公开(公告)号：US3996263A

公开(公告)日：1976-12-07

申请号：US574376

申请日：1975-05-05

申请人： Kiyoshi Sakai ,  Takashi Yusa ,  Junya Ide ,  Mitsuo Yamazaki ,  Shinsaku Kobayashi

发明人： Kiyoshi Sakai ,  Takashi Yusa ,  Junya Ide ,  Mitsuo Yamazaki ,  Shinsaku Kobayashi

IPC分类号： C07C405/00 ,  C07D307/93 ,  C07D307/935 ,  C07D317/72 ,  C07C177/00

CPC分类号： C07D307/935 ,  C07C405/00 ,  C07D307/93 ,  C07D317/72

摘要： Prostanoic acid derivatives having the formula ##STR1## wherein A represents an alkylene group having from 4 to 8 carbon atoms, R.sup.1 represents an alkyl group having from one to 5 carbon atoms, R.sup.2 and R.sup.3 may be the same or different and each represents hydrogen atom or an alkyl group having from one to 4 carbon atoms and R.sup.4 represents hydrogen atom or an alkyl group having from one to 4 carbon atoms and the pharmaceutically acceptable salts thereof and also relates to a process for the preparation thereof.The compounds are useful as anti-ulcerogenic agents and may be prepared by reducing a compound having the formula ##STR2## wherein A, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same above and Z represents a carbonyl-protecting group to give a compound having the formula ##STR3## wherein A, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and Z are the same as above and removing the carbonyl-protecting group from the latter compound.

摘要翻译： 具有式的前列生酸衍生物，其中A表示具有4至8个碳原子的亚烷基，R 1表示具有1至5个碳原子的烷基，R 2和R 3可以相同或不同，各自表示氢原子 或具有1至4个碳原子的烷基和R 4表示氢原子或具有1至4个碳原子的烷基及其药学上可接受的盐，并且涉及其制备方法。

公开(公告)号：US4012429A

公开(公告)日：1977-03-15

申请号：US457564

申请日：1974-04-03

申请人： Kiyoshi Sakai ,  Osamu Oda ,  Takashi Yusa ,  Mitsuo Yamazaki ,  Masaaki Sasaki ,  Kazuhiko Sasagawa

发明人： Kiyoshi Sakai ,  Osamu Oda ,  Takashi Yusa ,  Mitsuo Yamazaki ,  Masaaki Sasaki ,  Kazuhiko Sasagawa

IPC分类号： C07D335/02 ,  A61K31/557 ,  A61K31/5575 ,  A61P43/00 ,  B01J31/00 ,  C07B61/00 ,  C07C43/174 ,  C07C51/00 ,  C07C59/74 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D307/93 ,  C07D307/935 ,  C07D309/12 ,  C07C177/00

CPC分类号： C07C43/174 ,  C07C405/00 ,  C07D307/93 ,  C07D309/12 ,  Y02P20/55

摘要： Prostanoic acid derivatives having the formula ##STR1## wherein A represents a straight or branched alkylene group having from one to 5 carbon atoms, R.sup.1 represents a straight or branched alkyl group having from 4 to 10 carbon atoms and R.sup.2 represents hydrogen atom or a straight or branched alkyl group having from one to 6 carbon atoms and pharmaceutically acceptable salts thereof.The compounds are useful as oxytocic agents and agents inhibiting the secretion of gastric acid and may be prepared by oxidizing a compound having the formula ##STR2## wherein A, R.sup.1 and R.sup.2 are the same as above, R.sup.3 and R.sup.4 are the same or different and each represents a protecting group for the hydroxyl group to give a compound having the formula ##STR3## wherein A, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same as above, removing the hydroxyl-protecting group from the latter compound and, if appropriate, salifying the product thus obtained.

摘要翻译： 具有式“IMAGE”的前列生酸衍生物，其中A表示具有1至5个碳原子的直链或支链亚烷基，R1表示具有4至10个碳原子的直链或支链烷基，R2表示氢原子或直链或支链 具有1至6个碳原子的支链烷基及其药学上可接受的盐。

公开(公告)号：US3971825A

公开(公告)日：1976-07-27

申请号：US527353

申请日：1974-11-26

申请人： Kiyoshi Sakai ,  Takashi Yusa ,  Kenji Inoue

发明人： Kiyoshi Sakai ,  Takashi Yusa ,  Kenji Inoue

IPC分类号： C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D307/935 ,  C07D309/12 ,  C07C61/38 ,  C07C69/74

CPC分类号： C07D307/935 ,  C07C405/00 ,  C07D309/12 ,  Y02P20/55

摘要： New prostaglandin-like compounds, having brochodilating activity, of formula ##SPC1##(wherein A represents a direct bond or an alkylene group and R.sup.1 represents an alkyl group) and their pharmaceutically acceptable salts are prepared by oxidizing compounds of formula ##SPC2##(wherein R.sup.2 represents hydrogen or a carboxyl-protecting group, and R.sup.3 represents a hydroxyl-protecting group), removing protecting groups from the product and, when appropriate, salifying the compound obtained.

摘要翻译： 具有通式（WHEREIN A代表直接键或亚烷基并且R 1表示烷基）的具有通菌活性的新的前列腺素样化合物及其药学上可接受的盐通过氧化式（WHEREIN R2表示氢或羧基） 保护基，R3表示羟基保护基），从产物中除去保护基，适当时将所得化合物进行成盐。

公开(公告)号：US3983152A

公开(公告)日：1976-09-28

申请号：US385868

申请日：1973-08-06

申请人： Osamu Oda ,  Kiyoshi Sakai ,  Takashi Yusa ,  Hamako Katano

发明人： Osamu Oda ,  Kiyoshi Sakai ,  Takashi Yusa ,  Hamako Katano

IPC分类号： A61K31/20 ,  B01J27/00 ,  B01J31/00 ,  C07B61/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D307/935 ,  C07D309/12 ,  C07D317/70 ,  C07D317/72 ,  C07D333/32 ,  C07D335/02 ,  C07C177/00

CPC分类号： C07D317/72 ,  C07C405/00 ,  Y02P20/55

摘要： Prostanoic acid derivatives having the formula ##SPC1##Wherein A represents an alkylene group having from 4 to 8 carbon atoms, R.sup.1 represents an alkyl group having from 4 to 10 carbon atoms, R.sup.2 represents hydrogen atom or an alkyl group having from one to 6 carbon atoms and R.sup.3 represents hydrogen atom or an alkoxycarbonyl group having from one to 6 carbon atoms in the alkyl moiety and the pharmaceutically acceptable salts thereof and also relates to a process for the preparation thereof.The compounds are useful as oxytocic agents and may be prepared by reducing the compound having the formula ##SPC2##Wherein A, R.sup.1, R.sup.2 and R.sup.3 are the same as above and Z represents a carbonyl-protecting group with a metal hydride complex in the presence or absence of an inert organic solvent to give a compound having the formula ##SPC3##Wherein A, R.sup.1, R.sup.2, R.sup.3 and Z are the same as above and removing the carbonyl-protecting group of the latter compound.

摘要翻译： 具有下式的前列腺酸衍生物，其中A表示具有4至8个碳原子的亚烷基，R 1表示具有4至10个碳原子的烷基，R 2表示氢原子或具有1至6个碳原子的烷基，R 3 表示氢原子或烷基部分中具有1至6个碳原子的烷氧基羰基及其药学上可接受的盐，并且涉及其制备方法。