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公开(公告)号：US20070053940A1
公开(公告)日：2007-03-08
申请号：US11556322
申请日：2006-11-03
申请人： Kelly Huang , Nikiforos Kollias , Ellen Kurtz , Katharine Martin , Florence Natter , Arthur Pellegrino
发明人： Kelly Huang , Nikiforos Kollias , Ellen Kurtz , Katharine Martin , Florence Natter , Arthur Pellegrino
IPC分类号： A61K8/02
CPC分类号： A61B5/442 , A61B5/0077 , G06T7/0012 , G06T2207/30004
摘要： The present invention includes a method of measuring the efficacy of a skin treatment program on human skin. The method comprises: a. accessing a multiplicity of photographic images of human faces, each image having associated with it a chronological age of the human whose likeness it captures; b. assessing the multiplicity of photographic images of human faces for a facial parameter; c. scoring the facial parameter on each image according to a scoring system to create a parameter score for each image; d. correlating the parameter scores to the chronological ages to obtain an age-parameter correlation; e. scoring an untreated subject human face for the facial parameter to obtain a subject baseline parameter score; f. treating the subject human face with a skin treatment program; g. scoring the treated subject human face for the facial parameter to obtain a subject treatment parameter score; h. determining the difference between the subject baseline parameter score and the subject treatment parameter score to obtain a treatment score difference; and i. comparing the treatment score difference with the age-parameter correlation to determine a constructive age change of the human face effected by treatment of the human face with the skin treatment program.
摘要翻译： 本发明包括测量皮肤处理程序对人体皮肤的功效的方法。 该方法包括：a。 访问人脸的多个摄影图像，每个图像与其相关联的是与其相似的人的时间年龄; b。 评估面部参数人脸摄影图像的多样性; C。 根据评分系统对每个图像上的面部参数进行评分，以创建每个图像的参数分数; d。 将参数分数与时间年龄相关联以获得年龄参数相关性; e。 为面部参数评分未经处理的受试者人脸以获得受试者基线参数得分; F。 用皮肤治疗方案治疗受试者的人脸; G。 对面部参数的受检对象人脸进行评分以获得受试者治疗参数得分; H。 确定受试者基准参数得分和受试者治疗参数得分之间的差异以获得治疗分数差; 和我。 将治疗分数差异与年龄参数相关性进行比较，以确定通过用皮肤治疗程序治疗人脸而实现的人脸的建构性年龄变化。
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2.发明申请Method of screening compounds for potential efficacy for the treatment of signs of aging 审中-公开筛选化合物治疗老化迹象的潜在疗效的方法公开(公告)号：US20060193777A1
公开(公告)日：2006-08-31
申请号：US11066361
申请日：2005-02-25
申请人： Michael Southall , Eduardo Ruvolo , Binoy Bordoloi , Katharine Martin , Nikiforos Kollias , Elvin Lukenbach , Gloria Lukenbach
发明人： Michael Southall , Eduardo Ruvolo , Binoy Bordoloi , Katharine Martin , Nikiforos Kollias , Elvin Lukenbach , Gloria Lukenbach
CPC分类号： G01N33/5044 , A61K49/0006 , G01N33/5026
摘要： The present invention features a method of screening a compound for potential efficacy for the treatment of at least one sign of aging on the skin selected from the group consisting of enhancing the elasticity of said skin, enhancing the firmness of said skin, or reducing the appearance of wrinkles on the skin, said method comprising contacting one or more skin cells with said compound and measuring the ability of said compound to contract said one or more skin cells.
摘要翻译： 本发明的特征在于一种筛选化合物的方法，用于治疗选自以下的至少一种皮肤老化迹象的潜在功效：选自增强所述皮肤的弹性，增强所述皮肤的硬度或减少外观 所述方法包括使一种或多种皮肤细胞与所述化合物接触并测量所述化合物收缩所述一种或多种皮肤细胞的能力。
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公开(公告)号：US20100262556A1
公开(公告)日：2010-10-14
申请号：US12820844
申请日：2010-06-22
申请人： Steven A. Shaya , Neal Matheson , John Anthony Singarayar , Nikiforos Kollias , Jeffrey Adam Bloom
发明人： Steven A. Shaya , Neal Matheson , John Anthony Singarayar , Nikiforos Kollias , Jeffrey Adam Bloom
CPC分类号： G06Q30/0631 , G06Q30/02 , G06Q30/0202 , G06Q30/0254 , G06Q30/0282 , G06Q30/0641
摘要： Systems and methods of utilizing communications networks and multivariate analysis to predict or recommend optimal products from a predefined population of commercially available products are disclosed. The recommendations are based on intelligence contained in processing elements and subjective and/or objective product information received from consumers or input to the systems as part of their initial setup. The output of the systems comprise sets of products that they predict the consumer will prefer and/or perform well for the problem or concern identified by the consumer. The performance and preference predictions are a function of consumer problems and product responsiveness patterns. Objective product information is generally obtained with diagnostic instruments. Data measured with the diagnostic instruments may be communicated to the data processing portions of the invention via the Internet. The outputs of the data processing portion of the system may be presented to consumers via the Internet as well.
