公开(公告)号：US11771777B2

公开(公告)日：2023-10-03

申请号：US17085089

申请日：2020-10-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Dae-Ro Ahn ,  Thai Bao Dieu Hien

IPC: A61K47/56 ,  A61K47/69 ,  A61K31/7105 ,  A61P13/12 ,  C12N15/113

CPC classification number: A61K47/6931 ,  A61K31/7105 ,  A61K47/56 ,  A61P13/12 ,  C12N15/1135 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/351

Abstract: The present invention relates to three-dimensional self-assembled nucleic acid nanoparticles, a drug delivery system comprising the same, and a pharmaceutical composition for the prevention or treatment of acute kidney injury, which comprises the same. The three-dimensional self-assembled nucleic acid nanoparticles of the present invention, which have a tetrahedral structure, exhibit an excellent renal-targeting ability, and thus the nanoparticles conjugated with the pharmaceutically active ingredient for p53 exhibit excellent p53 and caspase 3 expression reductions in vitro and in vivo, and can thereby be applied to the prevention or treatment of acute kidney injury.

公开(公告)号：US09919001B2

公开(公告)日：2018-03-20

申请号：US14514855

申请日：2014-10-15

Applicant: Korea Institute of Science and Technology

Inventor： Dae-Ro Ahn

IPC: A61K47/48 ,  B82Y40/00 ,  C12N15/11 ,  A61K31/704 ,  A61K31/7088 ,  A61K9/51 ,  A61K38/00

CPC classification number: A61K31/704 ,  A61K9/5146 ,  A61K31/7088 ,  A61K38/00

Abstract: The present invention relates to a drug carrier having L-DNA nanocage structure prepared by using L-DNA, the mirror form of natural DNA, as a backbone. The drug carrier of the present invention has very superior cellular uptake efficiency and serum stability, so that it can be applied to deliver various drugs into cells usefully.