic purposes are also described.
摘要翻译： 公开了用于治疗与升高的，不适当的或不期望的餐后血糖水平相关的病症的方法，其包括单独施用有效量的胰岛淀粉样多肽激动剂或与其他抗胃排空剂联合施用。 还描述了用于减少胃动力和延迟胃排空用于治疗和诊断目的的方法。
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公开(公告)号：US5814600A
公开(公告)日：1998-09-29
申请号：US259762
申请日：1994-06-13
申请人： Timothy J. Rink , Andrew A. Young
发明人： Timothy J. Rink , Andrew A. Young
IPC分类号： A61K38/28
CPC分类号： A61K38/28
摘要： Method and compositions for treating a mammal by administering to that mammal an insulin (having the in vitro activity of stimulating glucose incorporation into glycogen in rat soleus muscle) and an amylin (having the in vitro activity of suppressing glucose incorporation into glycogen in rat soleus muscle) using specific molar ratios of an insulin to an amylin.
摘要翻译： 通过向哺乳动物施用胰岛素（具有刺激葡萄糖掺入大鼠比目鱼肌中的糖原的体外活性）和胰岛淀粉样多肽（具有抑制葡萄糖掺入大鼠比目鱼肌中糖原的体外活性）来治疗哺乳动物的方法和组合物 ）使用胰岛素与胰岛淀粉样多肽的特异摩尔比。
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8.发明授权
公开(公告)号：US5376638A
公开(公告)日：1994-12-27
申请号：US939106
申请日：1992-09-01
申请人： Andrew A. Young , Timothy J. Rink
发明人： Andrew A. Young , Timothy J. Rink
IPC分类号： A61K38/22 , A61K38/23 , A61K45/00 , A61P3/00 , A61P9/12 , A61P43/00 , G01N33/74 , A61K37/02 , C07K7/10
摘要： Methods for treating conditions associated with elevated, inappropriate or undesired renin activity are disclosed which comprise administration of an effective amount of any amylin antagonist alone or in conjunction with other anti-hypertensive agents. Methods for screening for and/or evaluating anti-renin amylin antagonists are also described.
摘要翻译： 公开了治疗与升高，不适当或不期望的肾素活性相关的病症的方法，其包括单独或与其它抗高血压药联合施用有效量的任何胰岛淀粉样多肽拮抗剂拮抗剂。 还描述了用于筛选和/或评估抗肾素胰岛淀粉样多肽的拮抗剂的方法。
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公开(公告)号：US5795861A
公开(公告)日：1998-08-18
申请号：US471675
申请日：1995-06-05
IPC分类号： A61K45/00 , A61K35/39 , A61K38/22 , A61K38/23 , A61K49/00 , A61P1/00 , A61P1/14 , A61P3/10 , A61P25/02 , A61P43/00 , C07K14/585 , A61K38/00 , C04K5/00 , C04K7/00
CPC分类号： A61K38/23 , A61K38/22 , Y10S514/866
摘要： Methods for treating conditions associated with elevated, inappropriate or undesired post-prandial blood glucose levels are disclosed which comprise administration of an effective amount of an amylin agonist alone or in conjunction with other anti-gastric emptying agents. Methods for reducing gastric motility and delaying gastric emptying for therapeutic and diagnostic purposes are also described.
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10.发明授权
公开(公告)号：US5264372A
公开(公告)日：1993-11-23
申请号：US670231
申请日：1991-03-15
申请人： Kevin Beaumont , Timothy J. Rink
发明人： Kevin Beaumont , Timothy J. Rink
IPC分类号： C07K14/575 , A61K38/28 , C07K14/00 , C07K14/585 , C07K14/705 , C07K16/00 , C07K19/00 , C12P21/08 , G01N20060101 , G01N33/53 , G01N33/566 , G01N33/567
CPC分类号： A61K38/28
摘要： Methods for identifying or screening or characterizing or assaying or isolating known or candidate agonists and antagonists of amylin, comprising binding assays utilizing preparations containing specific receptors for amylin. Membranes from the brain that contain high density receptors for amylin are particularly useful for the methods of this invention, and as a source of amylin receptors.
摘要翻译： 用于鉴定或筛选或表征或鉴定或分离胰岛淀粉样多肽的已知或候选激动剂和拮抗剂的方法，其包括使用含有胰岛淀粉样多肽特异性受体的制剂的结合测定。 包含胰岛淀粉样多肽的高密度受体的脑中的膜特别适用于本发明的方法和作为胰岛淀粉样多肽受体的来源。
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