公开(公告)号：US20240341579A1

公开(公告)日：2024-10-17

申请号：US18751215

申请日：2024-06-22

Applicant: KARL STORZ SE & CO. KG

Inventor： Werner GOEBEL ,  Henrik SPATH ,  Franz BAUER ,  Costantino PASCALE

IPC: A61B1/04 ,  A61B1/045 ,  A61B1/06 ,  A61B5/00 ,  G02B5/20 ,  H05B45/10

CPC classification number: A61B1/043 ,  A61B1/045 ,  A61B1/0646 ,  A61B1/0684 ,  A61B5/0071 ,  G02B5/205 ,  H05B45/10

Abstract: A light source configured for fluorescence diagnosis comprises a first semiconductor-illuminant based light emission unit configured to emit first light in a broadband first wavelength spectrum, a second semiconductor-illuminant based light emission unit configured to emit second light in a narrowband second wavelength spectrum for excitation of fluorescence, a spectral filter for the first light emission unit that is configured to block spectral components of the first wavelength spectrum which are assigned to a color channel of a camera the fluorescence is to be detected with, and to transmit remaining spectral components of the first wavelength spectrum, a brightness control for the first light emission unit configured to dim the intensity of the emitted first light, and an optical intensity attenuator for the first light emission unit that is configured to reduce the intensity of the emitted first light below the minimum intensity obtainable through the brightness control without the intensity attenuator.

公开(公告)号：US12114960B2

公开(公告)日：2024-10-15

申请号：US18298494

申请日：2023-04-11

Applicant: 3SHAPE A/S

Inventor： Mike Van Der Poel ,  Karl-Josef Hollenbeck

IPC: A61B5/00 ,  A61C9/00

CPC classification number: A61B5/0088 ,  A61B5/0071 ,  A61B5/742 ,  A61C9/0053 ,  A61B5/0035

Abstract: A 3D scanner system for detecting and/or visualizing cariogenic regions in teeth based on fluorescence emitted from the teeth, the 3D scanner system including one or more data processing units configured for mapping a representation of fluorescence emitted from the teeth onto the corresponding portion of a digital 3D representation of the teeth to provide a combined digital 3D representation.

公开(公告)号：US12076115B2

公开(公告)日：2024-09-03

申请号：US18133679

申请日：2023-04-12

Applicant: Alireza Moheb

Inventor： Alireza Moheb

IPC: A61B5/00 ,  G06T7/00

CPC classification number: A61B5/0088 ,  A61B5/0071 ,  A61B5/7264 ,  A61B5/7267 ,  A61B5/7275 ,  G06T7/0012 ,  A61B2576/02 ,  G06T2207/10012 ,  G06T2207/10024 ,  G06T2207/10116 ,  G06T2207/20084 ,  G06T2207/30036 ,  G06T2207/30096

Abstract: Systems for detecting and measuring certain dental defects and/or existing restorations, such as lesions which may or may not invade interproximal areas, using a neural network is disclosed. In some embodiments, a patient's health conditions and certain dental conditions such as crowding, presence of implants, gum disease, etc. are also considered by an automated system to classify the dental health of a patient into one or more risk classes. The system then suggests appropriate remedial measures and an appropriate maintenance program for that patient to keep therapy within guidelines of proven standard of care, leading the way to reduce tooth loss in population.

公开(公告)号：US20240285186A1

公开(公告)日：2024-08-29

申请号：US18560872

申请日：2022-05-16

Applicant: Stryker European Operations Limited

Inventor： Kevin Buckley ,  Gerard Nunan ,  Thomas Stritch

IPC: A61B5/06 ,  A61B5/00 ,  A61B5/1459

CPC classification number: A61B5/061 ,  A61B5/0071 ,  A61B5/1459

Abstract: An optical sensor system for detecting a tissue type in a surgical procedure is described. The optical sensor system includes an excitation source configured to selectively emit excitation light, a probe comprising at least one fiber coupled to the excitation source and configured to illuminate target tissue with excitation light and collect light from target tissue, a compliance member coupled to the at least one fiber, the compliance member being at least partially translucent and configured to deform in response to engagement by a surgical tool, an indicator element configured to emit light in response to receiving an indicator signal, an optical detection module coupled to the at least one fiber and configured to generate a signal based on the collected light, and a controller configured to determine a tissue characteristic based on the signal and generate the indicator signal based on the determined tissue characteristic.