摘要翻译： 公开了利用通信网络和多变量分析来预测或推荐来自预定义的市售产品群体的最佳产品的系统和方法。 这些建议是基于处理要素中包含的智能，以及从消费者收到的主观和/或客观的产品信息，或作为其初始设置的一部分输入到系统。 系统的输出包括他们预测消费者将更喜欢和/或对于消费者所识别的问题或关切而表现良好的产品集合。 性能和偏好预测是消费者问题和产品响应模式的函数。 客观的产品信息通常用诊断仪器获得。 用诊断仪器测量的数据可以经由因特网传送到本发明的数据处理部分。 系统的数据处理部分的输出也可以经由因特网向消费者呈现。
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公开(公告)号：US20100226861A1
公开(公告)日：2010-09-09
申请号：US12761461
申请日：2010-04-16
申请人： Curtis A. Cole , Nikiforos Kollias
发明人： Curtis A. Cole , Nikiforos Kollias
CPC分类号： A61Q17/04 , A61K8/02 , A61K2800/434 , A61K2800/438 , A61K2800/88 , G01N21/64
摘要： Compositions, devices, methods, and kits are provided for determining the presence of topical compositions on surfaces, such as skin.
摘要翻译： 提供组合物，装置，方法和试剂盒以确定表面如皮肤上局部组合物的存在。
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5.发明授权Imaging apparatus and methods for capturing and analyzing digital images of the skin 有权用于捕获和分析皮肤数字图像的成像设备和方法公开(公告)号：US07764303B2
公开(公告)日：2010-07-27
申请号：US11863342
申请日：2007-09-28
CPC分类号： H04N5/2354 , A61B5/0059 , A61B5/441 , G03B15/07 , H04N5/2252 , H04N9/045
摘要： An imaging station for taking a plurality of digital images of a subject under a plurality of illuminating conditions and storing and analyzing the digital images, includes a housing, containing the digital image capturing apparatus, like a camera or video recorder, a computer for processing the image data and one or more displays for displaying images of the person. The imaging station aids in controlling lighting during image capture and may be used to optimally position the subject for imaging. The computer may be programmed to conduct various image processing functions and may be networked to allow image sharing. A display which may be provided on the exterior of the housing allows an operator to visualize the subject and to control the imaging process. The imaging station may be used for teaching purposes.
摘要翻译： 一种用于在多个照明条件下拍摄对象的多个数字图像并存储和分析数字图像的成像站包括容纳数字图像捕获装置的外壳，如摄像机或录像机，用于处理 图像数据和用于显示人的图像的一个或多个显示器。 成像站有助于在图像捕获期间控制照明，并且可以用于最佳地定位被摄体以进行成像。 计算机可以被编程为执行各种图像处理功能，并且可以联网以允许图像共享。 可以设置在外壳的外部的显示器允许操作者可视化对象并控制成像处理。 成像站可用于教学目的。
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公开(公告)号：US20080080755A1
公开(公告)日：2008-04-03
申请号：US11863328
申请日：2007-09-28
申请人： Gregory Payonk , Nikiforos Kollias , Gabriela Cula
发明人： Gregory Payonk , Nikiforos Kollias , Gabriela Cula
IPC分类号： G06K11/00
CPC分类号： A61B5/0059 , A61B5/442 , G01J3/50
摘要： An apparatus and method for assessing photodamage has a digital imaging system for recording blue light imagining and in particular the green signal response intensity of the skin of a person, which is indicative of elastotic material and photodamage. Because the image data has a numerical intensity value, which may be expressed in RGB or L*a*b* colorspace, the image data taken from one image can be numerically compared to that of one or more other images and the image data is amenable to numerical and statistical analysis. Comparison to population profiles/image data permits an individual's image data to be characterized numerically, such as by a relative score or percentile rating. The image data can also be used to ascertain the degree of variation over a surface such as the face, with wider variation being indicative of greater photodamage.