公开(公告)号：US12067225B2

公开(公告)日：2024-08-20

申请号：US16401390

申请日：2019-05-02

Applicant: Canon USA, Inc.

Inventor： Christina Ho

IPC: G06F3/00 ,  A61B5/00 ,  G06F3/04845 ,  G06F3/04847 ,  G06F3/0485 ,  G06F3/04883 ,  G06F9/00 ,  G06F17/00

CPC classification number: G06F3/04847 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/7425 ,  A61B5/7435 ,  A61B5/748 ,  G06F3/04845 ,  G06F3/0485 ,  G06F3/04883 ,  G06F2203/04808

Abstract: One or more devices, systems, methods and storage mediums for optical imaging medical devices, such as, but not limited to, Optical Coherence Tomography (OCT), single mode OCT, and/or multi-modal OCT apparatuses and systems, and methods and storage mediums for use with same, for viewing, controlling, updating, and emphasizing multiple imaging modalities are provided herein. One or more embodiments provide at least one intuitive Graphical User Interface (GUI), method, device, apparatus, system, or storage medium to comprehend information, including, but not limited to, molecular structure of a vessel, and to provide an ability to manipulate the vessel information. In addition to controlling multiple imaging modalities, the GUI may operate for one or more applications, including, but not limited to, expansion/underexpansion (e.g., for a stent) and/or apposition/malapposition (e.g., for a stent), co-registration and imaging.

公开(公告)号：US20240260909A1

公开(公告)日：2024-08-08

申请号：US18614944

申请日：2024-03-25

Applicant: The Trustees of Dartmouth College

Inventor： Kenneth Tichauer ,  Robert W. Holt ,  Frederic Leblond ,  Pablo Valdes ,  Brian W. Pogue ,  Keith D. Paulsen ,  David W. Roberts

IPC: A61B5/00 ,  A61K49/00

CPC classification number: A61B5/7278 ,  A61B5/0071 ,  A61K49/0058 ,  A61B5/0035 ,  A61B5/0062 ,  A61B2576/00

Abstract: A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.

公开(公告)号：US12053262B2

公开(公告)日：2024-08-06

申请号：US17155141

申请日：2021-01-22

Applicant: Precision Healing, Inc.

Inventor： David B Strasfeld ,  Ira M Herman ,  W David Lee ,  Ryan Daniel Williams ,  Sean P Madden

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N1/40 ,  G01N21/64 ,  G16B40/00 ,  G16B45/00 ,  G16C20/70 ,  G16C20/80 ,  G16H10/40 ,  G16H20/10 ,  G16H20/30 ,  G16H30/40 ,  G16H50/20

CPC classification number: A61B5/0071 ,  A61B5/0075 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/443 ,  A61B5/444 ,  A61B5/445 ,  A61B5/4842 ,  A61B5/7282 ,  G01N1/405 ,  G01N21/6428 ,  G01N21/6456 ,  G16B40/00 ,  G16B45/00 ,  G16C20/70 ,  G16C20/80 ,  G16H10/40 ,  G16H20/10 ,  G16H20/30 ,  G16H30/40 ,  G16H50/20 ,  A61B5/4866 ,  A61B2562/0233 ,  A61B2576/02 ,  G01N2021/6439

Abstract: Disclosed techniques include skin diagnostics using optical signatures. A plurality of optical excitation light wavelength bands is scanned on a material sample, wherein the material sample exhibits optical spectral characteristics along the light wavelength spectrum. Excitation response wavelengths emitted by the material sample are captured in response to the plurality of optical excitation light wavelength bands, wherein the capturing is accomplished using an imaging sensor. Output values of a plurality of pixels of an image from the imaging sensor are measured, wherein the image represents excitation response wavelengths captured by the imaging sensor, wherein the measuring detects optical spectral characteristics of the material sample, and wherein the optical spectral characteristics are in response to the plurality of optical excitation light wavelength bands. An output signature indicative of composition of the material sample is generated, wherein the output signature is based on interpreting the output values that were measured.

公开(公告)号：US12048750B2

公开(公告)日：2024-07-30

申请号：US17888072

申请日：2022-08-15

Applicant: Blaze Bioscience, Inc.

Inventor： Stacey J. Hansen ,  Claudia Jochheim ,  Dennis M. Miller ,  Natalie Winblade Nairn ,  Julia E. Novak ,  Mark R. Stroud ,  Valorie R. Wiss ,  Kelly Byrnes-Blake ,  Scott Presnell

IPC: A61K38/00 ,  A61B5/00 ,  A61B6/00 ,  A61B6/03 ,  A61B6/40 ,  A61K47/64 ,  A61K47/65 ,  A61K49/00 ,  A61K51/08 ,  A61P13/12 ,  A61P19/02 ,  C07K14/435 ,  C07K14/47 ,  C07K16/24 ,  A61B5/055 ,  A61B8/08

CPC classification number: A61K47/6415 ,  A61B5/0071 ,  A61B6/037 ,  A61B6/4057 ,  A61B6/481 ,  A61K47/65 ,  A61K49/0056 ,  A61K49/0058 ,  A61K51/08 ,  A61P13/12 ,  A61P19/02 ,  C07K14/43518 ,  C07K14/43522 ,  C07K14/4726 ,  C07K16/244 ,  C07K16/248 ,  A61B5/055 ,  A61B8/481 ,  A61B2505/05 ,  C07K2319/30 ,  C07K2319/33 ,  C07K2319/50

Abstract: Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.

公开(公告)号：US20240247781A1

公开(公告)日：2024-07-25

申请号：US18598177

申请日：2024-03-07

Applicant: Panasonic Intellectual Property Management Co., Ltd.

Inventor： Mitsuru NITTA ,  Shozo OSHIO ,  Takeshi ABE

IPC: F21V9/30 ,  A61B1/04 ,  A61B1/06 ,  A61B5/00 ,  A61N5/06 ,  A61N5/067 ,  F21W131/20 ,  F21Y115/30

CPC classification number: F21V9/30 ,  A61B5/0071 ,  A61N5/062 ,  A61N5/067 ,  A61B1/043 ,  A61B1/0653 ,  F21W2131/20 ,  F21Y2115/30

Abstract: A light-emitting device includes: a light source that radiates primary light; and a first phosphor that absorbs the primary light and converts the primary light into first wavelength-converted light having a longer wavelength than the primary light, the first wavelength-converted light includes fluorescence based on electron energy transition of Cr3+, and a fluorescence spectrum of the first wavelength-converted light has a maximum fluorescence intensity value in region of a wavelength exceeding 710 nm.

公开(公告)号：US20240245346A1

公开(公告)日：2024-07-25

申请号：US18599306

申请日：2024-03-08

Applicant: Precision Healing, Inc.

Inventor： David B Strasfeld ,  Ryan Daniel Williams ,  Ira M Herman ,  W David Lee

IPC: A61B5/00 ,  A61B5/01

CPC classification number: A61B5/445 ,  A61B5/0071 ,  A61B5/015 ,  A61B5/443

Abstract: Disclosed techniques include image analysis using skin wound factors. One or more skin wound images are obtained for an individual. The skin wound images provide light spectrum information that includes fluorescence and reflectance characteristics. The light spectrum information includes infrared thermal characteristics. Processors are used to analyze the skin wound images to determine metrics for skin wound factors, based on the light spectrum information. The skin wound factors comprise infection, inflammation, granulation, topology, and epithelialization. An epithelialization metric is included in determining skin wound topology. The skin wound topology comprises wound area, wound volume, wound depth, wound shape, wound edge definition, or wound topography. An output indicative of biophysical skin wound status is generated. The output is based on the analyzing of the skin wound factors. The output is augmented, based on analysis of the infrared thermal characteristics. A skin wound care plan is developed, based on the output.