摘要翻译： 用于评估光损伤的装置和方法具有用于记录蓝光想象的数字成像系统，特别是用于指示弹性材料和光损伤的人的皮肤的绿色信号响应强度。 由于图像数据具有可以以RGB或L * a * b *颜色空间表示的数值强度值，所以从一个图像获取的图像数据可以与一个或多个其他图像的图像数据进行数值比较，并且图像数据是可接受的 进行数值和统计分析。 与人口概况/图像数据的比较允许个人的图像数据以数字表示，例如通过相对评分或百分位数评级。 图像数据也可以用于确定诸如面部之类的表面上的变化程度，更广泛的变化指示更大的光损伤。
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7.发明申请Imaging Apparatus and Methods for Capturing and Analyzing Digital Images of the Skin 有权用于捕获和分析皮肤数字图像的成像装置和方法公开(公告)号：US20080079843A1
公开(公告)日：2008-04-03
申请号：US11863342
申请日：2007-09-28
CPC分类号： H04N5/2354 , A61B5/0059 , A61B5/441 , G03B15/07 , H04N5/2252 , H04N9/045
摘要： An imaging station for taking a plurality of digital images of a subject under a plurality of illuminating conditions and storing and analyzing the digital images, includes a housing, containing the digital image capturing apparatus, like a camera or video recorder, a computer for processing the image data and one or more displays for displaying images of the person. The imaging station aids in controlling lighting during image capture and may be used to optimally position the subject for imaging. The computer may be programmed to conduct various image processing functions and may be networked to allow image sharing. A display which may be provided on the exterior of the housing allows an operator to visualize the subject and to control the imaging process. The imaging station may be used for teaching purposes.
摘要翻译： 一种用于在多个照明条件下拍摄对象的多个数字图像并存储和分析数字图像的成像站包括容纳数字图像捕获装置的外壳，如摄像机或录像机，用于处理 图像数据和用于显示人的图像的一个或多个显示器。 成像站有助于在图像捕获期间控制照明，并且可以用于最佳地定位被摄体以进行成像。 计算机可以被编程为执行各种图像处理功能，并且可以联网以允许图像共享。 可以设置在外壳的外部的显示器允许操作者可视化对象并控制成像处理。 成像站可用于教学目的。
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公开(公告)号：US20070005393A1
公开(公告)日：2007-01-04
申请号：US11170297
申请日：2005-06-29
申请人： Curtis Cole , Nikiforos Kollias , Gregory Payonk
发明人： Curtis Cole , Nikiforos Kollias , Gregory Payonk
摘要： A system for conducting large scale clinical trials has a plurality of data collection nodes for collecting data from subjects participating in the clinical trial. A data analysis facility is located remotely from the data collection nodes and the data is communicated from the data collection nodes to the data analysis facility, where it is stored and analyzed. Each data collection node may include testing and data entry facilities, e.g., in the form of photographic equipment or various diagnostic and measuring probes, such as those used to measure skin color, elasticity and moisture content. The data nodes may be operated by the participant.
摘要翻译： 进行大规模临床试验的系统具有多个数据收集节点，用于收集参与临床试验的受试者的数据。 数据分析设备远离数据收集节点，数据从数据收集节点传送到数据分析设备，在那里进行存储和分析。 每个数据收集节点可以包括测试和数据输入设施，例如以照相设备或各种诊断和测量探针的形式，例如用于测量皮肤颜色，弹性和水分含量的那些。 数据节点可以由参与者操作。
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9.发明申请公开(公告)号：US20060268148A1
公开(公告)日：2006-11-30
申请号：US11497107
申请日：2006-08-01
IPC分类号： H04N5/225
CPC分类号： G03B29/00
摘要： The present invention relates to a method of photographing the skin of a person comprising: (i) illuminating the skin with at least one light source, wherein the light source emits substantially only light having a wavelength from about 380 to about 430 nm or emits light through a filter that emits substantially only light having a wavelength from about 380 to about 430 nm; and (ii) capturing the image of the illuminated skin with a camera; wherein the light entering the camera is also filtered with a long pass filter, wherein the long pass filter substantially eliminates light having a wavelength below about 400 nm.
摘要翻译： 本发明涉及拍摄人的皮肤的方法，包括：（i）用至少一个光源照射皮肤，其中光源基本上仅发射波长为约380至约430nm的光或发射光 通过基本上仅发射具有约380至约430nm的波长的光的滤光器; 和（ii）用相机拍摄照明皮肤的图像; 其中进入相机的光也用长通滤波器过滤，其中长通滤波器基本上消除波长低于约400nm的光。
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公开(公告)号：US5456260A
公开(公告)日：1995-10-10
申请号：US223428
申请日：1994-04-05
CPC分类号： A61B5/444 , A61B5/0071 , A61B5/445 , G01N21/6428
摘要： The method of the present invention is directed at detecting non-invasively and in vivo the rate of proliferation of epithelial cells in a human patient. The method is based on determining the optical spectra, preferably the fluorescence excitation spectra, from affected and non-affected areas of epithelial cells, and then comparing the two spectra from these regions. In particular, applicants have discovered that when human or animal skin is irradiated with light centered near 295 nm, fluorescence having a distinct maximum near 360 nm is induced.
摘要翻译： 本发明的方法涉及非侵入性和体内检测人类患者中上皮细胞增殖的速率。 该方法基于确定来自受影响和不受影响的上皮细胞区域的光谱，优选荧光激发光谱，然后比较来自这些区域的两个光谱。 特别地，申请人已经发现当人类或动物的皮肤被以295纳米为中心的光照射时，诱发具有不同于360nm附近的明显最大值的荧光。
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